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Annotation rule MF_00158 |
Accession | MF_00158 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 30) |
Name | PanC |
Scope | Bacteria; except Cyanobacteria
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Templates | P31663 (PANC_ECOLI); P9WIL5 (PANC_MYCTU); Q9X713 (PANC_CORGL): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. |
Catalytic activity | RHEA:10912: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)
EC 6.3.2.1 |
Pathway | Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Miscellaneous | The reaction proceeds by a bi uni uni bi ping pong mechanism. |
Similarity | Belongs to the pantothenate synthetase family. |
From: PANC_MYCTU (P9WIL5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 40 | 47 | ATP | M-x(3)-H-x(2)-H | ||||||||
NP_BIND | 158 | 161 | ATP | G-x(2)-D | ||||||||
NP_BIND | 195 | 198 | ATP | x(3)-R | ||||||||
ACT_SITE | 47 | 47 | Proton donor | H | ||||||||
BINDING | 72 | 72 | Beta-alanine | Q | ||||||||
BINDING | 72 | 72 | Pantoate | Q | ||||||||
BINDING | 164 | 164 | Pantoate | Q | ||||||||
BINDING (Optional) | 187 | 187 | ATP; via amide nitrogen and carbonyl oxygen | [VLIGA] |
Size range | 251-337 amino acids |
Related rules | MF_01349 (PANCY supersedes the current rule) |
Fusion | None |
Comments | In Cyanobacteria this protein is fused C-terminally to cytidylate kinase (see Bifunctional pantoate ligase/cytidylate kinase MF_01349). Possible sequence error in STRCO; weird insertion; not shown in alignment. |