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Annotation rule MF_00160 |
General rule information
[?]
Accession |
MF_00160 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 40) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Phosphoserine aminotransferase;
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EC 2.6.1.52;
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AltName:
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Full=Phosphohydroxythreonine aminotransferase;
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Short=PSAT;
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Function |
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. |
Catalytic activity |
RHEA:14329: 2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate
EC 2.6.1.52
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RHEA:16573: 2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
EC 2.6.1.52
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Cofactor |
pyridoxal 5'-phosphate Note: Binds 1 pyridoxal phosphate per subunit. |
Pathway |
Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. |
case not <OC:Firmicutes>
Pathway |
Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. |
end case
Subunit |
Homodimer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. |
case not <OC:Firmicutes>
end case
GO:0004648; Molecular function: O-phospho-L-serine:2-oxoglutarate aminotransferase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006564; Biological process: L-serine biosynthetic process.
case not <OC:Firmicutes>
GO:0008615; Biological process: pyridoxine biosynthetic process.
end case
From: SERC_ECOLI (P23721) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION (Optional)
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76
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77
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Pyridoxal phosphate binding
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[GA]-[RST]
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REGION (Optional)
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239
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240
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Pyridoxal phosphate binding
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N-T
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BINDING (Optional)
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9
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9
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L-glutamate
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S
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BINDING (Optional)
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42
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42
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L-glutamate
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R
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BINDING
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102
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102
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Pyridoxal phosphate
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[WF]
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BINDING
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153
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153
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Pyridoxal phosphate
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T
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BINDING (Optional)
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174
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174
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Pyridoxal phosphate
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D
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BINDING
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197
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197
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Pyridoxal phosphate
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Q
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MOD_RES
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198
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198
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N6-(pyridoxal phosphate)lysine
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K
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Additional information
[?]
Size range |
355-378 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
SerC is not involved in pyridoxine biosynthesis in B.subtilis, and probably also in other Firmicutes. In these organisms, pyridoxal phosphate biosynthesis is achieved by an alternative pathway involving pdxS(yaaD) and pdxT(yaaE). SerC from Mycobacterium species are slightly divergent and could have a different activity. |