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HAMAP rule MF_00364

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General rule information [?]

Accession MF_00364
Dates 1-JUN-2001 (Created)
26-JAN-2023 (Last updated, Version 30)
Name NagZ
Scope(s) Bacteria
Template(s) P75949 (NAGZ_ECOLI); Q8ZQ06 (NAGZ_SALTY); Q9KU37 (NAGZ_VIBCH); [ Recover all ]
Triggered by HAMAP; MF_00364 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NAGZ
Protein name RecName: Full=Beta-hexosaminidase;
AltName: Full=Beta-N-acetylhexosaminidase;
AltName: Full=N-acetyl-beta-glucosaminidase;
Gene name Name=nagZ;

Comments [?]

FUNCTIONPlays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
CATALYTIC ACTIVITY Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=;
PATHWAYCell wall biogenesis; peptidoglycan recycling.
SIMILARITYBelongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004563; Molecular function:beta-N-acetylhexosaminidase activity
GO:0009254; Biological process:peptidoglycan turnover
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00933; Glyco_hydro_3; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 163 164 /ligand="substrate" K-H
ACT_SITE 176 176 /note="Proton donor/acceptor" H
ACT_SITE 248 248 /note="Nucleophile" D
BINDING 62 62 /ligand="substrate" D
BINDING 70 70 /ligand="substrate" R
BINDING 133 133 /ligand="substrate" R
SITE 174 174 /note="Important for catalytic activity" D

Additional information [?]

Size range 300-400 amino acids
Related rules None
Fusion Nter: None Cter: None

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