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Annotation rule MF_00147 |
Accession | MF_00147 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 42) |
Name | TIM |
Scope | Bacteria
Archaea |
Templates | P9WG43 (TPIS_MYCTU); P00943 (TPIS_GEOSE); P0A858 (TPIS_ECOLI); Q6GIL6 (TPIS_STAAR); P50921 (TPIS_MORMI); P56076 (TPIS_HELPY); P62003 (TPIS_PYRWO); Q58923 (TPIS_METJA); O74025 (TPIS_METBR); Q8NKN9 (TPIS_THETK): [Recover all] |
Triggered by |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). |
Catalytic activity | RHEA:18585: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
EC 5.3.1.1 |
Pathway | Carbohydrate biosynthesis; gluconeogenesis. |
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. |
Subunit | Homotetramer; dimer of dimers. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the triosephosphate isomerase family. |
From: TPIS_MYCTU (P9WG43) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 10 | 12 | Substrate binding | N-x-K | ||||||||
REGION | 239 | 240 | Substrate binding | G-G | ||||||||
ACT_SITE | 100 | 100 | Electrophile | H | ||||||||
ACT_SITE | 172 | 172 | Proton acceptor | E | ||||||||
BINDING | 178 | 178 | Substrate; via amide nitrogen | G | ||||||||
BINDING | 218 | 218 | Substrate | S |
From: TPIS_BACSU (P27876) | ||||||||||||
MOD_RES | 213 | 213 | Phosphoserine | S |
From: TPIS_PYRWO (P62003) | ||||||||||||
REGION | 12 | 14 | Substrate binding | N-x-K | ||||||||
REGION | 205 | 206 | Substrate binding | A-S | ||||||||
ACT_SITE | 96 | 96 | Electrophile | H | ||||||||
ACT_SITE | 144 | 144 | Proton acceptor | E | ||||||||
BINDING | 149 | 149 | Substrate; via carbonyl oxygen | I | ||||||||
BINDING | 184 | 184 | Substrate; via amide nitrogen | G |
Size range | 223-293 amino acids |
Size range | 213-231 amino acids |
Related rules | None |
Fusion | Nter: MF_00145 (pgk); Cter: None |
Comments | Probable wrong start in CHLTR |