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HAMAP rule MF_00169

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General rule information [?]

Accession MF_00169
Dates 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 38)
Name AroQ
Scope(s) Bacteria
Template(s) P15474 (AROQ_STRCO); Q48255 (AROQ_HELPY); P9WPX7 (AROQ_MYCTU); P46380 (AROQ_AMYME); P54517 (AROQ_BACSU); P43877 (AROQ_ACTPL); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00169 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AROQ
Protein name RecName: Full=3-dehydroquinate dehydratase;
AltName: Full=Type II DHQase;
Gene name Name=aroQ;

Comments [?]

FUNCTIONCatalyzes a trans-dehydration via an enolate intermediate.
CATALYTIC ACTIVITY Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xref=Rhea:RHEA:21096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:32364; EC=;
PATHWAYMetabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
SIMILARITYBelongs to the type-II 3-dehydroquinase family.

Keywords [?]

Gene Ontology [?]

GO:0003855; Molecular function:3-dehydroquinate dehydratase activity
GO:0009423; Biological process:chorismate biosynthetic process

Cross-references [?]

Pfam PF01220; DHquinase_II; 1;
NCBIfam TIGR01088; AroQ; 1;

Features [?]

From: AROQ_STRCO (P15474)
Key From To Description Tag Condition FTGroup
BINDING 108 109 /ligand="substrate" [LIVM]-[ST]
ACT_SITE 29 29 /note="Proton acceptor" Y
ACT_SITE 107 107 /note="Proton donor" H
BINDING 80 80 /ligand="substrate" N
BINDING 86 86 /ligand="substrate" H
BINDING 93 93 /ligand="substrate" D
BINDING 118 118 /ligand="substrate" R
SITE 24 24 /note="Transition state stabilizer" R

Additional information [?]

Size range 143-170 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments There are two type of DHQases, B.subtilis seems to have both

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