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HAMAP rule MF_00183

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General rule information [?]

Accession MF_00183
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name DXP_reductoisom
Scope(s) Bacteria
Template(s) P45568 (DXR_ECOLI); Q9KGU6 (DXR_PSEAE); Q9RCT1 (DXR_SYNP6); Q9X5F2 (DXR_ZYMMO); [ Recover all ]
Triggered by HAMAP; MF_00183 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DXR
Protein name RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;
                 Short=DXP reductoisomerase;
                 EC=1.1.1.267;
AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;
AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase;
Gene name Name=dxr;

Comments [?]

FUNCTIONCatalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP).
CATALYTIC ACTIVITY Reaction=2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH; Xref=Rhea:RHEA:13717, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57792, ChEBI:CHEBI:58262, ChEBI:CHEBI:58349; EC=1.1.1.267; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13719;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
PATHWAYIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5- phosphate: step 1/6.
case <OC:Enterobacterales>
SUBUNITHomodimer.
end case
SIMILARITYBelongs to the DXR family.

Keywords [?]

Isoprene biosynthesis
Metal-binding
Manganese
Magnesium
NADP
Oxidoreductase

Gene Ontology [?]

GO:0030604; Molecular function:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0016114; Biological process:terpenoid biosynthetic process

Cross-references [?]

Pfam PF02670; DXP_reductoisom; 1;
NCBIfam TIGR00243; Dxr; 1;

Features [?]

From: DXR_ECOLI (P45568)
Key From To Description Tag Condition FTGroup
BINDING 10 10 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 T
BINDING 11 11 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 G
BINDING 12 12 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 S
BINDING 13 13 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 [IV]
BINDING 36 36 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 [GA]
BINDING 37 37 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 [KR]
BINDING 38 38 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 N
BINDING 124 124 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 [NQ]
BINDING 125 125 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 K
BINDING 126 126 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 E
BINDING 150 150 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"		 D 1
BINDING 151 151 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 S
BINDING 152 152 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 E
BINDING 152 152 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"		 E 1
BINDING 186 186 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 S
BINDING 209 209 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 H
BINDING 215 215 /ligand="NADPH"
/ligand_id="ChEBI:CHEBI:57783"		 G
BINDING 222 222 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 S
BINDING 227 227 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 N
BINDING 228 228 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 [KR]
BINDING 231 231 /ligand="1-deoxy-D-xylulose 5-phosphate"
/ligand_id="ChEBI:CHEBI:57792"		 E
BINDING 231 231 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"		 E 1

Additional information [?]

Size range 356-455 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in MANSM, PASMU and STRCO



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