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Annotation rule MF_00236 |
General rule information
[?]
Accession |
MF_00236 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 37) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Sec-independent protein translocase protein TatA;
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Function |
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. |
case <OC:Proteobacteria> or <OC:Actinobacteria>
Subunit |
The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. |
else
Subunit |
Forms a complex with TatC. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Single-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Single-pass membrane protein. |
end case
Similarity |
Belongs to the TatA/E family. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0008320; Molecular function: protein transmembrane transporter activity.
GO:0043953; Biological process: protein transport by the Tat complex.
GO:0005887; Cellular component: integral component of plasma membrane.
GO:0033281; Cellular component: TAT protein transport complex.
General |
Transmembrane; -; 1; trigger=yes; |
Additional information
[?]
Size range |
53-105 amino acids |
Related rules |
MF_00903 (TATE supersedes the current rule) |
Fusion |
None |
Comments |
Presence of a second copy called TatE in many Enterobacteriaceae. TatA and TatE are functionally equivalent to each other. TatE may be a cryptic gene duplication of tatA. Profile MF_00236 matches both TatA and TatE. |