HAMAP rule MF_00336
General rule information
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Accession | MF_00336 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 43) |
Name | BioD |
Scope | Bacteria
Archaea |
Templates | P13000 (BIOD1_ECOLI); P22818 (BIOD_LYSSH); P9WPQ5 (BIOD_MYCTU); O24872 (BIOD_HELPY): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. |
Catalytic activity | RHEA:15805: (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate
EC 6.3.3.3 |
Cofactor | Mg(2+) |
Pathway | Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the dethiobiotin synthetase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0004141; Molecular function: dethiobiotin synthase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0009102; Biological process: biotin biosynthetic process.
GO:0004141; Molecular function: dethiobiotin synthase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0009102; Biological process: biotin biosynthetic process.
Cross-references
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NCBIfam | TIGR00347; BioD; 1; |
PIRSF | PIRSF006755; DTB_synth; 1; |
Features
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From: BIOD1_ECOLI (P13000) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 13 | 18 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [EDNSG]-[VAILSC]-G-K-[TS]-[VLTIYFH] | ||||||||
BINDING | 116 | 119 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | E-x-x-G | ||||||||
BINDING | 176 | 177 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [NSMVILG]-[DEHRQTNCSMK] | ||||||||
BINDING | 205 | 207 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [PA]-x-[LIVSTG] | ||||||||
ACT_SITE | 38 | 38 | K | |||||||||
BINDING | 17 | 17 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | [TS] | ||||||||
BINDING | 55 | 55 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | [DNCRHK] | ||||||||
BINDING | 116 | 116 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | ||||||||
BINDING | 42 | 42 | /ligand="substrate | [ST] | ||||||||
BINDING | 55 | 55 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [DN] | ||||||||
BINDING | 212 | 212 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [ENQ] |
Additional information
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Size range | 191-278 amino acids |
Related rules | None |
Fusion | Nter: MF_00835 (BioC); Cter: None |