HAMAP rule MF_00211
General rule information
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Accession | MF_00211 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 39) |
Name | TrpD |
Scope | Bacteria
Archaea |
Templates | P50384 (TRPD_SACS2); P9WFX5 (TRPD_MYCTU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA). |
Catalytic activity | RHEA:11768: diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
EC 2.4.2.18 |
Cofactor | Mg(2+) Note: Binds 2 magnesium ions per monomer. |
Pathway | Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. |
Subunit | Homodimer. |
Similarity | Belongs to the anthranilate phosphoribosyltransferase family. |
Keywords
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Amino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
Transferase
Glycosyltransferase
Magnesium
Metal-binding
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
Transferase
Glycosyltransferase
Magnesium
Metal-binding
Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0004048; Molecular function: anthranilate phosphoribosyltransferase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.
GO:0004048; Molecular function: anthranilate phosphoribosyltransferase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.
Cross-references
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Features
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From: TRPD_MYCTU (P9WFX5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 110 | 111 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | G-[DSN] | ||||||||
BINDING (Optional) | 117 | 120 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | N-x-[ST]-[TS] | ||||||||
BINDING (Optional) | 135 | 143 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | K-x(2)-[NGAS]-x(3)-[TSV]-[SG] | ||||||||
BINDING | 119 | 119 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | [ST] | ||||||||
BINDING | 251 | 251 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 | D | ||||||||
BINDING | 252 | 252 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | E | ||||||||
BINDING | 252 | 252 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 | E | ||||||||
BINDING | 107 | 107 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | G | ||||||||
BINDING | 115 | 115 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | [TS] | ||||||||
BINDING | 147 | 147 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | [GA] | ||||||||
From: TRPD_SACS2 (P50384) | ||||||||||||
BINDING | 79 | 79 | /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1 | G | ||||||||
BINDING | 109 | 109 | /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1 | N | ||||||||
BINDING | 118 | 118 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | [ST] | ||||||||
BINDING | 164 | 164 | /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="2 | R |
Additional information
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Size range | 320-370 amino acids |
Related rules | None |
Fusion | Nter: MF_00134 (trpC), <glutamine amidotransferase type-1 domain>; Cter: None |
Comments | There are divergent trpD-like proteins in AQUAE (O66585) and ECOLI (P30177) |