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HAMAP rule MF_00259

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General rule information [?]

Accession MF_00259
Dates 1-JUN-2001 (Created)
14-SEP-2023 (Last updated, Version 26)
Name GcvT
Scope(s) Bacteria
Template(s) P27248 (GCST_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00259 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GCST
case <OC:Bacteria>
Protein name RecName: Full=Aminomethyltransferase;
AltName: Full=Glycine cleavage system T protein;
end case
case <OC:Archaea>
Protein name RecName: Full=Probable aminomethyltransferase;
AltName: Full=Glycine cleavage system T protein;
end case
Gene name Name=gcvT;

Comments [?]

FUNCTIONThe glycine cleavage system catalyzes the degradation of glycine.
CATALYTIC ACTIVITY Reaction=(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)- aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-methylene- 5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA- COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453, ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=;
SUBUNITThe glycine cleavage system is composed of four proteins: P, T, L and H.
SIMILARITYBelongs to the GcvT family.

Keywords [?]

Gene Ontology [?]

GO:0004047; Molecular function:aminomethyltransferase activity
GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system

Cross-references [?]

Pfam PF01571; GCV_T; 1;
NCBIfam TIGR00528; GcvT; 1;

Features [?]

Additional information [?]

Size range 349-401 amino acids
Related rules None
Fusion Nter: None Cter: None

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