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Annotation rule MF_00364
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General rule information [?]

Accession MF_00364
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 27)
Name NagZ
Scope
Bacteria; Proteobacteria
Templates P75949 (NAGZ_ECOLI); Q8ZQ06 (NAGZ_SALTY); Q9KU37 (NAGZ_VIBCH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NAGZ
Protein name
RecName: Full=Beta-hexosaminidase;
EC 3.2.1.52;
AltName: Full=Beta-N-acetylhexosaminidase;
AltName: Full=N-acetyl-beta-glucosaminidase;
Gene name
nagZ

Comments [?]

Function Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
Catalytic activity Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
Pathway Cell wall biogenesis; peptidoglycan recycling.
Subcellular location Cytoplasm.
Similarity Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Keywords [?]

Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Glycosidase
Hydrolase
Peptidoglycan synthesis

Gene Ontology [?]

GO:0004563; Molecular function: beta-N-acetylhexosaminidase activity.
GO:0009254; Biological process: peptidoglycan turnover.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00933; Glyco_hydro_3; 1;
PROSITE PS00775; GLYCOSYL_HYDROL_F3; 1;

Features [?]

From: NAGZ_SALTY (Q8ZQ06)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     163     164       Substrate binding     K-H  
ACT_SITE     176     176       Proton donor/acceptor     H  
ACT_SITE     248     248       Nucleophile     D  
BINDING     62     62       Substrate     D  
BINDING     70     70       Substrate     R  
BINDING     133     133       Substrate     R  
SITE     174     174       Important for catalytic activity     D  

Additional information [?]

Size range 300-400 amino acids
Related rules None
Fusion None


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