HAMAP rule MF_00325

Accession	MF_00325
Dates	1-JUN-2001 (Created) 3-MAY-2022 (Last updated, Version 25)

Name	DNApol_II_A_arch

Scope

Archaea

Template

P81412 (DP2S_PYRFU)

Triggered by

HAMAP; MF_00325 (Get profile general information and statistics)

Identifier

DP2S

Protein name

RecName: Full=DNA polymerase II small subunit; Short=Pol II; EC 2.7.7.7; AltName: Full=Exodeoxyribonuclease small subunit; EC 3.1.11.1;

Gene name

polB

Function	Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Catalytic activity	RHEA:22508: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) EC 2.7.7.7
	Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.1;
Subunit	Heterodimer of a large subunit and a small subunit.
Similarity	Belongs to the DNA polymerase delta/II small subunit family.

Transferase
Nucleotidyltransferase
DNA-directed DNA polymerase
DNA replication
Hydrolase
Nuclease
Exonuclease
DNA-binding
Multifunctional enzyme

GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000738; Biological process: DNA catabolic process, exonucleolytic.
GO:0006261; Biological process: DNA-templated DNA replication.

Pfam	PF01336; tRNA_anti; 1;

Size range	370-735 amino acids
Related rules	None
Fusion	None

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