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| Annotation rule MF_00272 |
General rule information
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| Accession | MF_00272 |
| Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 34) |
| Name | GcvH |
| Scope | Bacteria
Archaea |
| Templates | P0A6T9 (GCSH_ECOLI); O32174 (GCSH_BACSU): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Bacteria> and not <OC:Bacillales>
| Protein name |
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end case
case <OC:Bacillales>
| Protein name |
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end case
case <OC:Archaea>
| Protein name |
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end case
| Gene name |
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Comments
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| Function | The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. |
case <OC:Bacillales>
| Function | Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate. |
end case
| Cofactor | (R)-lipoate Note: Binds 1 lipoyl cofactor covalently. |
| Subunit | The glycine cleavage system is composed of four proteins: P, T, L and H. |
| Similarity | Belongs to the GcvH family. |
Keywords
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Gene Ontology
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GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.
case <OC:Bacillales>
GO:0009249; Biological process: protein lipoylation.
end case
Cross-references
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| Pfam | PF01597; GCV_H; 1; |
| TIGRFAMs | TIGR00527; GcvH; 1; |
| PROSITE | PS00189; LIPOYL; 1; |
| PS50968; BIOTINYL_LIPOYL; 1; trigger=PRU01066; |
Features
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| From: GCSH_ECOLI (P0A6T9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 65 | 65 | N6-lipoyllysine | K | ||||||||
Additional information
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| Size range | 115-171 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | The role of GcvH as an octanoyl/lipoyl carrier protein intermediate during protein lipoylation has been shown in Bacillus subtilis (PubMed=21338421, AC:O32174). There are five potential gcvH in AQUAE. |