HAMAP rule MF_00249

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00249
Accession	MF_00249
Dates	28-FEB-2005 (Created) 01-JUN-2023 (Last updated, Version 25)
Name	HslU
Scope(s)	Bacteria
Template(s)	P0A6H5; P43773; P39778; Q9WYZ2; [ Recover all ]
Triggered by	HAMAP; MF_00249 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HSLU
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Protein name	RecName: Full=ATP-dependent protease ATPase subunit HslU; AltName: Full=Heat shock protein HslU; AltName: Full=Unfoldase HslU;
end case
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
Protein name	RecName: Full=ATP-dependent protease ATPase subunit HslU; AltName: Full=Unfoldase HslU;
end case
Gene name	Name=hslU;

Comments [?]

FUNCTION	ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
SUBUNIT	A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
SUBCELLULAR LOCATION	Cytoplasm.
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
INDUCTION	By heat shock.
end case
SIMILARITY	Belongs to the ClpX chaperone family. HslU subfamily.

Keywords [?]

Cytoplasm
ATP-binding
Chaperone
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Stress response
end case
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0036402; Molecular function:proteasome-activating activity

GO:0043335; Biological process:protein unfolding

GO:0005737; Cellular component:cytoplasm

GO:0009376; Cellular component:HslUV protease complex

Cross-references [?]

Features [?]

From: HSLU_ECOLI (P0A6H5)

Key

From

Description

Tag

Condition

FTGroup

BINDING