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HAMAP rule MF_00214

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General rule information [?]

Accession MF_00214
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name AroD
Scope(s) Bacteria
Template(s) P05194 (AROD_ECOLI); P24670 (AROD_SALTI); P58687 (AROD_SALTY); Q186A6 (AROD_CLOD6); Q6GII7 (AROD_STAAR); O30011 (AROD_ARCFU); [ Recover all ]
Triggered by HAMAP; MF_00214 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AROD
Protein name RecName: Full=3-dehydroquinate dehydratase;
AltName: Full=Type I dehydroquinase;
AltName: Full=Type I DHQase;
Gene name Name=aroD;

Comments [?]

FUNCTIONInvolved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
CATALYTIC ACTIVITY Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xref=Rhea:RHEA:21096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:32364; EC=;
PATHWAYMetabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
SIMILARITYBelongs to the type-I 3-dehydroquinase family.

Keywords [?]

Gene Ontology [?]

GO:0003855; Molecular function:3-dehydroquinate dehydratase activity
GO:0009073; Biological process:aromatic amino acid family biosynthetic process

Cross-references [?]

Pfam PF01487; DHquinase_I; 1;
NCBIfam TIGR01093; AroD; 1;

Features [?]

From: AROD_SALTY (P58687)
Key From To Description Tag Condition FTGroup
BINDING 46 48 /ligand="3-dehydroquinate"
ACT_SITE 143 143 /note="Proton donor/acceptor" H
ACT_SITE 170 170 /note="Schiff-base intermediate with substrate" K
BINDING 21 21 /ligand="3-dehydroquinate"
BINDING 82 82 /ligand="3-dehydroquinate"
BINDING 213 213 /ligand="3-dehydroquinate"
BINDING 232 232 /ligand="3-dehydroquinate"
BINDING 236 236 /ligand="3-dehydroquinate"

Additional information [?]

Size range 196-272 amino acids
Related rules MF_03143
Fusion Nter: None Cter: MF_00222 (aroE); <Chorismate mutase>
Comments There are two type of DHQases, B.subtilis seems to have both. AroD can be confused with of DHQases involved in catabolism (quiB) or in other pathways (example ebsD).

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