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HAMAP rule MF_00138

General rule information [?]

Accession	MF_00138
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 32)
Name	GARS
Scope(s)	Bacteria Archaea
Template(s)	P15640 (PUR2_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00138 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PUR2
Protein name	RecName: Full=Phosphoribosylamine--glycine ligase; EC=6.3.4.13; AltName: Full=GARS; AltName: Full=Glycinamide ribonucleotide synthetase; AltName: Full=Phosphoribosylglycinamide synthetase;
Gene name	Name=purD;

Comments [?]

CATALYTIC ACTIVITY	Reaction=5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate; Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58681, ChEBI:CHEBI:143788, ChEBI:CHEBI:456216; EC=6.3.4.13;
PATHWAY	Purine metabolism; IMP biosynthesis via de novo pathway; N(1)- (5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1- diphosphate: step 2/2.
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
SUBUNIT	Monomer.
end case
SIMILARITY	Belongs to the GARS family.

Keywords [?]

Gene Ontology [?]

GO:0004637; Molecular function:phosphoribosylamine-glycine ligase activity

GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Features [?]

Additional information [?]

Size range	400-444 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	ARCFU is divergent, it has an insertion not found in other purD