HAMAP rule MF_00364
General rule information
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Accession | MF_00364 |
Dates | 1-JUN-2001 (Created) 26-JAN-2023 (Last updated, Version 30) |
Name | NagZ |
Scope | Bacteria; Pseudomonadota |
Templates | P75949 (NAGZ_ECOLI); Q8ZQ06 (NAGZ_SALTY); Q9KU37 (NAGZ_VIBCH): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. |
Catalytic activity | Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; |
Pathway | Cell wall biogenesis; peptidoglycan recycling. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. |
Keywords
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Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Glycosidase
Hydrolase
Peptidoglycan synthesis
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Glycosidase
Hydrolase
Peptidoglycan synthesis
Gene Ontology
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GO:0004563; Molecular function: beta-N-acetylhexosaminidase activity.
GO:0009254; Biological process: peptidoglycan turnover.
GO:0005737; Cellular component: cytoplasm.
GO:0009254; Biological process: peptidoglycan turnover.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: NAGZ_SALTY (Q8ZQ06) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 163 | 164 | /ligand="substrate | K-H | ||||||||
ACT_SITE | 176 | 176 | Proton donor/acceptor | H | ||||||||
ACT_SITE | 248 | 248 | Nucleophile | D | ||||||||
BINDING | 62 | 62 | /ligand="substrate | D | ||||||||
BINDING | 70 | 70 | /ligand="substrate | R | ||||||||
BINDING | 133 | 133 | /ligand="substrate | R | ||||||||
SITE | 174 | 174 | Important for catalytic activity | D |
Additional information
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Size range | 300-400 amino acids |
Related rules | None |
Fusion | None |