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HAMAP rule MF_00240

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General rule information [?]

Accession MF_00240
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 22)
Name LolA
Scope(s) Bacteria
Template(s) P61316 (LOLA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00240 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LOLA
Protein name RecName: Full=Outer-membrane lipoprotein carrier protein;
case <Feature:Signal>
Protein name + Flags: Precursor;
end case
Gene name Name=lolA;

Comments [?]

FUNCTIONParticipates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
SIMILARITYBelongs to the LolA family.

Keywords [?]

Protein transport
case <Feature:Signal>
end case

Gene Ontology [?]

GO:0044874; Biological process:lipoprotein localization to outer membrane
GO:0042597; Cellular component:periplasmic space

Cross-references [?]

Pfam PF03548; LolA; 1;
NCBIfam TIGR00547; LolA; 1;
General Signal; -; 1;

Features [?]

Additional information [?]

Size range 169-215 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The epsilon proteobacteria possess lolA but apparently they do not have lolB. Further characterization is needed to assess to which protein the outer membrane lipoproteins are translocated (the same applies to the animal symbionts Candidatus Blochmannia floridanus and Wigglesworthia glossinidia brevipalpis).

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