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Annotation rule MF_00354
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General rule information [?]

Accession MF_00354
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 25)
Name Idi_2
Scope
Bacteria
Archaea
Templates P61615 (IDI2_SACSH); Q746I8 (IDI2_THET2); P50740 (IDI2_BACSU); Q8DUI9 (IDI2_STRMU); Q58272 (IDI2_METJA); Q9KWG2 (IDI2_STRC1): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IDI2
Protein name
RecName: Full=Isopentenyl-diphosphate delta-isomerase;
Short=IPP isomerase;
EC 5.3.3.2;
AltName: Full=Type 2 isopentenyl diphosphate isomerase;
Short=IDI-2;
AltName: Full=Isopentenyl pyrophosphate isomerase;
AltName: Full=Isopentenyl diphosphate:dimethylallyl diphosphate isomerase;
Gene name
fni

Comments [?]

Function Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Catalytic activity RHEA:23284: isopentenyl diphosphate = dimethylallyl diphosphate
EC 5.3.3.2
Cofactor FMN
NADPH
Mg(2+)
Subunit Homooctamer. Dimer of tetramers.
Subcellular location Cytoplasm.
Similarity Belongs to the IPP isomerase type 2 family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0004452; Molecular function: isopentenyl-diphosphate delta-isomerase activity.
GO:0010181; Molecular function: FMN binding.
GO:0070402; Molecular function: NADPH binding.
GO:0008299; Biological process: isoprenoid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01070; FMN_dh; 1;
TIGRFAMs TIGR02151; IPP_isom_2; 1;

Features [?]

From: IDI2_SACSH (P61615)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     66     68       FMN     [GAS]-[MIL]-T  
case <OC:Bacillus>
NP_BIND (Optional)     274     275       FMN     G-G  
else
NP_BIND (Optional)     275     277       FMN     G-x-[RK]  
end case
NP_BIND (Optional)     296     297       FMN     [AS]-x  
REGION (Optional)     7     8       Substrate binding     [RK]-K  
REGION (Optional)     96     98       Substrate binding     S-x-[RKH]  
METAL     161     161       Magnesium     E  
BINDING (Optional)     65     65       FMN     [TS]  
BINDING     96     96       FMN; via amide nitrogen     S  
BINDING     125     125       FMN     N  
BINDING     160     160       Substrate     Q  
BINDING     193     193       FMN     K  
BINDING     218     218       FMN     S  
BINDING     223     223       FMN; via amide nitrogen     T  

Additional information [?]

Size range 329-374 amino acids
Related rules None
Fusion None