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Annotation rule MF_00412
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General rule information [?]

Accession MF_00412
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 38)
Name ProA
Scope
Bacteria
Archaea
Template P07004 (PROA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PROA
Protein name
RecName: Full=Gamma-glutamyl phosphate reductase;
Short=GPR;
EC 1.2.1.41;
AltName: Full=Glutamate-5-semialdehyde dehydrogenase;
AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase;
Short=GSA dehydrogenase;
Gene name
proA

Comments [?]

Function Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Catalytic activity RHEA:19541: L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH
EC 1.2.1.41
Pathway Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
Subcellular location Cytoplasm.
Similarity Belongs to the gamma-glutamyl phosphate reductase family.

Keywords [?]


Gene Ontology [?]

GO:0004350; Molecular function: glutamate-5-semialdehyde dehydrogenase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00171; Aldedh; 1;
PIRSF PIRSF000151; GPR; 1;
TIGRFAMs TIGR00407; ProA; 1;
PROSITE PS01223; PROA; 1;

Additional information [?]

Size range 370-500 amino acids
Related rules None
Fusion None