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HAMAP rule MF_00405
General rule information
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| Accession | MF_00405 |
| Dates | 1-JUN-2001 (Created)
2-FEB-2024 (Last updated, Version 34) |
| Name | FabA |
| Scope(s) |
Bacteria |
| Template(s) | P0A6Q3 (FABA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00405 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FABA |
| Protein name | RecName: Full=3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; EC=4.2.1.59; AltName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA; AltName: Full=Beta-hydroxydecanoyl thioester dehydrase; AltName: Full=Trans-2-decenoyl-[acyl-carrier-protein] isomerase; EC=5.3.3.14; |
| Gene name | Name=fabA; |
Comments
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| FUNCTION | Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. |
| CATALYTIC ACTIVITY | Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59; |
| CATALYTIC ACTIVITY | Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639, ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467; |
| CATALYTIC ACTIVITY | Reaction=(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]; Xref=Rhea:RHEA:23568, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9927, ChEBI:CHEBI:78467, ChEBI:CHEBI:78798; EC=5.3.3.14; |
| PATHWAY | Lipid metabolism; fatty acid biosynthesis. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the thioester dehydratase family. FabA subfamily. |
Keywords
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| Cytoplasm |
| Fatty acid biosynthesis |
| Fatty acid metabolism |
| Isomerase |
| Lipid biosynthesis |
| Lipid metabolism |
| Lyase |
Gene Ontology
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| GO:0008693; Molecular function:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity |
| GO:0034017; Molecular function:trans-2-decenoyl-acyl-carrier-protein isomerase activity |
| GO:0006636; Biological process:unsaturated fatty acid biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: FABA_ECOLI (P0A6Q3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 71 | 71 | H | |||||||||
Additional information
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| Size range | 170-184 amino acids |
| Related rules |
MF_00406 |
| Fusion | Nter: None Cter: None |