 |
|
Annotation rule MF_00223 |
General rule information
[?]
Accession |
MF_00223 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 38) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=GTP cyclohydrolase 1;
|
|
EC 3.5.4.16;
|
AltName:
|
Full=GTP cyclohydrolase I;
|
|
Short=GTP-CH-I;
|
|
Catalytic activity |
RHEA:17473: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)
EC 3.5.4.16
|
Pathway |
Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. |
Subunit |
Homopolymer. |
Similarity |
Belongs to the GTP cyclohydrolase I family. |
case <FTGroup:1>
end case
GO:0003934; Molecular function: GTP cyclohydrolase I activity.
case <FTGroup:1>
end case
GO:0006730; Biological process: one-carbon metabolic process.
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.
From: GCH1_ECOLI (P0A6T5) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
METAL
|
|
111
|
|
111
|
|
Zinc
|
|
|
|
C
|
|
1
|
METAL
|
|
114
|
|
114
|
|
Zinc
|
|
|
|
H
|
|
1
|
METAL
|
|
182
|
|
182
|
|
Zinc
|
|
|
|
C
|
|
1
|
Additional information
[?]
Size range |
180-235 amino acids |
Related rules |
None |
Fusion |
Nter: MF_xxxxx (folK); Cter: None |
Comments |
The GTP cyclohydrolases of this family share the same function as the bacterial GTP cyclohydrolases of the MF_01527 family (GTP cyclohydrolases folE2), without having any sequence homology. |