HAMAP rule MF_00236
General rule information
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| Accession | MF_00236 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41) |
| Name | TatA_E |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P69428 (TATA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00236 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TATA |
| RecName: Full=Sec-independent protein translocase protein TatA; | |
| Gene name | Name=tatA; |
Comments
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| FUNCTION | Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. |
| case <OC:Pseudomonadota> or <OC:Actinomycetota> | |
| SUBUNIT | The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. |
| else | |
| SUBUNIT | Forms a complex with TatC. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the TatA/E family. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Transport | |
| Protein transport | |
| Translocation | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0008320; Molecular function:protein transmembrane transporter activity |
| GO:0043953; Biological process:protein transport by the Tat complex |
| GO:0005886; Cellular component:plasma membrane |
| GO:0033281; Cellular component:TAT protein transport complex |
Cross-references
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| Pfam | PF02416; MttA_Hcf106; 1; |
| NCBIfam | TIGR01411; TatAE; 1; |
| General | Transmembrane; -; 1; |
Features
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Additional information
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| Size range | 53-105 amino acids |
| Related rules |
MF_00903 |
| Fusion | Nter: None Cter: None |
| Comments | Presence of a second copy called TatE in many Enterobacteriaceae. TatA and TatE are functionally equivalent to each other. TatE may be a cryptic gene duplication of tatA. Profile MF_00236 matches both TatA and TatE. |