HAMAP rule MF_00198
General rule information
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Accession | MF_00198 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 45) |
Name | Spermidine_synth |
Scope | Bacteria
Archaea |
Templates | P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY); O57950 (SPEE_PYRHO); Q9UXE4 (SPEE_SACS2); Q5JFG9 (SPEE_THEKO); Q5SK28 (SPEE_THET8): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
|
Gene name |
|
Comments
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Function | Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. |
Catalytic activity | RHEA:12721: putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine
EC 2.5.1.16 |
Pathway | Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. |
case <Feature:Transmembrane>1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Feature:Transmembrane==1>
Subcellular location | Cell membrane; Single-pass membrane protein. |
else
Subcellular location | Cytoplasm. |
end case
Subunit | Homodimer or homotetramer. |
Similarity | Belongs to the spermidine/spermine synthase family. |
case not <FTTag:Act_site>
Caution | Lacks the conserved Asp active site. |
end case
Keywords
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case <Feature:Transmembrane>1>
else
end case
Gene Ontology
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GO:0004766; Molecular function: spermidine synthase activity.
GO:0008295; Biological process: spermidine biosynthetic process.
GO:0008295; Biological process: spermidine biosynthetic process.
Cross-references
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Pfam | PF01564; Spermine_synth; 1; |
TIGRFAMs | TIGR00417; SpeE; 1; |
PROSITE | PS01330; PABS_1; 1; |
PS51006; PABS_2; 1; trigger=PRU00354; |
Computed features
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General | Transmembrane; -; 7; trigger=yes; |
Features
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From: SPEE_PYRHO (O57950) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 144 | 145 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509 | [DNE]-[AGV] | ||||||||
BINDING (Optional) | 161 | 164 | /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834 | D-[SC]-x-[DNE] | ||||||||
ACT_SITE | 161 | 161 | Proton acceptor | Act_site | D | |||||||
BINDING (Optional) | 32 | 32 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509 | [QNR] | ||||||||
BINDING (Optional) | 63 | 63 | /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834 | H | ||||||||
BINDING (Optional) | 87 | 87 | /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834 | [DNE] | ||||||||
BINDING (Optional) | 107 | 107 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509 | [ED] | ||||||||
BINDING (Optional) | 168 | 168 | /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509 | P |
Additional information
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Size range | 261-574 amino acids |
Related rules | None |
Fusion | Nter: <Unknown>; Cter: <Unknown> |