HAMAP rule MF_00229

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00229
Accession	MF_00229
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 24)
Name	His_ammonia_lyase
Scope(s)	Bacteria Archaea
Template(s)	P21310; [ Recover all ]
Triggered by	HAMAP; MF_00229 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HUTH
case <OC:Bacteria>
Protein name	RecName: Full=Histidine ammonia-lyase; Short=Histidase; EC=4.3.1.3;
end case
case <OC:Archaea>
Protein name	RecName: Full=Probable histidine ammonia-lyase; Short=Histidase; EC=4.3.1.3;
end case
Gene name	Name=hutH;

Comments [?]

CATALYTIC ACTIVITY	Reaction=L-histidine = trans-urocanate + NH4(+); Xref=Rhea:RHEA:21232, ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
PATHWAY	Amino-acid degradation; L-histidine degradation into L- glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
SUBCELLULAR LOCATION	Cytoplasm.
case <FT:2=A-x*>
PTM	Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
end case
case <FT:2=C-x*>
PTM	Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.
end case
case <FT:2=S-x*>
PTM	Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.
end case
SIMILARITY	Belongs to the PAL/histidase family.

Keywords [?]

Gene Ontology [?]

GO:0004397; Molecular function:histidine ammonia-lyase activity

GO:0006548; Biological process:L-histidine catabolic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: HUTH_PSEPU (P21310)

Key

From

Description

Tag

Condition

FTGroup

MOD_RES

144

/note="2,3-didehydroalanine (Ser)"

CROSSLNK

143

145

/note="5-imidazolinone (Ala-Gly)"

[CSA]-S-G

Additional information [?]