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Annotation rule MF_00400
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General rule information [?]

Accession MF_00400
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 38)
Name MdtK
Bacteria; Enterobacterales
Templates P37340 (MDTK_ECOLI); Q7WTR3 (MDTK_ERWAM): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Multidrug resistance protein MdtK;
AltName: Full=Multidrug-efflux transporter;
Gene name

Comments [?]

Function Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0015297; Molecular function: antiporter activity.
GO:0042910; Molecular function: xenobiotic transmembrane transporter activity.
GO:0006855; Biological process: drug transmembrane transport.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01554; MatE; 2;
TIGRFAMs TIGR00797; MatE; 1;

Computed features [?]

General Transmembrane; -; 12; trigger=yes;

Additional information [?]

Size range 457-457 amino acids
Related rules None
Fusion None