HAMAP rule MF_00169

General rule information [?]

Accession	MF_00169
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 36)

Name

AroQ

Scope

Bacteria

Templates

P15474 (AROQ_STRCO); Q48255 (AROQ_HELPY); P9WPX7 (AROQ_MYCTU); P46380 (AROQ_AMYME); P54517 (AROQ_BACSU); P43877 (AROQ_ACTPL): [Recover all]

case <OC:Bacteria>

Triggered by

HAMAP; MF_00169 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

AROQ

Protein name

RecName:		Full=3-dehydroquinate dehydratase;
		Short=3-dehydroquinase;
		EC 4.2.1.10;
AltName:		Full=Type II DHQase;

Gene name

aroQ

Comments [?]

Function	Catalyzes a trans-dehydration via an enolate intermediate.
Catalytic activity	RHEA:21096: 3-dehydroquinate = 3-dehydroshikimate + H2O EC 4.2.1.10
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Subunit	Homododecamer.
Similarity	Belongs to the type-II 3-dehydroquinase family.

Keywords [?]

Amino-acid biosynthesis
Aromatic amino acid biosynthesis
Lyase

Gene Ontology [?]

GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

Cross-references [?]

Pfam	PF01220; DHquinase_II; 1;
NCBIfam	TIGR01088; AroQ; 1;
PROSITE	PS01029; DEHYDROQUINASE_II; 1;

Features [?]

From: AROQ_STRCO (P15474)

Key From To Description Tag Condition FTGroup

BINDING 108 109 /ligand="substrate [LIVM]-[ST]

ACT_SITE 29 29 Proton acceptor Y

ACT_SITE 107 107 Proton donor H

BINDING 80 80 /ligand="substrate N

BINDING 86 86 /ligand="substrate H

BINDING 93 93 /ligand="substrate D

BINDING 118 118 /ligand="substrate R

SITE 24 24 Transition state stabilizer R

Additional information [?]

Size range	143-170 amino acids
Related rules	None
Fusion	None
Comments	There are two type of DHQases, B.subtilis seems to have both

View rule in raw text format (no links)