HAMAP logo

HAMAP rule MF_00198

Send feedback

General rule information [?]

Accession MF_00198
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 47)
Name Spermidine_synth
Scope(s) Bacteria
Template(s) P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY); O57950 (SPEE_PYRHO); Q9UXE4 (SPEE_SACS2); Q5JFG9 (SPEE_THEKO); Q5SK28 (SPEE_THET8); [ Recover all ]
Triggered by HAMAP; MF_00198 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SPEE
Protein name RecName: Full=Polyamine aminopropyltransferase;
AltName: Full=Spermidine synthase;
AltName: Full=Putrescine aminopropyltransferase;
Gene name Name=speE;

Comments [?]

FUNCTIONCatalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
CATALYTIC ACTIVITY Reaction=putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine; Xref=Rhea:RHEA:12721, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:57443, ChEBI:CHEBI:57834, ChEBI:CHEBI:326268; EC=;
PATHWAYAmine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
case <Feature:Transmembrane>1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Feature:Transmembrane==1>
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
end case
SUBUNITHomodimer or homotetramer.
SIMILARITYBelongs to the spermidine/spermine synthase family.
case not <FTTag:Act_site>
CAUTIONLacks the conserved Asp active site.
end case

Keywords [?]

Gene Ontology [?]

GO:0004766; Molecular function:spermidine synthase activity
GO:0008295; Biological process:spermidine biosynthetic process

Cross-references [?]

Pfam PF01564; Spermine_synth; 1;
NCBIfam TIGR00417; SpeE; 1;
PROSITE PS01330; PABS_1; 1;
PROSITE PS51006; PABS_2; 1;
General Transmembrane; -; 7;

Features [?]

From: SPEE_PYRHO (O57950)
Key From To Description Tag Condition FTGroup
BINDING 144 145 /ligand="S-methyl-5'-thioadenosine"
BINDING 161 164 /ligand="spermidine"
ACT_SITE 161 161 /note="Proton acceptor" Act_site D
BINDING 32 32 /ligand="S-methyl-5'-thioadenosine"
BINDING 63 63 /ligand="spermidine"
BINDING 87 87 /ligand="spermidine"
BINDING 107 107 /ligand="S-methyl-5'-thioadenosine"
BINDING 168 168 /ligand="S-methyl-5'-thioadenosine"

Additional information [?]

Size range 261-574 amino acids
Related rules None
Fusion Nter: <Unknown> Cter: <Unknown>

View rule in raw text format (no links)