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HAMAP rule MF_00317

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General rule information [?]

Accession MF_00317
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 19)
Name DNApol_clamp_arch
Scope(s) Archaea
Template(s) O73947 (PCNA_PYRFU); P57765 (PCNA3_SACS2); P57766 (PCNA1_SACS2); Q97Z84 (PCNA2_SACS2); Q975N2 (PCNA1_SULTO); Q975M2 (PCNA2_SULTO); Q973F5 (PCNA3_SULTO); [ Recover all ]
Triggered by HAMAP; MF_00317 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PCNA
Protein name RecName: Full=DNA polymerase sliding clamp;
AltName: Full=Proliferating cell nuclear antigen homolog;
Gene name Name=pcn;

Comments [?]

FUNCTIONSliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
SUBUNITHomotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
SIMILARITYBelongs to the PCNA family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0030337; Molecular function:DNA polymerase processivity factor activity
GO:0006275; Biological process:regulation of DNA replication

Cross-references [?]

Pfam PF02747; PCNA_C; 1;
Pfam PF00705; PCNA_N; 1;
NCBIfam TIGR00590; Pcna; 1;
PROSITE PS01251; PCNA_1; 1;
PROSITE PS00293; PCNA_2; 1;

Features [?]

Additional information [?]

Size range 244-256 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Some Archaea have up to 3 copies.

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