HAMAP rule MF_00203

Accession	MF_00203
Dates	1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 28)

Name

UvrC

Scope

Bacteria Archaea

Template

P0A8G0 (UVRC_ECOLI)

Triggered by

HAMAP; MF_00203 (Get profile general information and statistics)

Identifier

UVRC

Protein name

RecName: Full=UvrABC system protein C; Short=Protein UvrC; AltName: Full=Excinuclease ABC subunit C;

Gene name

uvrC

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subunit	Interacts with UvrB in an incision complex.
Subcellular location	Cytoplasm.
Similarity	Belongs to the UvrC family.

Cytoplasm
DNA damage
SOS response
Excision nuclease
DNA repair
DNA excision

GO:0003677; Molecular function: DNA binding.
GO:0009381; Molecular function: excinuclease ABC activity.
GO:0006281; Biological process: DNA repair.
GO:0006289; Biological process: nucleotide-excision repair.
GO:0009432; Biological process: SOS response.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF01541; GIY-YIG; 1;
	PF02151; UVR; 1;
	PF08459; UvrC_HhH_N; 1;
TIGRFAMs	TIGR00194; UvrC; 1;
PROSITE	PS50164; GIY_YIG; 1; trigger=PRU00977;
	PS50151; UVR; 0-1; trigger=PRU00217;
	PS50165; UVRC; 1;

Size range	519-747 amino acids
Related rules	None
Fusion	None
Comments	Weird insertions in STRCO and TREPA

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