HAMAP rule MF_00412

General rule information [?]

Accession	MF_00412
Dates	1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 38)

Name

ProA

Scope

Bacteria

Archaea

Template

P07004 (PROA_ECOLI)

Triggered by

HAMAP; MF_00412 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PROA

Protein name

RecName:		Full=Gamma-glutamyl phosphate reductase;
		Short=GPR;
		EC 1.2.1.41;
AltName:		Full=Glutamate-5-semialdehyde dehydrogenase;
AltName:		Full=Glutamyl-gamma-semialdehyde dehydrogenase;
		Short=GSA dehydrogenase;

Gene name

proA

Comments [?]

Function	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Catalytic activity	RHEA:19541: L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH EC 1.2.1.41
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
Subcellular location	Cytoplasm.
Similarity	Belongs to the gamma-glutamyl phosphate reductase family.

Keywords [?]

Cytoplasm
Oxidoreductase
Amino-acid biosynthesis
Proline biosynthesis
NADP

Gene Ontology [?]

GO:0004350; Molecular function: glutamate-5-semialdehyde dehydrogenase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00171; Aldedh; 1;
PIRSF	PIRSF000151; GPR; 1;
TIGRFAMs	TIGR00407; ProA; 1;
PROSITE	PS01223; PROA; 1;

Additional information [?]

Size range	370-500 amino acids
Related rules	None
Fusion	None

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