HAMAP rule MF_00364
General rule information
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| Accession | MF_00364 |
| Dates | 1-JUN-2001 (Created)
26-JAN-2023 (Last updated, Version 30) |
| Name | NagZ |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P75949 (NAGZ_ECOLI); Q8ZQ06 (NAGZ_SALTY); Q9KU37 (NAGZ_VIBCH); [ Recover all ] |
| Triggered by |
HAMAP; MF_00364 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NAGZ |
| Protein name | RecName: Full=Beta-hexosaminidase; EC=3.2.1.52; AltName: Full=Beta-N-acetylhexosaminidase; AltName: Full=N-acetyl-beta-glucosaminidase; |
| Gene name | Name=nagZ; |
Comments
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| FUNCTION | Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. |
| CATALYTIC ACTIVITY | Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; |
| PATHWAY | Cell wall biogenesis; peptidoglycan recycling. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. |
Keywords
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| Cell cycle |
| Cell division |
| Cell shape |
| Cell wall biogenesis/degradation |
| Cytoplasm |
| Glycosidase |
| Hydrolase |
| Peptidoglycan synthesis |
Gene Ontology
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| GO:0004563; Molecular function:beta-N-acetylhexosaminidase activity |
| GO:0009254; Biological process:peptidoglycan turnover |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: NAGZ_SALTY (Q8ZQ06) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 163 | 164 | /ligand="substrate" | K-H | ||||||||
| ACT_SITE | 176 | 176 | /note="Proton donor/acceptor" | H | ||||||||
| ACT_SITE | 248 | 248 | /note="Nucleophile" | D | ||||||||
| BINDING | 62 | 62 | /ligand="substrate" | D | ||||||||
| BINDING | 70 | 70 | /ligand="substrate" | R | ||||||||
| BINDING | 133 | 133 | /ligand="substrate" | R | ||||||||
| SITE | 174 | 174 | /note="Important for catalytic activity" | D | ||||||||
Additional information
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| Size range | 300-400 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |