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HAMAP rule MF_00147

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General rule information [?]

Accession MF_00147
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 45)
Name TIM
Scope(s) Bacteria
Template(s) P9WG43 (TPIS_MYCTU); P00943 (TPIS_GEOSE); P0A858 (TPIS_ECOLI); Q6GIL6 (TPIS_STAAR); P50921 (TPIS_MORMI); P56076 (TPIS_HELPY); P62003 (TPIS_PYRWO); Q58923 (TPIS_METJA); O74025 (TPIS_METBR); Q8NKN9 (TPIS_THETK); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00147_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_00147_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TPIS
Protein name RecName: Full=Triosephosphate isomerase;
AltName: Full=Triose-phosphate isomerase;
Gene name Name=tpiA;

Comments [?]

FUNCTIONInvolved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
CATALYTIC ACTIVITY Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate; Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=;
PATHWAYCarbohydrate biosynthesis; gluconeogenesis.
PATHWAYCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate from glycerone phosphate: step 1/1.
case <OC:Archaea>
SUBUNITHomotetramer; dimer of dimers.
end case
case not <OC:Archaea>
end case
SIMILARITYBelongs to the triosephosphate isomerase family.

Keywords [?]

Gene Ontology [?]

GO:0004807; Molecular function:triose-phosphate isomerase activity
GO:0006094; Biological process:gluconeogenesis
GO:0006096; Biological process:glycolytic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00121; TIM; 1;
NCBIfam TIGR00419; Tim; 1;
PROSITE PS00171; TIM_1; 1;

Features [?]

Key From To Description Tag Condition FTGroup
case <OC:Bacteria>
BINDING 10 12 /ligand="substrate" N-x-K
BINDING 239 240 /ligand="substrate" G-G
ACT_SITE 100 100 /note="Electrophile" H
ACT_SITE 172 172 /note="Proton acceptor" E
BINDING 178 178 /ligand="substrate" G
BINDING 218 218 /ligand="substrate" S
end case
From: TPIS_BACSU (P27876)
Key From To Description Tag Condition FTGroup
case <OC:Bacillaceae>
MOD_RES 213 213 /note="Phosphoserine" S
end case
From: TPIS_PYRWO (P62003)
Key From To Description Tag Condition FTGroup
case <OC:Archaea>
BINDING 12 14 /ligand="substrate" N-x-K
BINDING 205 206 /ligand="substrate" A-S
ACT_SITE 96 96 /note="Electrophile" H
ACT_SITE 144 144 /note="Proton acceptor" E
BINDING 149 149 /ligand="substrate" I
BINDING 184 184 /ligand="substrate" G
end case

Additional information [?]

Size range 213-231 amino acids
Related rules None
Fusion Nter: MF_00145 (pgk) Cter: None
Comments Probable wrong start in CHLTR

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