Home  |  Contact
Annotation rule MF_00345
Send feedback

General rule information [?]

Accession MF_00345
Dates 1-JUN-2001 (Created)
27-OCT-2018 (Last updated, Version 30)
Name GMP_synthase_B
Scope
Archaea
Template P04079 (GUAA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUAAB
Protein name
RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit B;
EC=6.3.5.2;
AltName: Full=GMP synthetase;
Gene name
guaAB

Comments [?]

Function Catalyzes the synthesis of GMP from XMP.
Catalytic activity Reaction=ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate; Xref=Rhea:RHEA:11680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58115, ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=6.3.5.2;.
Pathway Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
Subunit Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

Keywords [?]

ATP-binding
GMP biosynthesis
Ligase
Nucleotide-binding
Purine biosynthesis

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.

Cross-references [?]

Pfam PF00958; GMP_synt_C; 1;
TIGRFAMs TIGR00884; GuaA_Cterm; 1;
PROSITE PS51553; GMPS_ATP_PPASE; 1; trigger=PRU00886;

Additional information [?]

Size range 303-370 amino acids
Related rules MF_00344 (GUAA supersedes the current rule)
Fusion None
Comments Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain


View rule in raw text format (no links)