HAMAP rule MF_00325
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00325 |
| Accession | MF_00325 |
| Dates | 28-FEB-2005 (Created)
02-SEP-2024 (Last updated, Version 18) |
| Name | DNApol_II_A_arch |
| Scope(s) |
Archaea |
| Template(s) | P81412; [ Recover all ] |
| Triggered by |
HAMAP; MF_00325 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DP2S |
| Protein name | RecName: Full=DNA polymerase II small subunit; Short=Pol II; EC=2.7.7.7; AltName: Full=Exodeoxyribonuclease small subunit; EC=3.1.11.1; |
| Gene name | Name=polB; |
Comments
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| FUNCTION | Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. |
| CATALYTIC ACTIVITY | Reaction=DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate; Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; |
| CATALYTIC ACTIVITY | Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.1; |
| SUBUNIT | Heterodimer of a large subunit and a small subunit. |
| SIMILARITY | Belongs to the DNA polymerase delta/II small subunit family. |
Keywords
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| Transferase |
| Nucleotidyltransferase |
| DNA-directed DNA polymerase |
| DNA replication |
| Hydrolase |
| Nuclease |
| Exonuclease |
| DNA-binding |
| Multifunctional enzyme |
Gene Ontology
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| GO:0008408; Molecular function:3'-5' exonuclease activity |
| GO:0003677; Molecular function:DNA binding |
| GO:0003887; Molecular function:DNA-directed DNA polymerase activity |
| GO:0006308; Biological process:DNA catabolic process |
| GO:0006261; Biological process:DNA-templated DNA replication |
Cross-references
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| Pfam | PF01336; tRNA_anti; 1; |
Features
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Additional information
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| Size range | 370-735 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |