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Annotation rule MF_00403
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General rule information [?]

Accession MF_00403
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 39)
Name Ribosomal_S12
Scope
Bacteria
Archaea
Plastid
Templates P21472 (RS12_BACSU); P0A7S3 (RS12_ECOLI); Q6N4T2 (RS12_RHOPA); Q5SHN3 (RS12_THET8); P14149 (RR12_CHLRE): [Recover all]
case <OC:Bacteria> or <OG:Chloroplast>
Triggered by
end case

case <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Bacteria> and not <OC:Cyanobacteria>
Identifier
RS12
Protein name
RecName: Full=30S ribosomal protein S12;
Gene name
rpsL
end case
case <OC:Cyanobacteria>
Identifier
RS12
Protein name
RecName: Full=30S ribosomal protein S12;
Gene name
rpsL, rps12
end case
case <OC:Archaea>
Identifier
RS12
Protein name
RecName: Full=30S ribosomal protein S12;
Gene name
rps12
end case
case <OG:Chloroplast>
Identifier
RR12
Protein name
RecName: Full=30S ribosomal protein S12, chloroplastic;
Gene name
rps12
end case

Comments [?]

case <OC:Bacteria>
Function With S4 and S5 plays an important role in translational accuracy.
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
Subunit Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
else case <OC:Archaea>
Function With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.
Subunit Part of the 30S ribosomal subunit.
end case
case <OG:Chloroplast>
Function With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.
Subunit Part of the 30S ribosomal subunit.
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the universal ribosomal protein uS12 family.

Keywords [?]

case <FTTag:acet>
Acetylation
end case
Ribonucleoprotein
Ribosomal protein
RNA-binding
rRNA-binding
case <OC:Bacteria>
tRNA-binding
end case

Gene Ontology [?]

GO:0019843; Molecular function: rRNA binding.
case <OC:Bacteria>
GO:0000049; Molecular function: tRNA binding.
end case
GO:0006412; Biological process: translation.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF00164; Ribosomal_S12; 1;
PRINTS PR01034; RIBOSOMALS12; 1;
TIGRFAMs TIGR00981; RpsL_bact; 1;
TIGR00982; S23_S12_E_A; 1;
PROSITE PS00055; RIBOSOMAL_S12; 1;

Features [?]

case <OC:Escherichia> or <OC:Shigella>
From: RS12_ECOLI (P0A7S3)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     108     108       N6-acetyllysine   acet   K  
end case

Additional information [?]

case <OC:Bacteria>
Size range 117-144 amino acids
end case
case <OC:Archaea>
Size range 141-151 amino acids
end case
Related rules None
Fusion None


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