HAMAP rule MF_00131
General rule information
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| Accession | MF_00131 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41) |
| Name | Trp_synth_alpha |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | P0A877 (TRPA_ECOLI); P00929 (TRPA_SALTY); Q8U094 (TRPA_PYRFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00131 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRPA |
| Protein name | RecName: Full=Tryptophan synthase alpha chain; EC=4.2.1.20; |
| Gene name | Name=trpA; |
Comments
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| FUNCTION | The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. |
| CATALYTIC ACTIVITY | Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan; Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=4.2.1.20; |
| PATHWAY | Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 5/5. |
| SUBUNIT | Tetramer of two alpha and two beta chains. |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the TrpA family. |
Keywords
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Gene Ontology
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| GO:0004834; Molecular function:tryptophan synthase activity | |
| GO:0000162; Biological process:tryptophan biosynthetic process | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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Features
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| From: TRPA_ECOLI (P0A877) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 49 | 49 | /note="Proton acceptor" | E | ||||||||
| ACT_SITE | 60 | 60 | /note="Proton acceptor" | [DE] | ||||||||
Additional information
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| Size range | 239-293 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Highly divergent CHLTR; sequence not included in alignment |