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HAMAP rule MF_00289

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General rule information [?]

Accession MF_00289
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name Proteasome_A
Scope(s) Archaea
Bacteria
Actinomycetota
Template(s) Q60177 (PSA_METJA); P25156 (PSA_THEAC); P9WHU1 (PSA_MYCTU); Q9V2V6 (PSA1_HALVD); Q9V2V5 (PSA2_HALVD); Q53080 (PSA1_RHOER); Q53084 (PSA2_RHOER); O29760 (PSA_ARCFU); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00289_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_00289_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PSA
case <OC:Bacteria>
Protein name RecName: Full=Proteasome subunit alpha;
AltName: Full=20S proteasome alpha subunit;
AltName: Full=Proteasome core protein PrcA;
Gene name Name=prcA;
end case
case <OC:Archaea>
Protein name RecName: Full=Proteasome subunit alpha;
AltName: Full=20S proteasome alpha subunit;
AltName: Full=Proteasome core protein PsmA;
Gene name Name=psmA;
end case

Comments [?]

FUNCTIONComponent of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
case <OC:Bacteria>
ACTIVITY REGULATIONThe formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
PATHWAYProtein degradation; proteasomal Pup-dependent pathway.
SUBUNITThe 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
end case
case <OC:Archaea>
ACTIVITY REGULATIONThe formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close- gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
SUBUNITThe 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the peptidase T1A family.

Keywords [?]


Gene Ontology [?]

GO:0010498; Biological process:proteasomal protein catabolic process
case <OCellular component:Bacteria>
GO:0019941; Biological process:modification-dependent protein catabolic process
end case
GO:0005737; Cellular component:cytoplasm
GO:0019773; Cellular component:proteasome core complex, alpha-subunit complex

Cross-references [?]

PROSITE PS00388; PROTEASOME_ALPHA_1; 1;
PROSITE PS51475; PROTEASOME_ALPHA_2; 1;
Pfam PF00227; Proteasome; 1;
Pfam PF10584; Proteasome_A_N; 1;
NCBIfam TIGR03691; 20S_bact_alpha; 1;
NCBIfam TIGR03633; Arc_protsome_A; 1;

Features [?]


Additional information [?]

Size range 233-261 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Subunit beta of the proteasome core is in MF_02113.



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