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HAMAP rule MF_00211

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General rule information [?]

Accession MF_00211
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name TrpD
Templates P50384 (TRPD_SACS2); P9WFX5 (TRPD_MYCTU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Anthranilate phosphoribosyltransferase;
Gene name

Comments [?]

Function Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Catalytic activity RHEA:11768: diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
Cofactor Mg(2+)
Note: Binds 2 magnesium ions per monomer.
Pathway Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.
Subunit Homodimer.
Similarity Belongs to the anthranilate phosphoribosyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0004048; Molecular function: anthranilate phosphoribosyltransferase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.

Cross-references [?]

Pfam PF00591; Glycos_transf_3; 1;
PF02885; Glycos_trans_3N; 1;
NCBIfam TIGR01245; TrpD; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     110     111       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     G-[DSN]  
BINDING (Optional)     117     120       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     N-x-[ST]-[TS]  
BINDING (Optional)     135     143       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     K-x(2)-[NGAS]-x(3)-[TSV]-[SG]  
BINDING     119     119       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     [ST]  
BINDING     251     251       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     252     252       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     E  
BINDING     252     252       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     E  
BINDING     107     107       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     G  
BINDING     115     115       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     [TS]  
BINDING     147     147       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     [GA]  
From: TRPD_SACS2 (P50384)
BINDING     79     79       /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1     G  
BINDING     109     109       /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1     N  
BINDING     118     118       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     [ST]  
BINDING     164     164       /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="2     R  

Additional information [?]

Size range 320-370 amino acids
Related rules None
Fusion Nter: MF_00134 (trpC), <glutamine amidotransferase type-1 domain>; Cter: None
Comments There are divergent trpD-like proteins in AQUAE (O66585) and ECOLI (P30177)