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HAMAP rule MF_00183

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General rule information [?]

Accession MF_00183
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name DXP_reductoisom
Templates P45568 (DXR_ECOLI); Q9KGU6 (DXR_PSEAE); Q9RCT1 (DXR_SYNP6); Q9X5F2 (DXR_ZYMMO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;
Short=DXP reductoisomerase;
AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;
AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase;
Gene name

Comments [?]

Function Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity RHEA:13717: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
PhysiologicalDirection=right-to-left (RHEA:13719)
Cofactor Mg(2+)
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.
case <OC:Enterobacterales>
Subunit Homodimer.
end case
Similarity Belongs to the DXR family.

Keywords [?]

Gene Ontology [?]

GO:0030604; Molecular function: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.

Cross-references [?]

Pfam PF02670; DXP_reductoisom; 1;
NCBIfam TIGR00243; Dxr; 1;

Features [?]

From: DXR_ECOLI (P45568)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     10     10       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     T  
BINDING     11     11       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     G  
BINDING     12     12       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     S  
BINDING     13     13       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     [IV]  
BINDING (Optional)     36     36       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     [GA]  
BINDING (Optional)     37     37       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     [KR]  
BINDING     38     38       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     N  
BINDING     124     124       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     [NQ]  
BINDING     125     125       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     K  
BINDING     126     126       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     E  
BINDING     150     150       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     D   1
BINDING     151     151       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     S  
BINDING     152     152       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     E  
BINDING     152     152       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     E   1
BINDING     186     186       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     S  
BINDING     209     209       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     H  
BINDING     215     215       /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783     G  
BINDING     222     222       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     S  
BINDING     227     227       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     N  
BINDING     228     228       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     [KR]  
BINDING     231     231       /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792     E  
BINDING     231     231       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     E   1

Additional information [?]

Size range 356-455 amino acids
Related rules None
Fusion None
Comments Possible wrong start in MANSM, PASMU and STRCO