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Annotation rule MF_00147
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General rule information [?]

Accession MF_00147
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 42)
Name TIM
Scope
Bacteria
Archaea
Templates P9WG43 (TPIS_MYCTU); P00943 (TPIS_GEOSE); P0A858 (TPIS_ECOLI); Q6GIL6 (TPIS_STAAR); P50921 (TPIS_MORMI); P56076 (TPIS_HELPY); P62003 (TPIS_PYRWO); Q58923 (TPIS_METJA); O74025 (TPIS_METBR); Q8NKN9 (TPIS_THETK): [Recover all]
case <OC:Bacteria>
Triggered by
end case

case <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TPIS
Protein name
RecName: Full=Triosephosphate isomerase;
Short=TIM;
Short=TPI;
EC 5.3.1.1;
AltName: Full=Triose-phosphate isomerase;
Gene name
tpiA

Comments [?]

Function Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Catalytic activity RHEA:18585: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
EC 5.3.1.1
Pathway Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
case <OC:Archaea>
Subunit Homotetramer; dimer of dimers.
end case
case not <OC:Archaea>
Subunit Homodimer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the triosephosphate isomerase family.

Keywords [?]

Cytoplasm
Isomerase
Glycolysis
Gluconeogenesis
case <FT:7>
Phosphoprotein
end case

Gene Ontology [?]

GO:0004807; Molecular function: triose-phosphate isomerase activity.
GO:0006094; Biological process: gluconeogenesis.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00121; TIM; 1;
TIGRFAMs TIGR00419; Tim; 1;
PROSITE PS00171; TIM_1; 1;

Features [?]

case <OC:Bacteria>
From: TPIS_MYCTU (P9WG43)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     10     12       Substrate binding     N-x-K  
REGION     239     240       Substrate binding     G-G  
ACT_SITE     100     100       Electrophile     H  
ACT_SITE     172     172       Proton acceptor     E  
BINDING     178     178       Substrate; via amide nitrogen     G  
BINDING     218     218       Substrate     S  
end case
case <OC:Bacillaceae>
From: TPIS_BACSU (P27876)
MOD_RES     213     213       Phosphoserine     S  
end case
case <OC:Archaea>
From: TPIS_PYRWO (P62003)
REGION     12     14       Substrate binding     N-x-K  
REGION     205     206       Substrate binding     A-S  
ACT_SITE     96     96       Electrophile     H  
ACT_SITE     144     144       Proton acceptor     E  
BINDING     149     149       Substrate; via carbonyl oxygen     I  
BINDING     184     184       Substrate; via amide nitrogen     G  
end case

Additional information [?]

case <OC:Bacteria>
Size range 223-293 amino acids
end case
case <OC:Archaea>
Size range 213-231 amino acids
end case
Related rules None
Fusion Nter: MF_00145 (pgk); Cter: None
Comments Probable wrong start in CHLTR


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