HAMAP rule MF_00364

General rule information [?]

Accession	MF_00364
Dates	1-JUN-2001 (Created) 26-JAN-2023 (Last updated, Version 30)

Name

NagZ

Scope

Bacteria; Pseudomonadota

Templates

P75949 (NAGZ_ECOLI); Q8ZQ06 (NAGZ_SALTY); Q9KU37 (NAGZ_VIBCH): [Recover all]

Triggered by

HAMAP; MF_00364 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NAGZ

Protein name

RecName:		Full=Beta-hexosaminidase;
		EC 3.2.1.52;
AltName:		Full=Beta-N-acetylhexosaminidase;
AltName:		Full=N-acetyl-beta-glucosaminidase;

Gene name

nagZ

Comments [?]

Function	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
Catalytic activity	Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
Pathway	Cell wall biogenesis; peptidoglycan recycling.
Subcellular location	Cytoplasm.
Similarity	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Keywords [?]

Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Glycosidase
Hydrolase
Peptidoglycan synthesis

Gene Ontology [?]

GO:0004563; Molecular function: beta-N-acetylhexosaminidase activity.
GO:0009254; Biological process: peptidoglycan turnover.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00933; Glyco_hydro_3; 1;
PROSITE	PS00775; GLYCOSYL_HYDROL_F3; 1;

Features [?]

From: NAGZ_SALTY (Q8ZQ06)

Key From To Description Tag Condition FTGroup

BINDING 163 164 /ligand="substrate K-H

ACT_SITE 176 176 Proton donor/acceptor H

ACT_SITE 248 248 Nucleophile D

BINDING 62 62 /ligand="substrate D

BINDING 70 70 /ligand="substrate R

BINDING 133 133 /ligand="substrate R

SITE 174 174 Important for catalytic activity D

Additional information [?]

Size range	300-400 amino acids
Related rules	None
Fusion	None

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