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HAMAP rule MF_00400

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General rule information [?]

Accession MF_00400
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 40)
Name MdtK
Scope(s) Bacteria
Template(s) P37340 (MDTK_ECOLI); Q7WTR3 (MDTK_ERWAM); [ Recover all ]
Triggered by HAMAP; MF_00400 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MDTK
Protein name RecName: Full=Multidrug resistance protein MdtK;
AltName: Full=Multidrug-efflux transporter;
Gene name Name=mdtK;

Comments [?]

FUNCTIONMultidrug efflux pump that functions probably as a Na(+)/drug antiporter.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.

Keywords [?]

Gene Ontology [?]

GO:0015297; Molecular function:antiporter activity
GO:0042910; Molecular function:xenobiotic transmembrane transporter activity
GO:0006855; Biological process:xenobiotic transmembrane transport
GO:0006814; Biological process:sodium ion transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01554; MatE; 2;
NCBIfam TIGR00797; MatE; 1;
General Transmembrane; -; 12;

Features [?]

Additional information [?]

Size range 457-457 amino acids
Related rules None
Fusion Nter: None Cter: None

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