HAMAP logo

HAMAP rule MF_00131

Send feedback

General rule information [?]

Accession MF_00131
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name Trp_synth_alpha
Scope(s) Bacteria
Template(s) P0A877 (TRPA_ECOLI); P00929 (TRPA_SALTY); Q8U094 (TRPA_PYRFU); [ Recover all ]
Triggered by HAMAP; MF_00131 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRPA
Protein name RecName: Full=Tryptophan synthase alpha chain;
Gene name Name=trpA;

Comments [?]

FUNCTIONThe alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
CATALYTIC ACTIVITY Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan; Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=;
PATHWAYAmino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 5/5.
SUBUNITTetramer of two alpha and two beta chains.
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the TrpA family.

Keywords [?]

Gene Ontology [?]

GO:0004834; Molecular function:tryptophan synthase activity
GO:0000162; Biological process:tryptophan biosynthetic process
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF00290; Trp_syntA; 1;
NCBIfam TIGR00262; TrpA; 1;

Features [?]

From: TRPA_ECOLI (P0A877)
Key From To Description Tag Condition FTGroup
ACT_SITE 49 49 /note="Proton acceptor" E
ACT_SITE 60 60 /note="Proton acceptor" [DE]

Additional information [?]

Size range 239-293 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Highly divergent CHLTR; sequence not included in alignment

View rule in raw text format (no links)