HAMAP rule MF_00183

General rule information [?]

Accession	MF_00183
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 33)

Name	DXP_reductoisom

Scope

Bacteria

Templates

P45568 (DXR_ECOLI); Q9KGU6 (DXR_PSEAE); Q9RCT1 (DXR_SYNP6); Q9X5F2 (DXR_ZYMMO): [Recover all]

Triggered by

HAMAP; MF_00183 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DXR

Protein name

RecName:		Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;
		Short=DXP reductoisomerase;
		EC 1.1.1.267;
AltName:		Full=1-deoxyxylulose-5-phosphate reductoisomerase;
AltName:		Full=2-C-methyl-D-erythritol 4-phosphate synthase;

Gene name

dxr

Comments [?]

Function	Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity	RHEA:13717: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH EC 1.1.1.267 PhysiologicalDirection=right-to-left (RHEA:13719)
Cofactor	Mg(2+) Mn(2+)
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

case <OC:Enterobacterales>

Subunit

Homodimer.

end case

Similarity

Belongs to the DXR family.

Keywords [?]

Isoprene biosynthesis
Metal-binding
Manganese
Magnesium
NADP
Oxidoreductase

Gene Ontology [?]

GO:0030604; Molecular function: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.

Cross-references [?]

Pfam	PF02670; DXP_reductoisom; 1;
NCBIfam	TIGR00243; Dxr; 1;

Features [?]

From: DXR_ECOLI (P45568)

Key From To Description Tag Condition FTGroup

BINDING 10 10 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 T

BINDING 11 11 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 G

BINDING 12 12 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 S

BINDING 13 13 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 [IV]

BINDING (Optional) 36 36 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 [GA]

BINDING (Optional) 37 37 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 [KR]

BINDING 38 38 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 N

BINDING 124 124 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 [NQ]

BINDING 125 125 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 K

BINDING 126 126 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 E

BINDING 150 150 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 D 1

BINDING 151 151 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 S

BINDING 152 152 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 E

BINDING 152 152 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 E 1

BINDING 186 186 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 S

BINDING 209 209 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 H

BINDING 215 215 /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783 G

BINDING 222 222 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 S

BINDING 227 227 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 N

BINDING 228 228 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 [KR]

BINDING 231 231 /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792 E

BINDING 231 231 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 E 1

Additional information [?]

Size range	356-455 amino acids
Related rules	None
Fusion	None
Comments	Possible wrong start in MANSM, PASMU and STRCO

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