Annotation rule MF_00131
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General rule information [?]

Accession MF_00131
Dates 1-JUN-2001 (Created)
26-SEP-2014 (Last updated, Version 38)
Name Trp_synth_alpha
Scope Bacteria
Archaea
Plastid
Templates P0A877 (TRPA_ECOLI); P00929 (TRPA_SALTY); Q8U094 (TRPA_PYRFU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRPA
Protein name
RecName: Full=Tryptophan synthase alpha chain;
EC=4.2.1.20;
Gene name
trpA

Comments [?]

Function The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Catalytic activity L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O.
Pathway Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.
Subunit Tetramer of two alpha and two beta chains.
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the TrpA family.

Keywords [?]

Amino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
Lyase

Gene Ontology [?]

GO:0004834; Molecular function: tryptophan synthase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF00290; Trp_syntA; 1;
TIGRFAMs TIGR00262; TrpA; 1;
PROSITE PS00167; TRP_SYNTHASE_ALPHA; 1;

Features [?]

From: TRPA_ECOLI (P0A877)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     49     49       Proton acceptor     E  
ACT_SITE     60     60       Proton acceptor     [DE]  

Additional information [?]

Size range 239-293 amino acids
Related rules None
Fusion None
Comments Highly divergent CHLTR; sequence not included in alignment


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