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Annotation rule MF_00372
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General rule information [?]

Accession MF_00372
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 29)
Name HutI
Scope
Bacteria
Archaea
Templates P42084 (HUTI_BACSU); Q8U8Z6 (HUTI_AGRFC): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HUTI
Protein name
RecName: Full=Imidazolonepropionase;
EC 3.5.2.7;
AltName: Full=Imidazolone-5-propionate hydrolase;
Gene name
hutI

Comments [?]

Catalytic activity RHEA:23660: 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate
EC 3.5.2.7
case <FTGroup:1>
Cofactor Zn(2+)
Fe(2+)
Note: Binds 1 zinc or iron ion per subunit.
end case
Pathway Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
Subcellular location Cytoplasm.
Similarity Belongs to the metallo-dependent hydrolases superfamily. HutI family.

Keywords [?]

Cytoplasm
Hydrolase
Histidine metabolism
case <FTGroup:1>
Metal-binding
Iron
Zinc
end case

Gene Ontology [?]

GO:0050480; Molecular function: imidazolonepropionase activity.
GO:0006548; Biological process: histidine catabolic process.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
TIGRFAMs TIGR01224; HutI; 1;

Features [?]

From: HUTI_BACSU (P42084)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     80     80       Zinc or iron     H   1
METAL     82     82       Zinc or iron     H   1
METAL     249     249       Zinc or iron     H   1
METAL     324     324       Zinc or iron     [DN]   1
BINDING     89     89       Substrate     R  
BINDING     102     102       Substrate     Y  
BINDING     152     152       Substrate     Y  
BINDING     185     185       Substrate     H  
BINDING     252     252       Substrate     [EQ]  

Additional information [?]

Size range 388-456 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: MF_00229 (hutH)


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