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HAMAP rule MF_00198

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General rule information [?]

Accession MF_00198
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 45)
Name Spermidine_synth
Scope
Bacteria
Archaea
Templates P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY); O57950 (SPEE_PYRHO); Q9UXE4 (SPEE_SACS2); Q5JFG9 (SPEE_THEKO); Q5SK28 (SPEE_THET8): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SPEE
Protein name
RecName: Full=Polyamine aminopropyltransferase;
AltName: Full=Spermidine synthase;
Short=SPDSY;
Short=SPDS;
EC 2.5.1.16;
AltName: Full=Putrescine aminopropyltransferase;
Short=PAPT;
Gene name
speE

Comments [?]

Function Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Catalytic activity RHEA:12721: putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine
EC 2.5.1.16
Pathway Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
case <Feature:Transmembrane>1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Feature:Transmembrane==1>
Subcellular location Cell membrane; Single-pass membrane protein.
else
Subcellular location Cytoplasm.
end case
Subunit Homodimer or homotetramer.
Similarity Belongs to the spermidine/spermine synthase family.
case not <FTTag:Act_site>
Caution Lacks the conserved Asp active site.
end case

Keywords [?]

Polyamine biosynthesis
Spermidine biosynthesis
Transferase
case <Feature:Transmembrane>1>
Cell membrane
Membrane
Transmembrane
Transmembrane helix
else
Cytoplasm
end case

Gene Ontology [?]

GO:0004766; Molecular function: spermidine synthase activity.
GO:0008295; Biological process: spermidine biosynthetic process.

Cross-references [?]

Pfam PF01564; Spermine_synth; 1;
TIGRFAMs TIGR00417; SpeE; 1;
PROSITE PS01330; PABS_1; 1;
PS51006; PABS_2; 1; trigger=PRU00354;

Computed features [?]

General Transmembrane; -; 7; trigger=yes;

Features [?]

From: SPEE_PYRHO (O57950)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     144     145       /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509     [DNE]-[AGV]  
BINDING (Optional)     161     164       /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834     D-[SC]-x-[DNE]  
ACT_SITE     161     161       Proton acceptor   Act_site   D  
BINDING (Optional)     32     32       /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509     [QNR]  
BINDING (Optional)     63     63       /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834     H  
BINDING (Optional)     87     87       /ligand="spermidine" /ligand_id="ChEBI:CHEBI:57834     [DNE]  
BINDING (Optional)     107     107       /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509     [ED]  
BINDING (Optional)     168     168       /ligand="S-methyl-5'-thioadenosine" /ligand_id="ChEBI:CHEBI:17509     P  

Additional information [?]

Size range 261-574 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: <Unknown>


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