HAMAP rule MF_00158
General rule information
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Accession | MF_00158 |
Dates | 1-JUN-2001 (Created) 17-FEB-2023 (Last updated, Version 33) |
Name | PanC |
Scope | Bacteria; except Cyanobacteriota
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Templates | P31663 (PANC_ECOLI); P9WIL5 (PANC_MYCTU); Q9X713 (PANC_CORGL): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. |
Catalytic activity | RHEA:10912: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)
EC 6.3.2.1 |
Pathway | Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Miscellaneous | The reaction proceeds by a bi uni uni bi ping pong mechanism. |
Similarity | Belongs to the pantothenate synthetase family. |
Keywords
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Gene Ontology
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GO:0004592; Molecular function: pantoate-beta-alanine ligase activity.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: PANC_MYCTU (P9WIL5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 40 | 47 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | M-x(3)-H-x(2)-H | ||||||||
BINDING | 158 | 161 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x(2)-D | ||||||||
BINDING | 195 | 198 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | x(3)-R | ||||||||
ACT_SITE | 47 | 47 | Proton donor | H | ||||||||
BINDING | 72 | 72 | /ligand="beta-alanine" /ligand_id="ChEBI:CHEBI:57966 | Q | ||||||||
BINDING | 72 | 72 | /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980 | Q | ||||||||
BINDING | 164 | 164 | /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980 | Q | ||||||||
BINDING (Optional) | 187 | 187 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [VLIGA] |
Additional information
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Size range | 251-337 amino acids |
Related rules | MF_01349 (PANCY supersedes the current rule) |
Fusion | None |
Comments | In Cyanobacteriota this protein is fused C-terminally to cytidylate kinase (see Bifunctional pantoate ligase/cytidylate kinase MF_01349). Possible sequence error in STRCO; weird insertion; not shown in alignment. |