HAMAP rule MF_00158

General rule information [?]

Accession	MF_00158
Dates	1-JUN-2001 (Created) 17-FEB-2023 (Last updated, Version 33)

Name

PanC

Scope

Bacteria; except Cyanobacteriota

Templates

P31663 (PANC_ECOLI); P9WIL5 (PANC_MYCTU); Q9X713 (PANC_CORGL): [Recover all]

Triggered by

HAMAP; MF_00158 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PANC

Protein name

RecName:		Full=Pantothenate synthetase;
		Short=PS;
		EC 6.3.2.1;
AltName:		Full=Pantoate--beta-alanine ligase;
AltName:		Full=Pantoate-activating enzyme;

Gene name

panC

Comments [?]

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalytic activity	RHEA:10912: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) EC 6.3.2.1
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism.
Similarity	Belongs to the pantothenate synthetase family.

Keywords [?]

ATP-binding
Cytoplasm
Ligase
Nucleotide-binding
Pantothenate biosynthesis

Gene Ontology [?]

GO:0004592; Molecular function: pantoate-beta-alanine ligase activity.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02569; Pantoate_ligase; 1;
TIGRFAMs	TIGR00018; PanC; 1;

Features [?]

From: PANC_MYCTU (P9WIL5)

Key From To Description Tag Condition FTGroup

BINDING 40 47 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 M-x(3)-H-x(2)-H

BINDING 158 161 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-x(2)-D

BINDING 195 198 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 x(3)-R

ACT_SITE 47 47 Proton donor H

BINDING 72 72 /ligand="beta-alanine" /ligand_id="ChEBI:CHEBI:57966 Q

BINDING 72 72 /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980 Q

BINDING 164 164 /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980 Q

BINDING (Optional) 187 187 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [VLIGA]

Additional information [?]

Size range	251-337 amino acids
Related rules	MF_01349 (PANCY supersedes the current rule)
Fusion	None
Comments	In Cyanobacteriota this protein is fused C-terminally to cytidylate kinase (see Bifunctional pantoate ligase/cytidylate kinase MF_01349). Possible sequence error in STRCO; weird insertion; not shown in alignment.

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