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HAMAP rule MF_00405

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General rule information [?]

Accession MF_00405
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name FabA
Scope(s) Bacteria
Template(s) P0A6Q3 (FABA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00405 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FABA
Protein name RecName: Full=3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase;
AltName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA;
AltName: Full=Beta-hydroxydecanoyl thioester dehydrase;
AltName: Full=Trans-2-decenoyl-[acyl-carrier-protein] isomerase;
Gene name Name=fabA;

Comments [?]

FUNCTIONNecessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
CATALYTIC ACTIVITY Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=;
CATALYTIC ACTIVITY Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639, ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467;
CATALYTIC ACTIVITY Reaction=(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]; Xref=Rhea:RHEA:23568, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9927, ChEBI:CHEBI:78467, ChEBI:CHEBI:78798; EC=;
PATHWAYLipid metabolism; fatty acid biosynthesis.
SIMILARITYBelongs to the thioester dehydratase family. FabA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008693; Molecular function:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
GO:0034017; Molecular function:trans-2-decenoyl-acyl-carrier-protein isomerase activity
GO:0006633; Biological process:fatty acid biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF07977; FabA; 1;
NCBIfam TIGR01749; FabA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 71 71 H

Additional information [?]

Size range 170-184 amino acids
Related rules MF_00406
Fusion Nter: None Cter: None

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