HAMAP rule MF_00240
General rule information
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| Accession | MF_00240 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 22) |
| Name | LolA |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P61316 (LOLA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00240 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LOLA |
| Protein name | RecName: Full=Outer-membrane lipoprotein carrier protein; |
| case <Feature:Signal> | |
| Protein name | + Flags: Precursor; |
| end case | |
| Gene name | Name=lolA; |
Comments
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| FUNCTION | Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Periplasm. |
| SIMILARITY | Belongs to the LolA family. |
Keywords
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| Chaperone | |
| Transport | |
| Protein transport | |
| Periplasm | |
| case <Feature:Signal> | |
| Signal | |
| end case | |
Gene Ontology
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| GO:0044874; Biological process:lipoprotein localization to outer membrane |
| GO:0042597; Cellular component:periplasmic space |
Cross-references
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Features
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Additional information
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| Size range | 169-215 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The epsilon proteobacteria possess lolA but apparently they do not have lolB. Further characterization is needed to assess to which protein the outer membrane lipoproteins are translocated (the same applies to the animal symbionts Candidatus Blochmannia floridanus and Wigglesworthia glossinidia brevipalpis). |