HAMAP rule MF_00345
General rule information
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| Accession | MF_00345 |
| Dates | 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 33) |
| Name | GMP_synthase_B |
| Scope(s) |
Archaea |
| Template(s) | P04079 (GUAA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00345 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GUAAB |
| Protein name | RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit B; EC=6.3.5.2; AltName: Full=GMP synthetase; |
| Gene name | Name=guaAB; |
Comments
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| FUNCTION | Catalyzes the synthesis of GMP from XMP. |
| CATALYTIC ACTIVITY | Reaction=XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+); Xref=Rhea:RHEA:11680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58115, ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=6.3.5.2; |
| PATHWAY | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. |
| SUBUNIT | Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0003922; Molecular function:GMP synthase (glutamine-hydrolyzing) activity |
| GO:0006177; Biological process:GMP biosynthetic process |
Cross-references
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Features
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Additional information
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| Size range | 303-370 amino acids |
| Related rules |
MF_00344 |
| Fusion | Nter: None Cter: None |
| Comments | Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain |