HAMAP rule MF_00412

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00412
Accession	MF_00412
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 26)
Name	ProA
Scope(s)	Bacteria Archaea
Template(s)	P07004; [ Recover all ]
Triggered by	HAMAP; MF_00412 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PROA
Protein name	RecName: Full=Gamma-glutamyl phosphate reductase; Short=GPR; EC=1.2.1.41; AltName: Full=Glutamate-5-semialdehyde dehydrogenase; AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase; Short=GSA dehydrogenase;
Gene name	Name=proA;

Comments [?]

FUNCTION	Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY	Reaction=L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+); Xref=Rhea:RHEA:19541, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58066, ChEBI:CHEBI:58274, ChEBI:CHEBI:58349; EC=1.2.1.41;
PATHWAY	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the gamma-glutamyl phosphate reductase family.

Keywords [?]

Gene Ontology [?]

GO:0004350; Molecular function:glutamate-5-semialdehyde dehydrogenase activity

GO:0055129; Biological process:L-proline biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]