HAMAP rule MF_00229
General rule information
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Accession | MF_00229 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 33) |
Name | His_ammonia_lyase |
Scope | Bacteria
Archaea |
Template | P21310 (HUTH_PSEPU) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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case <OC:Bacteria>
Protein name |
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end case
case <OC:Archaea>
Protein name |
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end case
Gene name |
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Comments
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Catalytic activity | RHEA:21232: L-histidine = NH4(+) + trans-urocanate
EC 4.3.1.3 |
Pathway | Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. |
Subcellular location | Cytoplasm. |
case <FT:2=A-x*>
Ptm | Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. |
end case
case <FT:2=C-x*>
Ptm | Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly. |
end case
case <FT:2=S-x*>
Ptm | Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly. |
end case
Similarity | Belongs to the PAL/histidase family. |
Keywords
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Gene Ontology
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GO:0004397; Molecular function: histidine ammonia-lyase activity.
GO:0006548; Biological process: histidine catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0006548; Biological process: histidine catabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: HUTH_PSEPU (P21310) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 144 | 144 | 2,3-didehydroalanine (Ser) | S | ||||||||
CROSSLNK | 143 | 145 | 5-imidazolinone (Ala-Gly) | [CSA]-S-G |
Additional information
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Size range | 495-525 amino acids |
Related rules | None |
Fusion | Nter: MF_00372 (hutI); Cter: None |