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Annotation rule MF_00289
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General rule information [?]

Accession MF_00289
Dates 1-JUN-2001 (Created)
16-JUN-2020 (Last updated, Version 37)
Name Proteasome_A
Scope
Archaea
Bacteria; Actinobacteria
Templates Q60177 (PSA_METJA); P25156 (PSA_THEAC); P9WHU1 (PSA_MYCTU); Q9V2V6 (PSA1_HALVD); Q9V2V5 (PSA2_HALVD); Q53080 (PSA1_RHOER); Q53084 (PSA2_RHOER); O29760 (PSA_ARCFU): [Recover all]
case <OC:Bacteria>
end case

case <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PSA
case <OC:Bacteria>
Protein name
RecName: Full=Proteasome subunit alpha;
AltName: Full=20S proteasome alpha subunit;
AltName: Full=Proteasome core protein PrcA;
Gene name
prcA
end case
case <OC:Archaea>
Protein name
RecName: Full=Proteasome subunit alpha;
AltName: Full=20S proteasome alpha subunit;
AltName: Full=Proteasome core protein PsmA;
Gene name
psmA
end case

Comments [?]

Function Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
case <OC:Bacteria>
Activity regulation The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
Pathway Protein degradation; proteasomal Pup-dependent pathway.
Subunit The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
end case
case <OC:Archaea>
Activity regulation The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
Subunit The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the peptidase T1A family.

Keywords [?]


Gene Ontology [?]

GO:0010498; Biological process: proteasomal protein catabolic process.
case <OC:Bacteria>
GO:0019941; Biological process: modification-dependent protein catabolic process.
end case
GO:0005737; Cellular component: cytoplasm.
GO:0019773; Cellular component: proteasome core complex, alpha-subunit complex.

Cross-references [?]

PROSITE PS00388; PROTEASOME_ALPHA_1; 1;
PS51475; PROTEASOME_ALPHA_2; 1;
Pfam PF00227; Proteasome; 1;
PF10584; Proteasome_A_N; 1;
TIGRFAMs TIGR03691; 20S_bact_alpha; 1;
TIGR03633; Arc_protsome_A; 1;

Additional information [?]

case <OC:Bacteria>
Size range 230-292 amino acids
end case
case <OC:Archaea>
Size range 233-261 amino acids
end case
Related rules None
Fusion None
Comments Subunit beta of the proteasome core is in MF_02113.