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HAMAP rule MF_00412

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General rule information [?]

Accession MF_00412
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name ProA
Scope(s) Bacteria
Template(s) P07004 (PROA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00412 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PROA
Protein name RecName: Full=Gamma-glutamyl phosphate reductase;
AltName: Full=Glutamate-5-semialdehyde dehydrogenase;
AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase;
                 Short=GSA dehydrogenase;
Gene name Name=proA;

Comments [?]

FUNCTIONCatalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY Reaction=L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L- glutamyl 5-phosphate + NADPH; Xref=Rhea:RHEA:19541, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58066, ChEBI:CHEBI:58274, ChEBI:CHEBI:58349; EC=;
PATHWAYAmino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
SIMILARITYBelongs to the gamma-glutamyl phosphate reductase family.

Keywords [?]

Gene Ontology [?]

GO:0004350; Molecular function:glutamate-5-semialdehyde dehydrogenase activity
GO:0006561; Biological process:proline biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00171; Aldedh; 1;
PIRSF PIRSF000151; GPR; 1;
NCBIfam TIGR00407; ProA; 1;

Features [?]

Additional information [?]

Size range 370-500 amino acids
Related rules None
Fusion Nter: None Cter: None

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