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HAMAP rule MF_00375
General rule information
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Accession | MF_00375 |
Dates | 1-JUN-2001 (Created)
15-FEB-2024 (Last updated, Version 53) |
Name | HemL_aminotrans_3 |
Scope(s) |
Bacteria Archaea |
Template(s) | P23893 (GSA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00375 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GSA |
Protein name | RecName: Full=Glutamate-1-semialdehyde 2,1-aminomutase; Short=GSA; EC=5.4.3.8; AltName: Full=Glutamate-1-semialdehyde aminotransferase; Short=GSA-AT; |
Gene name | Name=hemL; |
Comments
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CATALYTIC ACTIVITY | Reaction=(S)-4-amino-5-oxopentanoate = 5-aminolevulinate; Xref=Rhea:RHEA:14265, ChEBI:CHEBI:57501, ChEBI:CHEBI:356416; EC=5.4.3.8; |
COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
case not <Property:PHOTOSYN> | |
PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. |
end case | |
case <Property:PHOTOSYN> | |
PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. |
PATHWAY | Porphyrin-containing compound metabolism; chlorophyll biosynthesis. |
end case | |
case <OC:Bacteria> | |
SUBUNIT | Homodimer. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. |
Keywords
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Cytoplasm | |
Porphyrin biosynthesis | |
case <Property:PHOTOSYN> | |
Chlorophyll biosynthesis | |
end case | |
Isomerase | |
Pyridoxal phosphate |
Gene Ontology
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GO:0042286; Molecular function:glutamate-1-semialdehyde 2,1-aminomutase activity | |
case <Property:PHOTOSYN> | |
GO:0015995; Biological process:chlorophyll biosynthetic process | |
end case | |
GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process | |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: GSA_ECOLI (P23893) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 265 | 265 | /note="N6-(pyridoxal phosphate)lysine" | K |
Additional information
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Size range | 412-466 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | A third putative copy exists in HALH5. A second divergent copy exists in AERPE. |