HAMAP rule MF_00354
General rule information
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| Accession | MF_00354 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 29) |
| Name | Idi_2 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P61615 (IDI2_SACSH); Q746I8 (IDI2_THET2); P50740 (IDI2_BACSU); Q8DUI9 (IDI2_STRMU); Q58272 (IDI2_METJA); Q9KWG2 (IDI2_STRC1); [ Recover all ] |
| Triggered by |
HAMAP; MF_00354 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | IDI2 |
| Protein name | RecName: Full=Isopentenyl-diphosphate delta-isomerase; Short=IPP isomerase; EC=5.3.3.2; AltName: Full=Type 2 isopentenyl diphosphate isomerase; Short=IDI-2; AltName: Full=Isopentenyl pyrophosphate isomerase; AltName: Full=Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; |
| Gene name | Name=fni; |
Comments
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| FUNCTION | Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). |
| CATALYTIC ACTIVITY | Reaction=isopentenyl diphosphate = dimethylallyl diphosphate; Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769; EC=5.3.3.2; |
| COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; |
| COFACTOR | Name=NADPH; Xref=ChEBI:CHEBI:57783; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Homooctamer. Dimer of tetramers. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the IPP isomerase type 2 family. |
Keywords
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Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0004452; Molecular function:isopentenyl-diphosphate delta-isomerase activity |
| GO:0010181; Molecular function:FMN binding |
| GO:0070402; Molecular function:NADPH binding |
| GO:0008299; Biological process:isoprenoid biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: IDI2_SACSH (P61615) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 66 | 68 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[GAS]-[MIL]-T | ||||||||
| case <OC:Bacillus> | ||||||||||||
| BINDING | 274 | 275 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
G-G | ||||||||
| else | ||||||||||||
| BINDING | 275 | 277 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
G-x-[RK] | ||||||||
| end case | ||||||||||||
| BINDING | 296 | 297 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[AS]-x | ||||||||
| BINDING | 7 | 8 | /ligand="substrate" | [RK]-K | ||||||||
| BINDING | 96 | 98 | /ligand="substrate" | S-x-[RKH] | ||||||||
| BINDING | 161 | 161 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 65 | 65 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[TS] | ||||||||
| BINDING | 96 | 96 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
S | ||||||||
| BINDING | 125 | 125 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
N | ||||||||
| BINDING | 160 | 160 | /ligand="substrate" | Q | ||||||||
| BINDING | 193 | 193 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
K | ||||||||
| BINDING | 218 | 218 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
S | ||||||||
| BINDING | 223 | 223 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
T | ||||||||
Additional information
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| Size range | 329-374 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |