HAMAP rule MF_00236

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00236
Accession	MF_00236
Dates	28-FEB-2005 (Created) 01-JUN-2023 (Last updated, Version 32)
Name	TatA_E
Scope(s)	Bacteria Archaea
Template(s)	P69428; [ Recover all ]
Triggered by	HAMAP; MF_00236 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TATA
Protein name	RecName: Full=Sec-independent protein translocase protein TatA;
Gene name	Name=tatA;

Comments [?]

FUNCTION	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
case <OC:Pseudomonadota> or <OC:Actinomycetota>
SUBUNIT	The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.
else
SUBUNIT	Forms a complex with TatC.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Single-pass membrane protein.
end case
SIMILARITY	Belongs to the TatA/E family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Transport
Protein transport
Translocation
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008320; Molecular function:protein transmembrane transporter activity

GO:0043953; Biological process:protein transport by the Tat complex

GO:0005886; Cellular component:plasma membrane

GO:0033281; Cellular component:TAT protein transport complex

Cross-references [?]

Features [?]

Additional information [?]

Size range	53-105 amino acids
Related rules	MF_00903
Fusion	Nter: None Cter: None
Comments	Presence of a second copy called TatE in many Enterobacteriaceae. TatA and TatE are functionally equivalent to each other. TatE may be a cryptic gene duplication of tatA. Profile MF_00236 matches both TatA and TatE.