HAMAP rule MF_00169
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_00169 |
| Accession | MF_00169 |
| Dates | 28-FEB-2005 (Created)
12-MAR-2024 (Last updated, Version 29) |
| Name | AroQ |
| Scope(s) |
Bacteria |
| Template(s) | P15474; Q48255; P9WPX7; P46380; P54517; P43877; [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_00169 (Get profile general information and statistics) end case
|
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | AROQ |
| Protein name | RecName: Full=3-dehydroquinate dehydratase; Short=3-dehydroquinase; EC=4.2.1.10; AltName: Full=Type II DHQase; |
| Gene name | Name=aroQ; |
Comments
[?]
| FUNCTION | Catalyzes a trans-dehydration via an enolate intermediate. |
| CATALYTIC ACTIVITY | Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xref=Rhea:RHEA:21096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:32364; EC=4.2.1.10; |
| PATHWAY | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. |
| SUBUNIT | Homododecamer. |
| SIMILARITY | Belongs to the type-II 3-dehydroquinase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0003855; Molecular function:3-dehydroquinate dehydratase activity |
| GO:0009423; Biological process:chorismate biosynthetic process |
Cross-references
[?]
Features
[?]
| From: AROQ_STRCO (P15474) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 108 | 109 | /ligand="substrate" | [LIVM]-[ST] | ||||||||
| ACT_SITE | 29 | 29 | /note="Proton acceptor" | Y | ||||||||
| ACT_SITE | 107 | 107 | /note="Proton donor" | H | ||||||||
| BINDING | 80 | 80 | /ligand="substrate" | N | ||||||||
| BINDING | 86 | 86 | /ligand="substrate" | H | ||||||||
| BINDING | 93 | 93 | /ligand="substrate" | D | ||||||||
| BINDING | 118 | 118 | /ligand="substrate" | R | ||||||||
| SITE | 24 | 24 | /note="Transition state stabilizer" | R | ||||||||
Additional information
[?]
| Size range | 143-170 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | There are two type of DHQases, B.subtilis seems to have both |