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HAMAP rule MF_00372

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General rule information [?]

Accession MF_00372
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name HutI
Templates P42084 (HUTI_BACSU); Q8U8Z6 (HUTI_AGRFC); A0KF84 (HUTI_AERHH): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Imidazolonepropionase;
AltName: Full=Imidazolone-5-propionate hydrolase;
Gene name

Comments [?]

Function Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
Catalytic activity RHEA:23660: 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc or iron ion per subunit.
end case
Pathway Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
Subcellular location Cytoplasm.
Similarity Belongs to the metallo-dependent hydrolases superfamily. HutI family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0050480; Molecular function: imidazolonepropionase activity.
GO:0006548; Biological process: histidine catabolic process.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
NCBIfam TIGR01224; HutI; 1;

Features [?]

From: HUTI_BACSU (P42084)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     80     80       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034     H   1
BINDING     80     80       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1
BINDING     82     82       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034     H   1
BINDING     82     82       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1
BINDING     249     249       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034     H   1
BINDING     249     249       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1
BINDING     324     324       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034     [DN]   1
BINDING     324     324       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     [DN]   1
BINDING     89     89       /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893     R  
BINDING     152     152       /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893     Y  
BINDING     152     152       /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928     Y  
BINDING     185     185       /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893     H  
BINDING     252     252       /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893     [EQ]  
BINDING     326     326       /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928     N  
BINDING     328     328       /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928     G  
BINDING     329     329       /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893     [TS]  

Additional information [?]

Size range 388-456 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: MF_00229 (hutH)