HAMAP rule MF_00238

General rule information [?]

Accession	MF_00238
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 35)

Name	Cytidyl_kinase_type1

Scope

Bacteria; except Cyanobacteriota

Templates

P0A6I0 (KCY_ECOLI); P38493 (KCY_BACSU); P9WPA9 (KCY_MYCTU): [Recover all]

Triggered by

HAMAP; MF_00238 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

KCY

Protein name

RecName:		Full=Cytidylate kinase;
		Short=CK;
		EC 2.7.4.25;
AltName:		Full=Cytidine monophosphate kinase;
		Short=CMP kinase;

Gene name

cmk

Comments [?]

Catalytic activity	RHEA:11600: ATP + CMP = ADP + CDP EC 2.7.4.25
	RHEA:25094: ATP + dCMP = ADP + dCDP EC 2.7.4.25
Subcellular location	Cytoplasm.
Similarity	Belongs to the cytidylate kinase family. Type 1 subfamily.

Keywords [?]

Cytoplasm
Transferase
Kinase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004127; Molecular function: cytidylate kinase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02224; Cytidylate_kin; 1;
NCBIfam	TIGR00017; Cmk; 1;

Features [?]

From: KCY_ECOLI (P0A6I0)

Key From To Description Tag Condition FTGroup

BINDING 12 20 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-x(2)-[GSA]-x-G-K-[GST]-[STAV]

Additional information [?]

Size range	206-235 amino acids
Related rules	MF_00239 (KCY); MF_01349 (PANCY supersedes the current rule)
Fusion	None
Comments	In Cyanobacteriota this protein is fused N-terminally to pantoate-- beta-alanine ligase (see MF_01349). BORBU and BORGP also have a subfamily 2 enzyme.

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