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| Annotation rule MF_00240 |
General rule information
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| Accession | MF_00240 |
| Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 19) |
| Name | LolA |
| Scope | Bacteria; Proteobacteria |
| Template | P61316 (LOLA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). |
| Subunit | Monomer. |
| Subcellular location | Periplasm. |
| Similarity | Belongs to the LolA family. |
Keywords
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Gene Ontology
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GO:0044874; Biological process: lipoprotein localization to outer membrane.
GO:0042597; Cellular component: periplasmic space.
GO:0042597; Cellular component: periplasmic space.
Cross-references
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Computed features
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| General | Signal; -; 1; trigger=yes; |
Additional information
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| Size range | 169-215 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | The epsilon proteobacteria possess lolA but apparently they do not have lolB. Further characterization is needed to assess to which protein the outer membrane lipoproteins are translocated (the same applies to the animal symbionts Candidatus Blochmannia floridanus and Wigglesworthia glossinidia brevipalpis). |