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HAMAP rule MF_00198
General rule information
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Accession | MF_00198 |
Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 47) |
Name | Spermidine_synth |
Scope(s) |
Bacteria Archaea |
Template(s) | P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY); O57950 (SPEE_PYRHO); Q9UXE4 (SPEE_SACS2); Q5JFG9 (SPEE_THEKO); Q5SK28 (SPEE_THET8); [ Recover all ] |
Triggered by |
HAMAP; MF_00198 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | SPEE |
Protein name | RecName: Full=Polyamine aminopropyltransferase; AltName: Full=Spermidine synthase; Short=SPDSY; Short=SPDS; EC=2.5.1.16; AltName: Full=Putrescine aminopropyltransferase; Short=PAPT; |
Gene name | Name=speE; |
Comments
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FUNCTION | Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. |
CATALYTIC ACTIVITY | Reaction=putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine; Xref=Rhea:RHEA:12721, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:57443, ChEBI:CHEBI:57834, ChEBI:CHEBI:326268; EC=2.5.1.16; |
PATHWAY | Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. |
case <Feature:Transmembrane>1> | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
else case <Feature:Transmembrane==1> | |
SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
else | |
SUBCELLULAR LOCATION | Cytoplasm. |
end case | |
SUBUNIT | Homodimer or homotetramer. |
SIMILARITY | Belongs to the spermidine/spermine synthase family. |
case not <FTTag:Act_site> | |
CAUTION | Lacks the conserved Asp active site. |
end case |
Keywords
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Polyamine biosynthesis | |
Spermidine biosynthesis | |
Transferase | |
case <Feature:Transmembrane>1> | |
Cell membrane | |
Membrane | |
Transmembrane | |
Transmembrane helix | |
else | |
Cytoplasm | |
end case |
Gene Ontology
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GO:0004766; Molecular function:spermidine synthase activity |
GO:0008295; Biological process:spermidine biosynthetic process |
Cross-references
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Pfam | PF01564; Spermine_synth; 1; |
NCBIfam | TIGR00417; SpeE; 1; |
PROSITE | PS01330; PABS_1; 1; |
PROSITE | PS51006; PABS_2; 1; |
General | Transmembrane; -; 7; |
Features
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From: SPEE_PYRHO (O57950) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 144 | 145 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509" |
[DNE]-[AGV] | ||||||||
BINDING | 161 | 164 | /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834" |
D-[SC]-x-[DNE] | ||||||||
ACT_SITE | 161 | 161 | /note="Proton acceptor" | Act_site | D | |||||||
BINDING | 32 | 32 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509" |
[QNR] | ||||||||
BINDING | 63 | 63 | /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834" |
H | ||||||||
BINDING | 87 | 87 | /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834" |
[DNE] | ||||||||
BINDING | 107 | 107 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509" |
[ED] | ||||||||
BINDING | 168 | 168 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509" |
P |
Additional information
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Size range | 261-574 amino acids |
Related rules |
None |
Fusion | Nter: <Unknown> Cter: <Unknown> |