HAMAP rule MF_00412
General rule information
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Accession | MF_00412 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 38) |
Name | ProA |
Scope | Bacteria
Archaea |
Template | P07004 (PROA_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. |
Catalytic activity | RHEA:19541: L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH
EC 1.2.1.41 |
Pathway | Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the gamma-glutamyl phosphate reductase family. |
Keywords
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Gene Ontology
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GO:0004350; Molecular function: glutamate-5-semialdehyde dehydrogenase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00171; Aldedh; 1; |
PIRSF | PIRSF000151; GPR; 1; |
TIGRFAMs | TIGR00407; ProA; 1; |
PROSITE | PS01223; PROA; 1; |
Additional information
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Size range | 370-500 amino acids |
Related rules | None |
Fusion | None |