HAMAP rule MF_00325
General rule information
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Accession | MF_00325 |
Dates | 1-JUN-2001 (Created) 3-MAY-2022 (Last updated, Version 25) |
Name | DNApol_II_A_arch |
Scope | Archaea |
Template | P81412 (DP2S_PYRFU) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. |
Catalytic activity | RHEA:22508: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
EC 2.7.7.7 |
Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.1; | |
Subunit | Heterodimer of a large subunit and a small subunit. |
Similarity | Belongs to the DNA polymerase delta/II small subunit family. |
Keywords
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Transferase
Nucleotidyltransferase
DNA-directed DNA polymerase
DNA replication
Hydrolase
Nuclease
Exonuclease
DNA-binding
Multifunctional enzyme
Nucleotidyltransferase
DNA-directed DNA polymerase
DNA replication
Hydrolase
Nuclease
Exonuclease
DNA-binding
Multifunctional enzyme
Gene Ontology
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GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000738; Biological process: DNA catabolic process, exonucleolytic.
GO:0006261; Biological process: DNA-templated DNA replication.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000738; Biological process: DNA catabolic process, exonucleolytic.
GO:0006261; Biological process: DNA-templated DNA replication.
Cross-references
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Pfam | PF01336; tRNA_anti; 1; |
Additional information
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Size range | 370-735 amino acids |
Related rules | None |
Fusion | None |