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Annotation rule MF_00214
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General rule information [?]

Accession MF_00214
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 37)
Name AroD
Scope
Bacteria
Archaea
Templates P05194 (AROD_ECOLI); P24670 (AROD_SALTI); P58687 (AROD_SALTY); Q186A6 (AROD_CLOD6); Q6GII7 (AROD_STAAR); O30011 (AROD_ARCFU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AROD
Protein name
RecName: Full=3-dehydroquinate dehydratase;
Short=3-dehydroquinase;
EC 4.2.1.10;
AltName: Full=Type I dehydroquinase;
Short=DHQ1;
AltName: Full=Type I DHQase;
Gene name
aroD

Comments [?]

Function Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Catalytic activity RHEA:21096: 3-dehydroquinate = 3-dehydroshikimate + H2O
EC 4.2.1.10
Pathway Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Subunit Homodimer.
Similarity Belongs to the type-I 3-dehydroquinase family.

Keywords [?]


Gene Ontology [?]

GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

Cross-references [?]

Pfam PF01487; DHquinase_I; 1;
TIGRFAMs TIGR01093; AroD; 1;
PROSITE PS01028; DEHYDROQUINASE_I; 1;

Features [?]

From: AROD_SALTY (P58687)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     46     48       3-dehydroquinate binding     E-x-R  
ACT_SITE     143     143       Proton donor/acceptor     H  
ACT_SITE     170     170       Schiff-base intermediate with substrate     K  
BINDING (Optional)     21     21       3-dehydroquinate     S  
BINDING (Optional)     82     82       3-dehydroquinate     R  
BINDING (Optional)     213     213       3-dehydroquinate     R  
BINDING (Optional)     232     232       3-dehydroquinate     [ST]  
BINDING (Optional)     236     236       3-dehydroquinate     Q  

Additional information [?]

Size range 196-272 amino acids
Related rules MF_03143 (ARO1 supersedes the current rule)
Fusion Nter: None; Cter: MF_00222 (aroE), <Chorismate mutase>
Comments There are two type of DHQases, B.subtilis seems to have both. AroD can be confused with of DHQases involved in catabolism (quiB) or in other pathways (example ebsD).