HAMAP rule MF_00211

General rule information [?]

Accession	MF_00211
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 39)

Name

TrpD

Scope

Bacteria

Archaea

Templates

P50384 (TRPD_SACS2); P9WFX5 (TRPD_MYCTU): [Recover all]

Triggered by

HAMAP; MF_00211 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TRPD

Protein name

RecName:		Full=Anthranilate phosphoribosyltransferase;
		EC 2.4.2.18;

Gene name

trpD

Comments [?]

Function	Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Catalytic activity	RHEA:11768: diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate EC 2.4.2.18
Cofactor	Mg(2+) Note: Binds 2 magnesium ions per monomer.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.
Subunit	Homodimer.
Similarity	Belongs to the anthranilate phosphoribosyltransferase family.

Keywords [?]

Amino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
Transferase
Glycosyltransferase
Magnesium
Metal-binding

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0004048; Molecular function: anthranilate phosphoribosyltransferase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.

Cross-references [?]

Pfam	PF00591; Glycos_transf_3; 1;
	PF02885; Glycos_trans_3N; 1;
NCBIfam	TIGR01245; TrpD; 1;

Features [?]

From: TRPD_MYCTU (P9WFX5)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 110 111 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 G-[DSN]

BINDING (Optional) 117 120 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 N-x-[ST]-[TS]

BINDING (Optional) 135 143 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 K-x(2)-[NGAS]-x(3)-[TSV]-[SG]

BINDING 119 119 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 [ST]

BINDING 251 251 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 D

BINDING 252 252 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 E

BINDING 252 252 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 E

BINDING 107 107 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 G

BINDING 115 115 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 [TS]

BINDING 147 147 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 [GA]

From: TRPD_SACS2 (P50384)

BINDING 79 79 /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1 G

BINDING 109 109 /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1 N

BINDING 118 118 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 [ST]

BINDING 164 164 /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="2 R

Additional information [?]

Size range	320-370 amino acids
Related rules	None
Fusion	Nter: MF_00134 (trpC), <glutamine amidotransferase type-1 domain>; Cter: None
Comments	There are divergent trpD-like proteins in AQUAE (O66585) and ECOLI (P30177)

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