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Annotation rule MF_00333 |
General rule information
[?]
Accession |
MF_00333 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 41) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Oxygen-dependent coproporphyrinogen-III oxidase;
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Short=CPO;
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Short=Coprogen oxidase;
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Short=Coproporphyrinogenase;
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EC 1.3.3.3;
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case <OC:Cyanobacteria>
Function |
Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. |
else
Function |
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. |
end case
Catalytic activity |
RHEA:18257: coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX
EC 1.3.3.3
|
case <OC:Escherichia>
else
end case
Pathway |
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. |
Subunit |
Homodimer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the aerobic coproporphyrinogen-III oxidase family. |
case <OC:Cyanobacteria>
end case
case <OC:Escherichia>
end case
GO:0004109; Molecular function: coproporphyrinogen oxidase activity.
case <OC:Escherichia>
GO:0030145; Molecular function: manganese ion binding.
end case
GO:0042803; Molecular function: protein homodimerization activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0006783; Biological process: heme biosynthetic process.
case <OC:Cyanobacteria>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case
From: HEM6_ECOLI (P36553) |
Key
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From
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To
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Description
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Tag
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|
Condition
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FTGroup
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REGION
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108
|
|
110
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Substrate binding
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|
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N-x-R
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REGION
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240
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275
|
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Important for dimerization
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|
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|
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REGION
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258
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260
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Substrate binding
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|
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G-x-[NR]
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ACT_SITE
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106
|
|
106
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Proton donor
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|
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H
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case <OC:Escherichia>
METAL
|
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96
|
|
96
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Manganese
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H
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|
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METAL
|
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106
|
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106
|
|
Manganese
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|
|
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H
|
|
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METAL
|
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145
|
|
145
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Manganese
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|
|
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H
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|
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METAL
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175
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175
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Manganese
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H
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else
METAL
|
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96
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96
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Divalent metal cation
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H
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METAL
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106
|
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106
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Divalent metal cation
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|
|
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H
|
|
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METAL
|
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145
|
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145
|
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Divalent metal cation
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|
|
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H
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|
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METAL
|
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175
|
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175
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Divalent metal cation
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H
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end case
BINDING
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92
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92
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Substrate
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S
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SITE
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175
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175
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Important for dimerization
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H
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Additional information
[?]
Size range |
279-363 amino acids |
Related rules |
None |
Fusion |
None |