HAMAP logo
Due to maintenance work, this service will be unavailable Tuesday 16 between 06:00 and 06:30 - CEST. Apologies for the inconvenience.

HAMAP rule MF_00354

Send feedback

General rule information [?]

Accession MF_00354
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 29)
Name Idi_2
Scope(s) Bacteria
Archaea
Template(s) P61615 (IDI2_SACSH); Q746I8 (IDI2_THET2); P50740 (IDI2_BACSU); Q8DUI9 (IDI2_STRMU); Q58272 (IDI2_METJA); Q9KWG2 (IDI2_STRC1); [ Recover all ]
Triggered by HAMAP; MF_00354 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier IDI2
Protein name RecName: Full=Isopentenyl-diphosphate delta-isomerase;
                 Short=IPP isomerase;
                 EC=5.3.3.2;
AltName: Full=Type 2 isopentenyl diphosphate isomerase;
                 Short=IDI-2;
AltName: Full=Isopentenyl pyrophosphate isomerase;
AltName: Full=Isopentenyl diphosphate:dimethylallyl diphosphate isomerase;
Gene name Name=fni;

Comments [?]

FUNCTIONInvolved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
CATALYTIC ACTIVITY Reaction=isopentenyl diphosphate = dimethylallyl diphosphate; Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769; EC=5.3.3.2;
COFACTOR Name=FMN; Xref=ChEBI:CHEBI:58210;
COFACTOR Name=NADPH; Xref=ChEBI:CHEBI:57783;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SUBUNITHomooctamer. Dimer of tetramers.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the IPP isomerase type 2 family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0004452; Molecular function:isopentenyl-diphosphate delta-isomerase activity
GO:0010181; Molecular function:FMN binding
GO:0070402; Molecular function:NADPH binding
GO:0008299; Biological process:isoprenoid biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01070; FMN_dh; 1;
NCBIfam TIGR02151; IPP_isom_2; 1;

Features [?]

From: IDI2_SACSH (P61615)
Key From To Description Tag Condition FTGroup
BINDING 66 68 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[GAS]-[MIL]-T
case <OC:Bacillus>
BINDING 274 275 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
G-G
else
BINDING 275 277 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
G-x-[RK]
end case
BINDING 296 297 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[AS]-x
BINDING 7 8 /ligand="substrate" [RK]-K
BINDING 96 98 /ligand="substrate" S-x-[RKH]
BINDING 161 161 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E
BINDING 65 65 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[TS]
BINDING 96 96 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
S
BINDING 125 125 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
N
BINDING 160 160 /ligand="substrate" Q
BINDING 193 193 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
K
BINDING 218 218 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
S
BINDING 223 223 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
T

Additional information [?]

Size range 329-374 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)