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HAMAP rule MF_00158

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General rule information [?]

Accession MF_00158
Dates 1-JUN-2001 (Created)
17-FEB-2023 (Last updated, Version 33)
Name PanC
Bacteria; except Cyanobacteriota
Templates P31663 (PANC_ECOLI); P9WIL5 (PANC_MYCTU); Q9X713 (PANC_CORGL): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Pantothenate synthetase;
AltName: Full=Pantoate--beta-alanine ligase;
AltName: Full=Pantoate-activating enzyme;
Gene name

Comments [?]

Function Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalytic activity RHEA:10912: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)
Pathway Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Subunit Homodimer.
Subcellular location Cytoplasm.
Miscellaneous The reaction proceeds by a bi uni uni bi ping pong mechanism.
Similarity Belongs to the pantothenate synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0004592; Molecular function: pantoate-beta-alanine ligase activity.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02569; Pantoate_ligase; 1;
TIGRFAMs TIGR00018; PanC; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     40     47       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     M-x(3)-H-x(2)-H  
BINDING     158     161       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x(2)-D  
BINDING     195     198       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     x(3)-R  
ACT_SITE     47     47       Proton donor     H  
BINDING     72     72       /ligand="beta-alanine" /ligand_id="ChEBI:CHEBI:57966     Q  
BINDING     72     72       /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980     Q  
BINDING     164     164       /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980     Q  
BINDING (Optional)     187     187       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [VLIGA]  

Additional information [?]

Size range 251-337 amino acids
Related rules MF_01349 (PANCY supersedes the current rule)
Fusion None
Comments In Cyanobacteriota this protein is fused C-terminally to cytidylate kinase (see Bifunctional pantoate ligase/cytidylate kinase MF_01349). Possible sequence error in STRCO; weird insertion; not shown in alignment.