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HAMAP rule MF_00202

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General rule information [?]

Accession MF_00202
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name Idi
Bacteria; Actinomycetota
Bacteria; Pseudomonadota
Archaea; Halobacteria
Template Q46822 (IDI_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Isopentenyl-diphosphate Delta-isomerase;
Short=IPP isomerase;
AltName: Full=IPP:DMAPP isomerase;
AltName: Full=Isopentenyl pyrophosphate isomerase;
Gene name

Comments [?]

Function Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Catalytic activity RHEA:23284: isopentenyl diphosphate = dimethylallyl diphosphate
case <FT:6>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
end case
case <FTGroup:1>
Cofactor Mn(2+)
Note: Binds 1 Mn(2+) ion per subunit.
end case
Pathway Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
case <Property:PHOTOSYN>
Pathway Porphyrin-containing compound metabolism; chlorophyll biosynthesis.
end case
case <OC:Enterobacterales>
Subunit Homodimer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the IPP isomerase type 1 family.

Keywords [?]

case <Property:PHOTOSYN>
end case
case <FT:6>
end case
case <FTGroup:1>
end case
case <FTGroup:1> or <FT:6>
end case

Gene Ontology [?]

GO:0004452; Molecular function: isopentenyl-diphosphate delta-isomerase activity.
case <Property:PHOTOSYN>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case
GO:0008299; Biological process: isoprenoid biosynthetic process.
case <Property:PHOTOSYN>
GO:0015979; Biological process: photosynthesis.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00293; NUDIX; 1;
NCBIfam TIGR02150; IPP_isom_1; 1;

Features [?]

From: IDI_ECOLI (Q46822)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     67     67             C  
ACT_SITE     116     116             E  
BINDING     25     25       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     H   1
BINDING     32     32       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     H   1
BINDING     69     69       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     H   1
BINDING     87     87       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E  
BINDING     114     114       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     E   1
BINDING     116     116       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     E   1

Additional information [?]

Size range 175-213 amino acids
Related rules None
Fusion None
Comments HALSA and HALMA putative conserved active site cysteine residue is replaced by an alanine. HALSA also possess a type-2 IDI.