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HAMAP rule MF_00223

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General rule information [?]

Accession MF_00223
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name FolE
Scope(s) Bacteria
Template(s) P0A6T5 (GCH1_ECOLI); P19465 (GCH1_BACSU); [ Recover all ]
Triggered by HAMAP; MF_00223 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GCH1
Protein name RecName: Full=GTP cyclohydrolase 1;
AltName: Full=GTP cyclohydrolase I;
Gene name Name=folE;

Comments [?]

CATALYTIC ACTIVITY Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=;
PATHWAYCofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
SIMILARITYBelongs to the GTP cyclohydrolase I family.

Keywords [?]

Gene Ontology [?]

GO:0003934; Molecular function:GTP cyclohydrolase I activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0006730; Biological process:one-carbon metabolic process
GO:0046654; Biological process:tetrahydrofolate biosynthetic process

Cross-references [?]

Pfam PF01227; GTP_cyclohydroI; 1;
NCBIfam TIGR00063; FolE; 1;

Features [?]

From: GCH1_ECOLI (P0A6T5)
Key From To Description Tag Condition FTGroup
BINDING 111 111 /ligand="Zn(2+)"
C 1
BINDING 114 114 /ligand="Zn(2+)"
H 1
BINDING 182 182 /ligand="Zn(2+)"
C 1

Additional information [?]

Size range 180-235 amino acids
Related rules None
Fusion Nter: MF_xxxxx (folK) Cter: None
Comments The GTP cyclohydrolases of this family share the same function as the bacterial GTP cyclohydrolases of the MF_01527 family (GTP cyclohydrolases folE2), without having any sequence homology.

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