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Annotation rule MF_00169
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General rule information [?]

Accession MF_00169
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 33)
Name AroQ
Scope
Bacteria
Templates P15474 (AROQ_STRCO); Q48255 (AROQ_HELPY); P9WPX7 (AROQ_MYCTU); P46380 (AROQ_AMYME); P54517 (AROQ_BACSU); P43877 (AROQ_ACTPL): [Recover all]
case <OC:Bacteria>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AROQ
Protein name
RecName: Full=3-dehydroquinate dehydratase;
Short=3-dehydroquinase;
EC 4.2.1.10;
AltName: Full=Type II DHQase;
Gene name
aroQ

Comments [?]

Function Catalyzes a trans-dehydration via an enolate intermediate.
Catalytic activity RHEA:21096: 3-dehydroquinate = 3-dehydroshikimate + H2O
EC 4.2.1.10
Pathway Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Subunit Homododecamer.
Similarity Belongs to the type-II 3-dehydroquinase family.

Keywords [?]


Gene Ontology [?]

GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

Cross-references [?]

Pfam PF01220; DHquinase_II; 1;
TIGRFAMs TIGR01088; AroQ; 1;
PROSITE PS01029; DEHYDROQUINASE_II; 1;

Features [?]

From: AROQ_STRCO (P15474)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     108     109       Substrate binding     [LIVM]-[ST]  
ACT_SITE     29     29       Proton acceptor     Y  
ACT_SITE     107     107       Proton donor     H  
BINDING     80     80       Substrate     N  
BINDING     86     86       Substrate     H  
BINDING     93     93       Substrate     D  
BINDING     118     118       Substrate     R  
SITE     24     24       Transition state stabilizer     R  

Additional information [?]

Size range 143-170 amino acids
Related rules None
Fusion None
Comments There are two type of DHQases, B.subtilis seems to have both