HAMAP rule MF_00403
General rule information
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| Accession | MF_00403 |
| Dates | 1-JUN-2001 (Created)
21-SEP-2023 (Last updated, Version 44) |
| Name | Ribosomal_uS12 |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | P21472 (RS12_BACSU); P0A7S3 (RS12_ECOLI); Q6N4T2 (RS12_RHOPA); Q5SHN3 (RS12_THET8); P14149 (RR12_CHLRE); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OG:Chloroplast>
HAMAP; MF_00403_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_00403_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Bacteria> and not <OC:Cyanobacteriota> | |
| Identifier | RS12 |
| Protein name | RecName: Full=Small ribosomal subunit protein uS12; |
| Gene name | Name=rpsL; |
| end case | |
| case <OC:Cyanobacteriota> | |
| Identifier | RS12 |
| Protein name | RecName: Full=Small ribosomal subunit protein uS12; |
| Gene name | Name=rpsL; Synonyms=rps12; |
| end case | |
| case <OC:Archaea> | |
| Identifier | RS12 |
| Protein name | RecName: Full=Small ribosomal subunit protein uS12; |
| Gene name | Name=rps12; |
| end case | |
| case <OG:Chloroplast> | |
| Identifier | RR12 |
| Protein name | RecName: Full=Small ribosomal subunit protein uS12c; |
| Gene name | Name=rps12; |
| end case | |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | With S4 and S5 plays an important role in translational accuracy. |
| FUNCTION | Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. |
| SUBUNIT | Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex. |
| else case <OC:Archaea> | |
| FUNCTION | With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. |
| SUBUNIT | Part of the 30S ribosomal subunit. |
| end case | |
| case <OG:Chloroplast> | |
| FUNCTION | With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. |
| SUBUNIT | Part of the 30S ribosomal subunit. |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the universal ribosomal protein uS12 family. |
Keywords
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| case <FTTag:acet> | |
| Acetylation | |
| end case | |
| Ribonucleoprotein | |
| Ribosomal protein | |
| RNA-binding | |
| rRNA-binding | |
| case <OC:Bacteria> | |
| tRNA-binding | |
| end case | |
Gene Ontology
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| GO:0019843; Molecular function:rRNA binding | |
| case <OCellular component:Bacteria> | |
| GO:0000049; Molecular function:tRNA binding | |
| end case | |
| GO:0006412; Biological process:translation | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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| Pfam | PF00164; Ribosomal_S12; 1; |
| PRINTS | PR01034; RIBOSOMALS12; 1; |
| NCBIfam | TIGR00981; RpsL_bact; 1; |
| NCBIfam | TIGR00982; S23_S12_E_A; 1; |
| PROSITE | PS00055; RIBOSOMAL_S12; 1; |
Features
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| From: RS12_ECOLI (P0A7S3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 108 | 108 | /note="N6-acetyllysine" | acet | K | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 141-151 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |