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HAMAP rule MF_00229

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General rule information [?]

Accession MF_00229
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 33)
Name His_ammonia_lyase
Scope
Bacteria
Archaea
Template P21310 (HUTH_PSEPU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HUTH
case <OC:Bacteria>
Protein name
RecName: Full=Histidine ammonia-lyase;
Short=Histidase;
EC 4.3.1.3;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable histidine ammonia-lyase;
Short=Histidase;
EC 4.3.1.3;
end case
Gene name
hutH

Comments [?]

Catalytic activity RHEA:21232: L-histidine = NH4(+) + trans-urocanate
EC 4.3.1.3
Pathway Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
Subcellular location Cytoplasm.
case <FT:2=A-x*>
Ptm Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
end case
case <FT:2=C-x*>
Ptm Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.
end case
case <FT:2=S-x*>
Ptm Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.
end case
Similarity Belongs to the PAL/histidase family.

Keywords [?]

Cytoplasm
Lyase
Histidine metabolism

Gene Ontology [?]

GO:0004397; Molecular function: histidine ammonia-lyase activity.
GO:0006548; Biological process: histidine catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00221; Lyase_aromatic; 1;
TIGRFAMs TIGR01225; HutH; 1;
PROSITE PS00488; PAL_HISTIDASE; 1;

Features [?]

From: HUTH_PSEPU (P21310)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     144     144       2,3-didehydroalanine (Ser)     S  
CROSSLNK     143     145       5-imidazolinone (Ala-Gly)     [CSA]-S-G  

Additional information [?]

Size range 495-525 amino acids
Related rules None
Fusion Nter: MF_00372 (hutI); Cter: None


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