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Annotation rule MF_00138
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General rule information [?]

Accession MF_00138
Dates 1-JUN-2001 (Created)
23-MAR-2020 (Last updated, Version 31)
Name GARS
Scope
Bacteria
Archaea
Template P15640 (PUR2_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PUR2
Protein name
RecName: Full=Phosphoribosylamine--glycine ligase;
EC 6.3.4.13;
AltName: Full=GARS;
AltName: Full=Glycinamide ribonucleotide synthetase;
AltName: Full=Phosphoribosylglycinamide synthetase;
Gene name
purD

Comments [?]

Catalytic activity RHEA:17453: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
EC 6.3.4.13
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Subunit Monomer.
end case
Similarity Belongs to the GARS family.

Keywords [?]


Gene Ontology [?]

GO:0004637; Molecular function: phosphoribosylamine-glycine ligase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam PF01071; GARS_A; 1;
PF02843; GARS_C; 1;
PF02844; GARS_N; 1;
TIGRFAMs TIGR00877; PurD; 1;
PROSITE PS00184; GARS; 1;
PS50975; ATP_GRASP; 1; trigger=PRU00409;

Additional information [?]

Size range 400-444 amino acids
Related rules None
Fusion None
Comments ARCFU is divergent, it has an insertion not found in other purD