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HAMAP rule MF_00425

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General rule information [?]

Accession MF_00425
Dates 13-JUL-2001 (Created)
1-JUN-2023 (Last updated, Version 26)
Name NqrA
Scope(s) Bacteria
Template(s) Q56586 (NQRA_VIBAL); A5F5X1 (NQRA_VIBC3); [ Recover all ]
Triggered by HAMAP; MF_00425 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NQRA
Protein name RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A;
                 Short=Na(+)-NQR subunit A;
                 Short=Na(+)-translocating NQR subunit A;
AltName: Full=NQR complex subunit A;
AltName: Full=NQR-1 subunit A;
Gene name Name=nqrA;

Comments [?]

FUNCTIONNQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
CATALYTIC ACTIVITY Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
SUBUNITComposed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
SIMILARITYBelongs to the NqrA family.

Keywords [?]

Ion transport
Sodium transport
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>

Gene Ontology [?]

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0006814; Biological process:sodium ion transport

Cross-references [?]

Pfam PF05896; NQRA; 1;
NCBIfam TIGR01936; NqrA; 1;

Features [?]

Additional information [?]

Size range 400-505 amino acids
Related rules None
Fusion Nter: None Cter: None

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