HAMAP rule MF_00146
General rule information
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Accession | MF_00146 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 24) |
Name | dCTP_deaminase |
Scope | Bacteria
Archaea |
Templates | P28248 (DCD_ECOLI); Q57872 (DCDB_METJA); P9WP17 (DCDB_MYCTU); Q9KFV3 (DCDB_HALH5): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <FTTag:bifunc1> and <FTTag:bifunc2>
Identifier |
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Protein name |
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else
Identifier |
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Protein name |
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end case
Gene name |
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Comments
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case <FTTag:bifunc1> and <FTTag:bifunc2>
Function | Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. |
Catalytic activity | RHEA:19205: dCTP + 2 H2O = diphosphate + dUMP + NH4(+)
EC 3.5.4.30 |
Pathway | Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1. |
else
Function | Catalyzes the deamination of dCTP to dUTP. |
Catalytic activity | RHEA:22680: dCTP + H(+) + H2O = dUTP + NH4(+)
EC 3.5.4.13 |
Pathway | Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. |
end case
Subunit | Homotrimer. |
Similarity | Belongs to the dCTP deaminase family. |
Keywords
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Gene Ontology
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case <FTTag:bifunc1> and <FTTag:bifunc2>
GO:0033973; Molecular function: dCTP deaminase (dUMP-forming) activity.
GO:0006226; Biological process: dUMP biosynthetic process.
GO:0006226; Biological process: dUMP biosynthetic process.
else
GO:0008829; Molecular function: dCTP deaminase activity.
GO:0006229; Biological process: dUTP biosynthetic process.
GO:0006229; Biological process: dUTP biosynthetic process.
end case
Cross-references
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Features
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From: DCDB_MYCTU (P9WP17) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 101 | 106 | /ligand="dCTP" /ligand_id="ChEBI:CHEBI:61481 | [KR]-S-[ST]-x-[GA]-R | ||||||||
BINDING (Optional) | 127 | 129 | /ligand="dCTP" /ligand_id="ChEBI:CHEBI:61481 | [TV]-L-E | ||||||||
ACT_SITE | 129 | 129 | Proton donor/acceptor | E | ||||||||
BINDING (Optional) | 119 | 119 | /ligand="dCTP" /ligand_id="ChEBI:CHEBI:61481 | D | ||||||||
BINDING (Optional) | 148 | 148 | /ligand="dCTP" /ligand_id="ChEBI:CHEBI:61481 | bifunc1 | Q | |||||||
BINDING (Optional) | 162 | 162 | /ligand="dCTP" /ligand_id="ChEBI:CHEBI:61481 | Y | ||||||||
BINDING (Optional) | 170 | 170 | /ligand="dCTP" /ligand_id="ChEBI:CHEBI:61481 | K | ||||||||
BINDING (Optional) | 174 | 174 | /ligand="dCTP" /ligand_id="ChEBI:CHEBI:61481 | Q | ||||||||
SITE (Optional) | 116 | 117 | Important for bifunctional activity | bifunc2 | G-[FWY] |
Additional information
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Size range | 154-240 amino acids |
Related rules | MF_00635 (DUT) |
Fusion | None |
Comments | Known bifunctional enzymes contain a Gly in position 116 (M.tuberculosis numbering), a Phe/Trp in position 117 and a Gln in position 148 (see PubMed:15539408 and PubMed:18164314). |