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HAMAP rule MF_00345

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General rule information [?]

Accession MF_00345
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name GMP_synthase_B
Scope(s) Archaea
Template(s) P04079 (GUAA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00345 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GUAAB
Protein name RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit B;
AltName: Full=GMP synthetase;
Gene name Name=guaAB;

Comments [?]

FUNCTIONCatalyzes the synthesis of GMP from XMP.
CATALYTIC ACTIVITY Reaction=ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate; Xref=Rhea:RHEA:11680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58115, ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=;
PATHWAYPurine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
SUBUNITHeterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003922; Molecular function:GMP synthase (glutamine-hydrolyzing) activity
GO:0006177; Biological process:GMP biosynthetic process

Cross-references [?]

Pfam PF00958; GMP_synt_C; 1;
NCBIfam TIGR00884; GuaA_Cterm; 1;

Features [?]

Additional information [?]

Size range 303-370 amino acids
Related rules MF_00344
Fusion Nter: None Cter: None
Comments Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain

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