HAMAP rule MF_00160
General rule information
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Accession | MF_00160 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 45) |
Name | SerC_aminotrans_5 |
Scope | Bacteria
Archaea |
Templates | P23721 (SERC_ECOLI); Q59196 (SERC_NIACI); P52878 (SERC_METBF); Q9RME2 (SERC_ALKAL); P80862 (SERC_BACSU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. |
Catalytic activity | RHEA:14329: 2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate
EC 2.6.1.52 |
RHEA:16573: 2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
EC 2.6.1.52 |
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Cofactor | pyridoxal 5'-phosphate Note: Binds 1 pyridoxal phosphate per subunit. |
Pathway | Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. |
case not <OC:Bacillota>
Pathway | Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. |
end case
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. |
Keywords
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case not <OC:Bacillota>
end case
Gene Ontology
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GO:0004648; Molecular function: O-phospho-L-serine:2-oxoglutarate aminotransferase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006564; Biological process: L-serine biosynthetic process.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006564; Biological process: L-serine biosynthetic process.
case not <OC:Bacillota>
GO:0008615; Biological process: pyridoxine biosynthetic process.
end case
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00266; Aminotran_5; 1; |
NCBIfam | TIGR01364; SerC_1; 1; |
PROSITE | PS00595; AA_TRANSFER_CLASS_5; 1; |
Features
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From: SERC_ECOLI (P23721) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 76 | 77 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | [GA]-[RST] | ||||||||
BINDING (Optional) | 239 | 240 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | N-T | ||||||||
BINDING (Optional) | 9 | 9 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 | S | ||||||||
BINDING (Optional) | 42 | 42 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 | R | ||||||||
BINDING | 102 | 102 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | [WF] | ||||||||
BINDING | 153 | 153 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | T | ||||||||
BINDING (Optional) | 174 | 174 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | D | ||||||||
BINDING | 197 | 197 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | Q | ||||||||
MOD_RES | 198 | 198 | N6-(pyridoxal phosphate)lysine | K |
Additional information
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Size range | 355-378 amino acids |
Related rules | None |
Fusion | None |
Comments | SerC is not involved in pyridoxine biosynthesis in B.subtilis, and probably also in other Bacillota. In these organisms, pyridoxal phosphate biosynthesis is achieved by an alternative pathway involving pdxS(yaaD) and pdxT(yaaE). SerC from Mycobacterium species are slightly divergent and could have a different activity. |