HAMAP rule MF_00230
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00230 |
| Accession | MF_00230 |
| Dates | 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 33) |
| Name | CobT |
| Scope(s) |
Bacteria |
| Template(s) | P36562 (COBT_ECOLI); Q05603 (COBT_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_00230 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COBT |
| Protein name | RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Short=NN:DBI PRT; EC=2.4.2.21; AltName: Full=N(1)-alpha-phosphoribosyltransferase; |
| Gene name | Name=cobT; |
Comments
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| FUNCTION | Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). |
| CATALYTIC ACTIVITY | Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + nicotinate + H(+); Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890, ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21; |
| PATHWAY | Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha- ribazole from 5,6-dimethylbenzimidazole: step 1/2. |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the CobT family. |
Keywords
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Gene Ontology
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| GO:0008939; Molecular function:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity |
Cross-references
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Features
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| From: COBT_ECOLI (P36562) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 318 | 318 | /note="Proton acceptor" | |||||||||
Additional information
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| Size range | 334-375 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |