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HAMAP rule MF_00403

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General rule information [?]

Accession MF_00403
Dates 1-JUN-2001 (Created)
21-SEP-2023 (Last updated, Version 44)
Name Ribosomal_uS12
Scope(s) Bacteria
Archaea
Plastid
Template(s) P21472 (RS12_BACSU); P0A7S3 (RS12_ECOLI); Q6N4T2 (RS12_RHOPA); Q5SHN3 (RS12_THET8); P14149 (RR12_CHLRE); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OG:Chloroplast>
HAMAP; MF_00403_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_00403_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria> and not <OC:Cyanobacteriota>
Identifier RS12
Protein name RecName: Full=Small ribosomal subunit protein uS12;
Gene name Name=rpsL;
end case
case <OC:Cyanobacteriota>
Identifier RS12
Protein name RecName: Full=Small ribosomal subunit protein uS12;
Gene name Name=rpsL; Synonyms=rps12;
end case
case <OC:Archaea>
Identifier RS12
Protein name RecName: Full=Small ribosomal subunit protein uS12;
Gene name Name=rps12;
end case
case <OG:Chloroplast>
Identifier RR12
Protein name RecName: Full=Small ribosomal subunit protein uS12c;
Gene name Name=rps12;
end case

Comments [?]

case <OC:Bacteria>
FUNCTIONWith S4 and S5 plays an important role in translational accuracy.
FUNCTIONInteracts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
SUBUNITPart of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
else case <OC:Archaea>
FUNCTIONWith S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.
SUBUNITPart of the 30S ribosomal subunit.
end case
case <OG:Chloroplast>
FUNCTIONWith S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.
SUBUNITPart of the 30S ribosomal subunit.
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the universal ribosomal protein uS12 family.

Keywords [?]

case <FTTag:acet>
Acetylation
end case
Ribonucleoprotein
Ribosomal protein
RNA-binding
rRNA-binding
case <OC:Bacteria>
tRNA-binding
end case

Gene Ontology [?]

GO:0019843; Molecular function:rRNA binding
case <OCellular component:Bacteria>
GO:0000049; Molecular function:tRNA binding
end case
GO:0006412; Biological process:translation
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF00164; Ribosomal_S12; 1;
PRINTS PR01034; RIBOSOMALS12; 1;
NCBIfam TIGR00981; RpsL_bact; 1;
NCBIfam TIGR00982; S23_S12_E_A; 1;
PROSITE PS00055; RIBOSOMAL_S12; 1;

Features [?]

From: RS12_ECOLI (P0A7S3)
Key From To Description Tag Condition FTGroup
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 108 108 /note="N6-acetyllysine" acet K
end case

Additional information [?]

Size range 141-151 amino acids
Related rules None
Fusion Nter: None Cter: None



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