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Annotation rule MF_00183
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General rule information [?]

Accession MF_00183
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 30)
Name DXP_reductoisom
Templates P45568 (DXR_ECOLI); Q9KGU6 (DXR_PSEAE); Q9RCT1 (DXR_SYNP6); Q9X5F2 (DXR_ZYMMO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;
Short=DXP reductoisomerase;
AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;
AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase;
Gene name

Comments [?]

Function Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity RHEA:13717: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
Cofactor a divalent metal cation
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.
case <OC:Enterobacterales>
Subunit Homodimer.
end case
Similarity Belongs to the DXR family.

Keywords [?]

Gene Ontology [?]

GO:0030604; Molecular function: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.

Cross-references [?]

Pfam PF02670; DXP_reductoisom; 1;
TIGRFAMs TIGR00243; Dxr; 1;

Features [?]

From: DXR_ECOLI (P45568)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     7     36       NADP        
METAL     150     150       Divalent metal cation     D   1
METAL     152     152       Divalent metal cation     E   1
METAL     231     231       Divalent metal cation     E   1
BINDING (Optional)     125     125       Substrate     K  
BINDING (Optional)     152     152       Substrate     E  
BINDING (Optional)     186     186       Substrate     S  
BINDING (Optional)     209     209       Substrate     H  
BINDING (Optional)     231     231       Substrate     E  

Additional information [?]

Size range 356-455 amino acids
Related rules None
Fusion None
Comments Possible wrong start in MANSM, PASMU and STRCO