HAMAP rule MF_00425

General rule information [?]

Accession	MF_00425
Dates	13-JUL-2001 (Created) 1-JUN-2023 (Last updated, Version 26)
Name	NqrA
Scope(s)	Bacteria
Template(s)	Q56586 (NQRA_VIBAL); A5F5X1 (NQRA_VIBC3); [ Recover all ]
Triggered by	HAMAP; MF_00425 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NQRA
Protein name	RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A; Short=Na(+)-NQR subunit A; Short=Na(+)-translocating NQR subunit A; EC=7.2.1.1; AltName: Full=NQR complex subunit A; AltName: Full=NQR-1 subunit A;
Gene name	Name=nqrA;

Comments [?]

FUNCTION	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
CATALYTIC ACTIVITY	Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.2.1.1;
SUBUNIT	Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
SIMILARITY	Belongs to the NqrA family.

Keywords [?]

NAD
Ubiquinone
Transport
Ion transport
Sodium
Sodium transport
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>

Gene Ontology [?]

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

GO:0006814; Biological process:sodium ion transport

Cross-references [?]

Pfam	PF05896; NQRA; 1;
NCBIfam	TIGR01936; NqrA; 1;

Features [?]

Additional information [?]