HAMAP rule MF_00345
General rule information
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| Accession | MF_00345 |
| Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 32) |
| Name | GMP_synthase_B |
| Scope | Archaea |
| Template | P04079 (GUAA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the synthesis of GMP from XMP. |
| Catalytic activity | RHEA:11680: ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate
EC 6.3.5.2 |
| Pathway | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. |
| Subunit | Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.
GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.
Cross-references
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| Pfam | PF00958; GMP_synt_C; 1; |
| NCBIfam | TIGR00884; GuaA_Cterm; 1; |
| PROSITE | PS51553; GMPS_ATP_PPASE; 1; trigger=PRU00886; |
Additional information
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| Size range | 303-370 amino acids |
| Related rules | MF_00344 (GUAA supersedes the current rule) |
| Fusion | None |
| Comments | Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain |