HAMAP rule MF_00202
General rule information
[?]
Accession | MF_00202 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 41) |
Name | Idi |
Scope | Bacteria; Actinomycetota
Bacteria; Pseudomonadota
Archaea; Halobacteria |
Template | Q46822 (IDI_ECOLI) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). |
Catalytic activity | RHEA:23284: isopentenyl diphosphate = dimethylallyl diphosphate
EC 5.3.3.2 |
case <FT:6>
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound. |
end case
case <FTGroup:1>
Cofactor | Mn(2+) Note: Binds 1 Mn(2+) ion per subunit. |
end case
Pathway | Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. |
case <Property:PHOTOSYN>
Pathway | Porphyrin-containing compound metabolism; chlorophyll biosynthesis. |
end case
case <OC:Enterobacterales>
Subunit | Homodimer. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the IPP isomerase type 1 family. |
Keywords
[?]
case <Property:PHOTOSYN>
end case
case <FT:6>
end case
case <FTGroup:1>
end case
case <FTGroup:1> or <FT:6>
end case
Gene Ontology
[?]
GO:0004452; Molecular function: isopentenyl-diphosphate delta-isomerase activity.
case <Property:PHOTOSYN>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case
GO:0008299; Biological process: isoprenoid biosynthetic process.
case <Property:PHOTOSYN>
GO:0015979; Biological process: photosynthesis.
end case
GO:0005737; Cellular component: cytoplasm.
Cross-references
[?]
Features
[?]
From: IDI_ECOLI (Q46822) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 67 | 67 | C | |||||||||
ACT_SITE | 116 | 116 | E | |||||||||
BINDING | 25 | 25 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | H | 1 | |||||||
BINDING | 32 | 32 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | H | 1 | |||||||
BINDING | 69 | 69 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | H | 1 | |||||||
BINDING | 87 | 87 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | ||||||||
BINDING | 114 | 114 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | E | 1 | |||||||
BINDING | 116 | 116 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | E | 1 |
Additional information
[?]
Size range | 175-213 amino acids |
Related rules | None |
Fusion | None |
Comments | HALSA and HALMA putative conserved active site cysteine residue is replaced by an alanine. HALSA also possess a type-2 IDI. |