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Annotation rule MF_00223
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General rule information [?]

Accession MF_00223
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 38)
Name FolE
Scope
Bacteria
Archaea
Templates P0A6T5 (GCH1_ECOLI); P19465 (GCH1_BACSU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GCH1
Protein name
RecName: Full=GTP cyclohydrolase 1;
EC 3.5.4.16;
AltName: Full=GTP cyclohydrolase I;
Short=GTP-CH-I;
Gene name
folE

Comments [?]

Catalytic activity RHEA:17473: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)
EC 3.5.4.16
Pathway Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Subunit Homopolymer.
Similarity Belongs to the GTP cyclohydrolase I family.

Keywords [?]

GTP-binding
Nucleotide-binding
One-carbon metabolism
Hydrolase
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0003934; Molecular function: GTP cyclohydrolase I activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0006730; Biological process: one-carbon metabolic process.
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.

Cross-references [?]

Pfam PF01227; GTP_cyclohydroI; 1;
TIGRFAMs TIGR00063; FolE; 1;
PROSITE PS00859; GTP_CYCLOHYDROL_1_1; 1;
PS00860; GTP_CYCLOHYDROL_1_2; 1;

Features [?]

From: GCH1_ECOLI (P0A6T5)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     111     111       Zinc     C   1
METAL     114     114       Zinc     H   1
METAL     182     182       Zinc     C   1

Additional information [?]

Size range 180-235 amino acids
Related rules None
Fusion Nter: MF_xxxxx (folK); Cter: None
Comments The GTP cyclohydrolases of this family share the same function as the bacterial GTP cyclohydrolases of the MF_01527 family (GTP cyclohydrolases folE2), without having any sequence homology.


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