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Annotation rule MF_00333
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General rule information [?]

Accession MF_00333
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 41)
Name Coprogen_oxidas
Scope
Bacteria
Templates P36553 (HEM6_ECOLI); P72848 (HEM6_SYNY3): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HEM6
Protein name
RecName: Full=Oxygen-dependent coproporphyrinogen-III oxidase;
Short=CPO;
Short=Coprogen oxidase;
Short=Coproporphyrinogenase;
EC 1.3.3.3;
Gene name
hemF

Comments [?]

case <OC:Cyanobacteria>
Function Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
else
Function Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
end case
Catalytic activity RHEA:18257: coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX
EC 1.3.3.3
case <OC:Escherichia>
Cofactor Mn(2+)
else
Cofactor a divalent metal cation
end case
Pathway Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the aerobic coproporphyrinogen-III oxidase family.

Keywords [?]

case <OC:Cyanobacteria>
Chlorophyll biosynthesis
end case
Cytoplasm
Heme biosynthesis
case <OC:Escherichia>
Manganese
end case
Metal-binding
Oxidoreductase
Porphyrin biosynthesis

Gene Ontology [?]

GO:0004109; Molecular function: coproporphyrinogen oxidase activity.
case <OC:Escherichia>
GO:0030145; Molecular function: manganese ion binding.
end case
GO:0042803; Molecular function: protein homodimerization activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0006783; Biological process: heme biosynthetic process.
case <OC:Cyanobacteria>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01218; Coprogen_oxidas; 1;
PRINTS PR00073; COPRGNOXDASE; 1;
PROSITE PS01021; COPROGEN_OXIDASE; 1;

Features [?]

From: HEM6_ECOLI (P36553)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     108     110       Substrate binding     N-x-R  
REGION     240     275       Important for dimerization        
REGION     258     260       Substrate binding     G-x-[NR]  
ACT_SITE     106     106       Proton donor     H  
case <OC:Escherichia>
METAL     96     96       Manganese     H  
METAL     106     106       Manganese     H  
METAL     145     145       Manganese     H  
METAL     175     175       Manganese     H  
else
METAL     96     96       Divalent metal cation     H  
METAL     106     106       Divalent metal cation     H  
METAL     145     145       Divalent metal cation     H  
METAL     175     175       Divalent metal cation     H  
end case
BINDING     92     92       Substrate     S  
SITE     175     175       Important for dimerization     H  

Additional information [?]

Size range 279-363 amino acids
Related rules None
Fusion None


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