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HAMAP rule MF_00298

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General rule information [?]

Accession MF_00298
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 25)
Name Nudix_RppH
Templates P0A776 (RPPH_ECOLI); Q9ZDT9 (RPPH_RICPR): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=RNA pyrophosphohydrolase;
EC 3.6.1.-;
AltName: Full=(Di)nucleoside polyphosphate hydrolase;
Gene name
rppH, nudH

Comments [?]

Function Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
Cofactor a divalent metal cation
Similarity Belongs to the Nudix hydrolase family. RppH subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.

Cross-references [?]

Pfam PF00293; NUDIX; 1;
PROSITE PS51462; NUDIX; 1; trigger=PRU00794;
PS00893; NUDIX_BOX; 1;

Features [?]

From: RPPH_ECOLI (P0A776)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     38     59       Nudix box        

Additional information [?]

Size range 155-238 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: None
Comments Unknown N-terminal domain in COXBU