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Annotation rule MF_00364 |
Accession | MF_00364 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 27) |
Name | NagZ |
Scope | Bacteria; Proteobacteria |
Templates | P75949 (NAGZ_ECOLI); Q8ZQ06 (NAGZ_SALTY); Q9KU37 (NAGZ_VIBCH): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. |
Catalytic activity | Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; |
Pathway | Cell wall biogenesis; peptidoglycan recycling. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. |
From: NAGZ_SALTY (Q8ZQ06) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 163 | 164 | Substrate binding | K-H | ||||||||
ACT_SITE | 176 | 176 | Proton donor/acceptor | H | ||||||||
ACT_SITE | 248 | 248 | Nucleophile | D | ||||||||
BINDING | 62 | 62 | Substrate | D | ||||||||
BINDING | 70 | 70 | Substrate | R | ||||||||
BINDING | 133 | 133 | Substrate | R | ||||||||
SITE | 174 | 174 | Important for catalytic activity | D |
Size range | 300-400 amino acids |
Related rules | None |
Fusion | None |