HAMAP rule MF_00259

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00259
Accession	MF_00259
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 17)
Name	GcvT
Scope(s)	Bacteria Archaea
Template(s)	P27248; [ Recover all ]
Triggered by	HAMAP; MF_00259 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GCST
case <OC:Bacteria>
Protein name	RecName: Full=Aminomethyltransferase; EC=2.1.2.10; AltName: Full=Glycine cleavage system T protein;
end case
case <OC:Archaea>
Protein name	RecName: Full=Probable aminomethyltransferase; EC=2.1.2.10; AltName: Full=Glycine cleavage system T protein;
end case
Gene name	Name=gcvT;

Comments [?]

FUNCTION	The glycine cleavage system catalyzes the degradation of glycine.
CATALYTIC ACTIVITY	Reaction=N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl- [protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA- COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453, ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10;
SUBUNIT	The glycine cleavage system is composed of four proteins: P, T, L and H.
SIMILARITY	Belongs to the GcvT family.

Keywords [?]

Gene Ontology [?]

GO:0004047; Molecular function:aminomethyltransferase activity

GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system

Cross-references [?]

Pfam	PF01571; GCV_T; 1;
NCBIfam	TIGR00528; GcvT; 1;

Features [?]

Additional information [?]