HAMAP rule MF_00372

General rule information [?]

Accession	MF_00372
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 33)

Name

HutI

Scope

Bacteria

Archaea

Templates

P42084 (HUTI_BACSU); Q8U8Z6 (HUTI_AGRFC); A0KF84 (HUTI_AERHH): [Recover all]

Triggered by

HAMAP; MF_00372 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HUTI

Protein name

RecName:		Full=Imidazolonepropionase;
		EC 3.5.2.7;
AltName:		Full=Imidazolone-5-propionate hydrolase;

Gene name

hutI

Comments [?]

Function	Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
Catalytic activity	RHEA:23660: 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate EC 3.5.2.7

case <FTGroup:1>

Cofactor

Zn(2+)
Fe(3+)
Note: Binds 1 zinc or iron ion per subunit.

end case

Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
Subcellular location	Cytoplasm.
Similarity	Belongs to the metallo-dependent hydrolases superfamily. HutI family.

Keywords [?]

Cytoplasm
Hydrolase
Histidine metabolism

case <FTGroup:1>

Metal-binding
Iron
Zinc

end case

Gene Ontology [?]

GO:0050480; Molecular function: imidazolonepropionase activity.
GO:0006548; Biological process: histidine catabolic process.

case <FTGroup:1>

GO:0005506; Molecular function: iron ion binding.
GO:0008270; Molecular function: zinc ion binding.

end case

GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01979; Amidohydro_1; 1;
NCBIfam	TIGR01224; HutI; 1;

Features [?]

From: HUTI_BACSU (P42084)

Key From To Description Tag Condition FTGroup

BINDING 80 80 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 H 1

BINDING 80 80 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 82 82 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 H 1

BINDING 82 82 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 249 249 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 H 1

BINDING 249 249 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 324 324 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034 [DN] 1

BINDING 324 324 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 [DN] 1

BINDING 89 89 /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 R

BINDING 152 152 /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 Y

BINDING 152 152 /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928 Y

BINDING 185 185 /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 H

BINDING 252 252 /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 [EQ]

BINDING 326 326 /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928 N

BINDING 328 328 /ligand="N-formimidoyl-L-glutamate" /ligand_id="ChEBI:CHEBI:58928 G

BINDING 329 329 /ligand="4-imidazolone-5-propanoate" /ligand_id="ChEBI:CHEBI:77893 [TS]

Additional information [?]

Size range	388-456 amino acids
Related rules	None
Fusion	Nter: <Unknown>; Cter: MF_00229 (hutH)

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