HAMAP rule MF_00390

General rule information [?]

Accession	MF_00390
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 23)

Name	Thiourid_synth_D

Scope

Bacteria; Enterobacterales

Template

P45532 (TUSD_ECOLI)

Triggered by

HAMAP; MF_00390 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TUSD

Protein name

RecName:		Full=Sulfurtransferase TusD;
		EC 2.8.1.-;
AltName:		Full=tRNA 2-thiouridine synthesizing protein D;

Gene name

tusD

Comments [?]

Function	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.
Subunit	Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
Subcellular location	Cytoplasm.
Similarity	Belongs to the DsrE/TusD family.

Keywords [?]

Cytoplasm
Transferase
tRNA processing

Gene Ontology [?]

GO:0016783; Molecular function: sulfurtransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02635; DrsE; 1;
NCBIfam	TIGR03012; sulf_tusD_dsrE; 1;

Features [?]

From: TUSD_ECOLI (P45532)

Key From To Description Tag Condition FTGroup

ACT_SITE 78 78 Cysteine persulfide intermediate C

Additional information [?]

Size range	128-131 amino acids
Related rules	None
Fusion	None

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