HAMAP rule MF_00138
General rule information
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| Accession | MF_00138 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | GARS |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P15640 (PUR2_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00138 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PUR2 |
| Protein name | RecName: Full=Phosphoribosylamine--glycine ligase; EC=6.3.4.13; AltName: Full=GARS; AltName: Full=Glycinamide ribonucleotide synthetase; AltName: Full=Phosphoribosylglycinamide synthetase; |
| Gene name | Name=purD; |
Comments
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| CATALYTIC ACTIVITY | Reaction=5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate; Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58681, ChEBI:CHEBI:143788, ChEBI:CHEBI:456216; EC=6.3.4.13; |
| PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; N(1)- (5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1- diphosphate: step 2/2. |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| SUBUNIT | Monomer. |
| end case | |
| SIMILARITY | Belongs to the GARS family. |
Keywords
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Gene Ontology
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| GO:0004637; Molecular function:phosphoribosylamine-glycine ligase activity |
| GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
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| Pfam | PF01071; GARS_A; 1; |
| Pfam | PF02843; GARS_C; 1; |
| Pfam | PF02844; GARS_N; 1; |
| NCBIfam | TIGR00877; PurD; 1; |
| PROSITE | PS00184; GARS; 1; |
| PROSITE | PS50975; ATP_GRASP; 1; |
Features
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Additional information
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| Size range | 400-444 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | ARCFU is divergent, it has an insertion not found in other purD |