HAMAP rule MF_00244

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00244
Accession	MF_00244
Dates	28-FEB-2005 (Created) 12-JUN-2025 (Last updated, Version 23)
Name	NaMN_adenylyltr
Scope(s)	Bacteria
Template(s)	P54455; P0A752; [ Recover all ]
Triggered by	HAMAP; MF_00244 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NADD
Protein name	RecName: Full=Probable nicotinate-nucleotide adenylyltransferase; EC=2.7.7.18; AltName: Full=Deamido-NAD(+) diphosphorylase; AltName: Full=Deamido-NAD(+) pyrophosphorylase; AltName: Full=Nicotinate mononucleotide adenylyltransferase; Short=NaMN adenylyltransferase;
Gene name	Name=nadD;

Comments [?]

FUNCTION	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
CATALYTIC ACTIVITY	Reaction=nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate; Xref=Rhea:RHEA:22860, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502, ChEBI:CHEBI:58437; EC=2.7.7.18;
PATHWAY	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.
SIMILARITY	Belongs to the NadD family.

Keywords [?]

Gene Ontology [?]

GO:0004515; Molecular function:nicotinate-nucleotide adenylyltransferase activity

GO:0009435; Biological process:NAD+ biosynthetic process

Cross-references [?]

Features [?]

Additional information [?]

Size range	168-222 amino acids
Related rules	None
Fusion	Nter: None Cter: <Unknown>
Comments	Distant relative in MYCGE (MG240) and MYCPN (MPN336).