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Annotation rule MF_00405
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General rule information [?]

Accession MF_00405
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 31)
Name FabA
Scope
Bacteria
Template P0A6Q3 (FABA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FABA
Protein name
RecName: Full=3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase;
EC 4.2.1.59;
AltName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA;
AltName: Full=Beta-hydroxydecanoyl thioester dehydrase;
AltName: Full=Trans-2-decenoyl-[acyl-carrier-protein] isomerase;
EC 5.3.3.14;
Gene name
fabA

Comments [?]

Function Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
Catalytic activity RHEA:13097: a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
EC 4.2.1.59
RHEA:41860: (3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O
RHEA:23568: (2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]
EC 5.3.3.14
Pathway Lipid metabolism; fatty acid biosynthesis.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the thioester dehydratase family. FabA subfamily.

Keywords [?]

Cytoplasm
Fatty acid biosynthesis
Fatty acid metabolism
Isomerase
Lipid biosynthesis
Lipid metabolism
Lyase

Gene Ontology [?]

GO:0008693; Molecular function: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity.
GO:0034017; Molecular function: trans-2-decenoyl-acyl-carrier-protein isomerase activity.
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF07977; FabA; 1;
TIGRFAMs TIGR01749; FabA; 1;

Features [?]

From: FABA_ECOLI (P0A6Q3)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     71     71             H  

Additional information [?]

Size range 170-184 amino acids
Related rules MF_00406 (FABZ)
Fusion None


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