HAMAP rule MF_00372
General rule information
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Accession | MF_00372 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 33) |
Name | HutI |
Scope | Bacteria
Archaea |
Templates | P42084 (HUTI_BACSU); Q8U8Z6 (HUTI_AGRFC); A0KF84 (HUTI_AERHH): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. |
Catalytic activity | RHEA:23660: 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate
EC 3.5.2.7 |
case <FTGroup:1>
end case
Pathway | Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the metallo-dependent hydrolases superfamily. HutI family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0050480; Molecular function: imidazolonepropionase activity.
GO:0006548; Biological process: histidine catabolic process.
GO:0006548; Biological process: histidine catabolic process.
case <FTGroup:1>
end case
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: HUTI_BACSU (P42084) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 80 | 80 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 | H | 1 | |||||||
BINDING | 80 | 80 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 82 | 82 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 | H | 1 | |||||||
BINDING | 82 | 82 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 249 | 249 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 | H | 1 | |||||||
BINDING | 249 | 249 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 324 | 324 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 | [DN] | 1 | |||||||
BINDING | 324 | 324 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | [DN] | 1 | |||||||
BINDING | 89 | 89 | /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 | R | ||||||||
BINDING | 152 | 152 | /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 | Y | ||||||||
BINDING | 152 | 152 | /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928 | Y | ||||||||
BINDING | 185 | 185 | /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 | H | ||||||||
BINDING | 252 | 252 | /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 | [EQ] | ||||||||
BINDING | 326 | 326 | /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928 | N | ||||||||
BINDING | 328 | 328 | /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928 | G | ||||||||
BINDING | 329 | 329 | /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 | [TS] |
Additional information
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Size range | 388-456 amino acids |
Related rules | None |
Fusion | Nter: <Unknown>; Cter: MF_00229 (hutH) |