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Annotation rule MF_00272 |
General rule information
[?]
Accession |
MF_00272 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 34) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Bacteria> and not <OC:Bacillales>
Protein name |
RecName:
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Full=Glycine cleavage system H protein;
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end case
case <OC:Bacillales>
Protein name |
RecName:
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Full=Glycine cleavage system H protein;
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AltName:
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Full=Octanoyl/lipoyl carrier protein;
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end case
case <OC:Archaea>
Protein name |
RecName:
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Full=Probable glycine cleavage system H protein;
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end case
Function |
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. |
case <OC:Bacillales>
Function |
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate. |
end case
Cofactor |
(R)-lipoate Note: Binds 1 lipoyl cofactor covalently. |
Subunit |
The glycine cleavage system is composed of four proteins: P, T, L and H. |
Similarity |
Belongs to the GcvH family. |
GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.
case <OC:Bacillales>
GO:0009249; Biological process: protein lipoylation.
end case
From: GCSH_ECOLI (P0A6T9) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOD_RES
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65
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65
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N6-lipoyllysine
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K
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Additional information
[?]
Size range |
115-171 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
The role of GcvH as an octanoyl/lipoyl carrier protein intermediate during protein lipoylation has been shown in Bacillus subtilis (PubMed=21338421, AC:O32174). There are five potential gcvH in AQUAE. |