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Annotation rule MF_00198 |
General rule information
[?]
Accession |
MF_00198 |
Dates |
1-JUN-2001 (Created) 14-MAY-2022 (Last updated, Version 44) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=Polyamine aminopropyltransferase;
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AltName:
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Full=Spermidine synthase;
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Short=SPDSY;
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Short=SPDS;
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EC 2.5.1.16;
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AltName:
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Full=Putrescine aminopropyltransferase;
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Short=PAPT;
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Function |
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. |
Catalytic activity |
RHEA:12721: putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine
EC 2.5.1.16
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Pathway |
Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. |
case <Feature:Transmembrane>1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Feature:Transmembrane==1>
Subcellular location |
Cell membrane; Single-pass membrane protein. |
else
Subcellular location |
Cytoplasm. |
end case
Subunit |
Homodimer or homotetramer. |
Similarity |
Belongs to the spermidine/spermine synthase family. |
case not <FTTag:Act_site>
Caution |
Lacks the conserved Asp active site. |
end case
case <Feature:Transmembrane>1>
else
end case
GO:0004766; Molecular function: spermidine synthase activity.
GO:0008295; Biological process: spermidine biosynthetic process.
General |
Transmembrane; -; 7; trigger=yes; |
From: SPEE_PYRHO (O57950) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING (Optional)
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144
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145
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/ligand="S-methyl-5'-thioadenosine" /ligand_id="17509
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[DNE]-[AGV]
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BINDING (Optional)
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161
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164
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/ligand="spermidine" /ligand_id="57834
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D-[SC]-x-[DNE]
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ACT_SITE
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161
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161
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Proton acceptor
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Act_site
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D
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BINDING (Optional)
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32
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32
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/ligand="S-methyl-5'-thioadenosine" /ligand_id="17509
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[QNR]
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BINDING (Optional)
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63
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63
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/ligand="spermidine" /ligand_id="57834
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H
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BINDING (Optional)
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87
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87
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/ligand="spermidine" /ligand_id="57834
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[DNE]
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BINDING (Optional)
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107
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107
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/ligand="S-methyl-5'-thioadenosine" /ligand_id="17509
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[ED]
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BINDING (Optional)
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168
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168
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/ligand="S-methyl-5'-thioadenosine" /ligand_id="17509
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P
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Additional information
[?]
Size range |
261-574 amino acids |
Related rules |
None |
Fusion |
Nter: <Unknown>; Cter: <Unknown> |