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HAMAP rule MF_00236

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General rule information [?]

Accession MF_00236
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name TatA_E
Template P69428 (TATA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Sec-independent protein translocase protein TatA;
Gene name

Comments [?]

Function Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
case <OC:Pseudomonadota> or <OC:Actinomycetota>
Subunit The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.
Subunit Forms a complex with TatC.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Single-pass membrane protein.
end case
Similarity Belongs to the TatA/E family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0008320; Molecular function: protein transmembrane transporter activity.
GO:0043953; Biological process: protein transport by the Tat complex.
GO:0005886; Cellular component: plasma membrane.
GO:0033281; Cellular component: TAT protein transport complex.

Cross-references [?]

Pfam PF02416; MttA_Hcf106; 1;
NCBIfam TIGR01411; TatAE; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Additional information [?]

Size range 53-105 amino acids
Related rules MF_00903 (TATE supersedes the current rule)
Fusion None
Comments Presence of a second copy called TatE in many Enterobacteriaceae. TatA and TatE are functionally equivalent to each other. TatE may be a cryptic gene duplication of tatA. Profile MF_00236 matches both TatA and TatE.