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HAMAP rule MF_00236

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General rule information [?]

Accession MF_00236
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name TatA_E
Scope
Bacteria
Archaea
Template P69428 (TATA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TATA
Protein name
RecName: Full=Sec-independent protein translocase protein TatA;
Gene name
tatA

Comments [?]

Function Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
case <OC:Pseudomonadota> or <OC:Actinomycetota>
Subunit The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.
else
Subunit Forms a complex with TatC.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Single-pass membrane protein.
end case
Similarity Belongs to the TatA/E family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Transport
Protein transport
Translocation
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008320; Molecular function: protein transmembrane transporter activity.
GO:0043953; Biological process: protein transport by the Tat complex.
GO:0005886; Cellular component: plasma membrane.
GO:0033281; Cellular component: TAT protein transport complex.

Cross-references [?]

Pfam PF02416; MttA_Hcf106; 1;
NCBIfam TIGR01411; TatAE; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Additional information [?]

Size range 53-105 amino acids
Related rules MF_00903 (TATE supersedes the current rule)
Fusion None
Comments Presence of a second copy called TatE in many Enterobacteriaceae. TatA and TatE are functionally equivalent to each other. TatE may be a cryptic gene duplication of tatA. Profile MF_00236 matches both TatA and TatE.


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