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HAMAP rule MF_00133

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General rule information [?]

Accession MF_00133
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 44)
Name Trp_synth_beta
Scope(s) Bacteria
Template(s) P0A2K1 (TRPB_SALTY); P0A879 (TRPB_ECOLI); Q8U093 (TRPB1_PYRFU); [ Recover all ]
Triggered by HAMAP; MF_00133 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRPB
Protein name RecName: Full=Tryptophan synthase beta chain;
Gene name Name=trpB;

Comments [?]

FUNCTIONThe beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
CATALYTIC ACTIVITY Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan; Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 5/5.
SUBUNITTetramer of two alpha and two beta chains.
SIMILARITYBelongs to the TrpB family.

Keywords [?]

Gene Ontology [?]

GO:0004834; Molecular function:tryptophan synthase activity
GO:0000162; Biological process:tryptophan biosynthetic process

Cross-references [?]

Pfam PF00291; PALP; 1;
NCBIfam TIGR00263; TrpB; 1;

Features [?]

From: TRPB_ECOLI (P0A879)
Key From To Description Tag Condition FTGroup
MOD_RES 87 87 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 388-459 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Highly divergent CHLTR; sequence not included in alignment. Duplicated trpB seems of archaebacterial origin. Some archaea have only such form (AERPE), some have only the classical form (METJA) and some have both including two bacteria (AQUAE and THEMA).

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