HAMAP rule MF_00400

General rule information [?]

Accession	MF_00400
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 40)
Name	MdtK
Scope(s)	Bacteria Enterobacterales
Template(s)	P37340 (MDTK_ECOLI); Q7WTR3 (MDTK_ERWAM); [ Recover all ]
Triggered by	HAMAP; MF_00400 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MDTK
Protein name	RecName: Full=Multidrug resistance protein MdtK; AltName: Full=Multidrug-efflux transporter;
Gene name	Name=mdtK;

Comments [?]

FUNCTION	Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.

Keywords [?]

Antiport
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Ion transport
Membrane
Sodium
Sodium transport
Transmembrane
Transport
Transmembrane helix

Gene Ontology [?]

GO:0015297; Molecular function:antiporter activity

GO:0042910; Molecular function:xenobiotic transmembrane transporter activity

GO:0006855; Biological process:xenobiotic transmembrane transport

GO:0006814; Biological process:sodium ion transport

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]