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HAMAP rule MF_00375

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General rule information [?]

Accession MF_00375
Dates 1-JUN-2001 (Created)
15-FEB-2024 (Last updated, Version 53)
Name HemL_aminotrans_3
Scope(s) Bacteria
Archaea
Template(s) P23893 (GSA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00375 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GSA
Protein name RecName: Full=Glutamate-1-semialdehyde 2,1-aminomutase;
                 Short=GSA;
                 EC=5.4.3.8;
AltName: Full=Glutamate-1-semialdehyde aminotransferase;
                 Short=GSA-AT;
Gene name Name=hemL;

Comments [?]

CATALYTIC ACTIVITY Reaction=(S)-4-amino-5-oxopentanoate = 5-aminolevulinate; Xref=Rhea:RHEA:14265, ChEBI:CHEBI:57501, ChEBI:CHEBI:356416; EC=5.4.3.8;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
case not <Property:PHOTOSYN>
PATHWAYPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
end case
case <Property:PHOTOSYN>
PATHWAYPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
PATHWAYPorphyrin-containing compound metabolism; chlorophyll biosynthesis.
end case
case <OC:Bacteria>
SUBUNITHomodimer.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Keywords [?]


Gene Ontology [?]

GO:0042286; Molecular function:glutamate-1-semialdehyde 2,1-aminomutase activity
case <Property:PHOTOSYN>
GO:0015995; Biological process:chlorophyll biosynthetic process
end case
GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00202; Aminotran_3; 1;
NCBIfam TIGR00713; HemL; 1;
PROSITE PS00600; AA_TRANSFER_CLASS_3; 1;

Features [?]

From: GSA_ECOLI (P23893)
Key From To Description Tag Condition FTGroup
MOD_RES 265 265 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 412-466 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments A third putative copy exists in HALH5. A second divergent copy exists in AERPE.



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