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| Annotation rule MF_00289 |
General rule information
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| Accession | MF_00289 |
| Dates | 1-JUN-2001 (Created) 16-JUN-2020 (Last updated, Version 37) |
| Name | Proteasome_A |
| Scope | Archaea
Bacteria; Actinobacteria |
| Templates | Q60177 (PSA_METJA); P25156 (PSA_THEAC); P9WHU1 (PSA_MYCTU); Q9V2V6 (PSA1_HALVD); Q9V2V5 (PSA2_HALVD); Q53080 (PSA1_RHOER); Q53084 (PSA2_RHOER); O29760 (PSA_ARCFU): [Recover all] |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Bacteria>
| Protein name |
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| Gene name |
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end case
case <OC:Archaea>
| Protein name |
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| Gene name |
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end case
Comments
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| Function | Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. |
case <OC:Bacteria>
| Activity regulation | The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. |
| Pathway | Protein degradation; proteasomal Pup-dependent pathway. |
| Subunit | The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC. |
end case
case <OC:Archaea>
| Activity regulation | The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. |
| Subunit | The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN. |
end case
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the peptidase T1A family. |
Keywords
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Gene Ontology
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GO:0010498; Biological process: proteasomal protein catabolic process.
case <OC:Bacteria>
GO:0019941; Biological process: modification-dependent protein catabolic process.
end case
GO:0005737; Cellular component: cytoplasm.
GO:0019773; Cellular component: proteasome core complex, alpha-subunit complex.
GO:0019773; Cellular component: proteasome core complex, alpha-subunit complex.
Cross-references
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| PROSITE | PS00388; PROTEASOME_ALPHA_1; 1; |
| PS51475; PROTEASOME_ALPHA_2; 1; | |
| Pfam | PF00227; Proteasome; 1; |
| PF10584; Proteasome_A_N; 1; | |
| TIGRFAMs | TIGR03691; 20S_bact_alpha; 1; |
| TIGR03633; Arc_protsome_A; 1; |
Additional information
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case <OC:Bacteria>
| Size range | 230-292 amino acids |
end case
case <OC:Archaea>
| Size range | 233-261 amino acids |
end case
| Related rules | None |
| Fusion | None |
| Comments | Subunit beta of the proteasome core is in MF_02113. |