HAMAP rule MF_00183
General rule information
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Accession | MF_00183 |
Dates | 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 34) |
Name | DXP_reductoisom |
Scope(s) |
Bacteria |
Template(s) | P45568 (DXR_ECOLI); Q9KGU6 (DXR_PSEAE); Q9RCT1 (DXR_SYNP6); Q9X5F2 (DXR_ZYMMO); [ Recover all ] |
Triggered by |
HAMAP; MF_00183 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DXR |
Protein name | RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase; Short=DXP reductoisomerase; EC=1.1.1.267; AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase; AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase; |
Gene name | Name=dxr; |
Comments
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FUNCTION | Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). |
CATALYTIC ACTIVITY | Reaction=2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH; Xref=Rhea:RHEA:13717, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57792, ChEBI:CHEBI:58262, ChEBI:CHEBI:58349; EC=1.1.1.267; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13719; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
PATHWAY | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5- phosphate: step 1/6. |
case <OC:Enterobacterales> | |
SUBUNIT | Homodimer. |
end case | |
SIMILARITY | Belongs to the DXR family. |
Keywords
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Gene Ontology
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GO:0030604; Molecular function:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
GO:0019288; Biological process:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
Cross-references
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Features
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From: DXR_ECOLI (P45568) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 10 | 10 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
T | ||||||||
BINDING | 11 | 11 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
G | ||||||||
BINDING | 12 | 12 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
S | ||||||||
BINDING | 13 | 13 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
[IV] | ||||||||
BINDING | 36 | 36 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
[GA] | ||||||||
BINDING | 37 | 37 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
[KR] | ||||||||
BINDING | 38 | 38 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
N | ||||||||
BINDING | 124 | 124 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
[NQ] | ||||||||
BINDING | 125 | 125 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
K | ||||||||
BINDING | 126 | 126 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
E | ||||||||
BINDING | 150 | 150 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
D | 1 | |||||||
BINDING | 151 | 151 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
S | ||||||||
BINDING | 152 | 152 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
E | ||||||||
BINDING | 152 | 152 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | 1 | |||||||
BINDING | 186 | 186 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
S | ||||||||
BINDING | 209 | 209 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
H | ||||||||
BINDING | 215 | 215 | /ligand="NADPH" /ligand_id="ChEBI:CHEBI:57783" |
G | ||||||||
BINDING | 222 | 222 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
S | ||||||||
BINDING | 227 | 227 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
N | ||||||||
BINDING | 228 | 228 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
[KR] | ||||||||
BINDING | 231 | 231 | /ligand="1-deoxy-D-xylulose 5-phosphate" /ligand_id="ChEBI:CHEBI:57792" |
E | ||||||||
BINDING | 231 | 231 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | 1 |
Additional information
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Size range | 356-455 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Possible wrong start in MANSM, PASMU and STRCO |