![]() |
|
Annotation rule MF_00336 |
Accession | MF_00336 |
Dates | 1-JUN-2001 (Created) 8-MAY-2020 (Last updated, Version 40) |
Name | BioD |
Scope | Bacteria
Archaea |
Templates | P13000 (BIOD1_ECOLI); P22818 (BIOD_LYSSH); P9WPQ5 (BIOD_MYCTU); O24872 (BIOD_HELPY): [Recover all] |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. |
Catalytic activity | RHEA:15805: (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate
EC 6.3.3.3 |
Cofactor | Mg(2+) |
Pathway | Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the dethiobiotin synthetase family. |
TIGRFAMs | TIGR00347; BioD; 1; |
PIRSF | PIRSF006755; DTB_synth; 1; |
From: BIOD1_ECOLI (P13000) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 13 | 18 | ATP | [EDNSG]-[VAILSC]-G-K-[TS]-[VLTIYFH] | ||||||||
NP_BIND | 116 | 119 | ATP | E-x-x-G | ||||||||
NP_BIND | 176 | 177 | ATP | [NSMVILG]-[DEHRQTNCSMK] | ||||||||
NP_BIND | 205 | 207 | ATP | [PA]-x-[LIVSTG] | ||||||||
ACT_SITE | 38 | 38 | K | |||||||||
METAL | 17 | 17 | Magnesium | [TS] | ||||||||
METAL | 55 | 55 | Magnesium | [DNCRHK] | ||||||||
METAL | 116 | 116 | Magnesium | E | ||||||||
BINDING | 42 | 42 | Substrate | [ST] | ||||||||
BINDING | 55 | 55 | ATP | [DN] | ||||||||
BINDING | 212 | 212 | ATP | [ENQ] |
Size range | 191-278 amino acids |
Related rules | None |
Fusion | Nter: MF_00835 (BioC); Cter: None |