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HAMAP rule MF_00345

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General rule information [?]

Accession MF_00345
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name GMP_synthase_B
Template P04079 (GUAA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit B;
AltName: Full=GMP synthetase;
Gene name

Comments [?]

Function Catalyzes the synthesis of GMP from XMP.
Catalytic activity RHEA:11680: ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate
Pathway Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
Subunit Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.

Cross-references [?]

Pfam PF00958; GMP_synt_C; 1;
NCBIfam TIGR00884; GuaA_Cterm; 1;
PROSITE PS51553; GMPS_ATP_PPASE; 1; trigger=PRU00886;

Additional information [?]

Size range 303-370 amino acids
Related rules MF_00344 (GUAA supersedes the current rule)
Fusion None
Comments Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain