HAMAP rule MF_00133

General rule information [?]

Accession	MF_00133
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 44)
Name	Trp_synth_beta
Scope(s)	Bacteria Archaea
Template(s)	P0A2K1 (TRPB_SALTY); P0A879 (TRPB_ECOLI); Q8U093 (TRPB1_PYRFU); [ Recover all ]
Triggered by	HAMAP; MF_00133 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TRPB
Protein name	RecName: Full=Tryptophan synthase beta chain; EC=4.2.1.20;
Gene name	Name=trpB;

Comments [?]

FUNCTION	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
CATALYTIC ACTIVITY	Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan; Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=4.2.1.20;
COFACTOR	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAY	Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 5/5.
SUBUNIT	Tetramer of two alpha and two beta chains.
SIMILARITY	Belongs to the TrpB family.

Keywords [?]

Gene Ontology [?]

GO:0004834; Molecular function:tryptophan synthase activity

GO:0000162; Biological process:tryptophan biosynthetic process

Cross-references [?]

Features [?]

From: TRPB_ECOLI (P0A879)

Key

From

Description

Tag

Condition

FTGroup

MOD_RES

/note="N6-(pyridoxal phosphate)lysine"

Additional information [?]

Size range	388-459 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	Highly divergent CHLTR; sequence not included in alignment. Duplicated trpB seems of archaebacterial origin. Some archaea have only such form (AERPE), some have only the classical form (METJA) and some have both including two bacteria (AQUAE and THEMA).