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HAMAP rule MF_00158

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General rule information [?]

Accession MF_00158
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 35)
Name PanC
Scope(s) Bacteria
Template(s) P31663 (PANC_ECOLI); P9WIL5 (PANC_MYCTU); Q9X713 (PANC_CORGL); [ Recover all ]
Triggered by HAMAP; MF_00158 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PANC
Protein name RecName: Full=Pantothenate synthetase;
AltName: Full=Pantoate--beta-alanine ligase;
AltName: Full=Pantoate-activating enzyme;
Gene name Name=panC;

Comments [?]

FUNCTIONCatalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
CATALYTIC ACTIVITY Reaction=(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10912, ChEBI:CHEBI:15378, ChEBI:CHEBI:15980, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:456215; EC=;
PATHWAYCofactor biosynthesis; (R)-pantothenate biosynthesis; (R)- pantothenate from (R)-pantoate and beta-alanine: step 1/1.
MISCELLANEOUSThe reaction proceeds by a bi uni uni bi ping pong mechanism.
SIMILARITYBelongs to the pantothenate synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0004592; Molecular function:pantoate-beta-alanine ligase activity
GO:0015940; Biological process:pantothenate biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02569; Pantoate_ligase; 1;
NCBIfam TIGR00018; PanC; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 40 47 /ligand="ATP"
BINDING 158 161 /ligand="ATP"
BINDING 195 198 /ligand="ATP"
ACT_SITE 47 47 /note="Proton donor" H
BINDING 72 72 /ligand="beta-alanine"
BINDING 72 72 /ligand="(R)-pantoate"
BINDING 164 164 /ligand="(R)-pantoate"
BINDING 187 187 /ligand="ATP"

Additional information [?]

Size range 251-337 amino acids
Related rules MF_01349
Fusion Nter: None Cter: None
Comments In Cyanobacteriota this protein is fused C-terminally to cytidylate kinase (see Bifunctional pantoate ligase/cytidylate kinase MF_01349). Possible sequence error in STRCO; weird insertion; not shown in alignment.

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