HAMAP rule MF_00238
General rule information
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| Accession | MF_00238 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 35) |
| Name | Cytidyl_kinase_type1 |
| Scope(s) |
Bacteria |
| Template(s) | P0A6I0 (KCY_ECOLI); P38493 (KCY_BACSU); P9WPA9 (KCY_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00238 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KCY |
| Protein name | RecName: Full=Cytidylate kinase; Short=CK; EC=2.7.4.25; AltName: Full=Cytidine monophosphate kinase; Short=CMP kinase; |
| Gene name | Name=cmk; |
Comments
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| CATALYTIC ACTIVITY | Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600, ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.4.25; |
| CATALYTIC ACTIVITY | Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094, ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593, ChEBI:CHEBI:456216; EC=2.7.4.25; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the cytidylate kinase family. Type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0004127; Molecular function:cytidylate kinase activity |
| GO:0006220; Biological process:pyrimidine nucleotide metabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: KCY_ECOLI (P0A6I0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 20 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x(2)-[GSA]-x-G-K-[GST]-[STAV] | ||||||||
Additional information
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| Size range | 206-235 amino acids |
| Related rules |
MF_00239 MF_01349 |
| Fusion | Nter: None Cter: None |
| Comments | In Cyanobacteriota this protein is fused N-terminally to pantoate-- beta-alanine ligase (see MF_01349). BORBU and BORGP also have a subfamily 2 enzyme. |