HAMAP rule MF_00236
General rule information
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Accession | MF_00236 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 41) |
Name | TatA_E |
Scope | Bacteria
Archaea |
Template | P69428 (TATA_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. |
case <OC:Pseudomonadota> or <OC:Actinomycetota>
Subunit | The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. |
else
Subunit | Forms a complex with TatC. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Single-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Single-pass membrane protein. |
end case
Similarity | Belongs to the TatA/E family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0008320; Molecular function: protein transmembrane transporter activity.
GO:0043953; Biological process: protein transport by the Tat complex.
GO:0005886; Cellular component: plasma membrane.
GO:0033281; Cellular component: TAT protein transport complex.
GO:0043953; Biological process: protein transport by the Tat complex.
GO:0005886; Cellular component: plasma membrane.
GO:0033281; Cellular component: TAT protein transport complex.
Cross-references
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Computed features
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General | Transmembrane; -; 1; trigger=yes; |
Additional information
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Size range | 53-105 amino acids |
Related rules | MF_00903 (TATE supersedes the current rule) |
Fusion | None |
Comments | Presence of a second copy called TatE in many Enterobacteriaceae. TatA and TatE are functionally equivalent to each other. TatE may be a cryptic gene duplication of tatA. Profile MF_00236 matches both TatA and TatE. |