HAMAP rule MF_00243
General rule information
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| Accession | MF_00243 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 31) |
| Name | NMN_adenylyltr |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q57961 (NADM_METJA); O26253 (NADM_METTH); [ Recover all ] |
| Triggered by |
HAMAP; MF_00243 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NADM |
| Protein name | RecName: Full=Nicotinamide-nucleotide adenylyltransferase; EC=2.7.7.1; AltName: Full=NAD(+) diphosphorylase; AltName: Full=NAD(+) pyrophosphorylase; AltName: Full=NMN adenylyltransferase; |
Comments
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| CATALYTIC ACTIVITY | Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1; |
| PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the archaeal NMN adenylyltransferase family. |
Keywords
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| ATP-binding |
| Cytoplasm |
| NAD |
| Nucleotide-binding |
| Nucleotidyltransferase |
| Pyridine nucleotide biosynthesis |
| Transferase |
Gene Ontology
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| GO:0000309; Molecular function:nicotinamide-nucleotide adenylyltransferase activity |
| GO:0009435; Biological process:NAD biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01467; CTP_transf_2; 1; |
| NCBIfam | TIGR01527; Arch_NMN_Atrans; 1; |
| NCBIfam | TIGR00125; Cyt_tran_rel; 1; |
Features
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Additional information
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| Size range | 168-188 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <Nudix> |
| Comments | There are closely related homolog of nadD in ARCFU (AF1488) and AERPE (APE1986). Nudix-like C-terminal domain in SYNY3. |