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Annotation rule MF_00179 |
General rule information
[?]
Accession |
MF_00179 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 26) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=GTP cyclohydrolase-2;
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EC 3.5.4.25;
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AltName:
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Full=GTP cyclohydrolase II;
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Function |
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. |
Catalytic activity |
RHEA:23704: GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+)
EC 3.5.4.25
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Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
Pathway |
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4. |
case <OC:Enterobacterales>
end case
Similarity |
Belongs to the GTP cyclohydrolase II family. |
GO:0003935; Molecular function: GTP cyclohydrolase II activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0009231; Biological process: riboflavin biosynthetic process.
From: RIBA_ECOLI (P0A7I7) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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49
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53
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GTP
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NP_BIND
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92
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94
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GTP
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E-G-R
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ACT_SITE
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126
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126
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Proton acceptor
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D
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ACT_SITE
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128
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128
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Nucleophile
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R
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METAL
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54
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54
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Zinc; catalytic
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C
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METAL
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65
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65
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Zinc; catalytic
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C
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METAL
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67
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67
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Zinc; catalytic
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C
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BINDING (Optional)
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70
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70
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GTP
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Q
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BINDING
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114
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114
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GTP
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T
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BINDING
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149
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149
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GTP
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[TS]
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BINDING
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154
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154
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GTP
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K
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Additional information
[?]
Size range |
192-222 amino acids |
Related rules |
MF_01283 (RIBBA supersedes the current rule) |
Fusion |
Nter: <ribB-like>, <Unknown>; Cter: None |
Comments |
RibA and RibB are fused in some organisms (see MF_01283 for bifunctional RibBA). Some RibA are preceded by a ribB-like domain, which does not seem to code for DHBP synthase activity because it lacks all the residues important for activity. Fused with an unknown N-terminal domain in XYLFA and XYLFT. Possible wrong start in STRCO. |