HAMAP rule MF_00289
General rule information
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Accession | MF_00289 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39) |
Name | Proteasome_A |
Scope(s) |
Archaea Bacteria Actinomycetota |
Template(s) | Q60177 (PSA_METJA); P25156 (PSA_THEAC); P9WHU1 (PSA_MYCTU); Q9V2V6 (PSA1_HALVD); Q9V2V5 (PSA2_HALVD); Q53080 (PSA1_RHOER); Q53084 (PSA2_RHOER); O29760 (PSA_ARCFU); [ Recover all ] |
Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_00289_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_00289_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | PSA |
case <OC:Bacteria> | |
Protein name | RecName: Full=Proteasome subunit alpha; AltName: Full=20S proteasome alpha subunit; AltName: Full=Proteasome core protein PrcA; |
Gene name | Name=prcA; |
end case | |
case <OC:Archaea> | |
Protein name | RecName: Full=Proteasome subunit alpha; AltName: Full=20S proteasome alpha subunit; AltName: Full=Proteasome core protein PsmA; |
Gene name | Name=psmA; |
end case |
Comments
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FUNCTION | Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. |
case <OC:Bacteria> | |
ACTIVITY REGULATION | The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. |
PATHWAY | Protein degradation; proteasomal Pup-dependent pathway. |
SUBUNIT | The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC. |
end case | |
case <OC:Archaea> | |
ACTIVITY REGULATION | The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close- gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. |
SUBUNIT | The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the peptidase T1A family. |
Keywords
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Gene Ontology
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GO:0010498; Biological process:proteasomal protein catabolic process | |
case <OCellular component:Bacteria> | |
GO:0019941; Biological process:modification-dependent protein catabolic process | |
end case | |
GO:0005737; Cellular component:cytoplasm | |
GO:0019773; Cellular component:proteasome core complex, alpha-subunit complex |
Cross-references
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PROSITE | PS00388; PROTEASOME_ALPHA_1; 1; |
PROSITE | PS51475; PROTEASOME_ALPHA_2; 1; |
Pfam | PF00227; Proteasome; 1; |
Pfam | PF10584; Proteasome_A_N; 1; |
NCBIfam | TIGR03691; 20S_bact_alpha; 1; |
NCBIfam | TIGR03633; Arc_protsome_A; 1; |
Features
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Additional information
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Size range | 233-261 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Subunit beta of the proteasome core is in MF_02113. |