HAMAP rule MF_00425

General rule information [?]

Accession	MF_00425
Dates	13-JUL-2001 (Created) 11-JAN-2021 (Last updated, Version 25)

Name

NqrA

Scope

Bacteria

Templates

Q56586 (NQRA_VIBAL); A5F5X1 (NQRA_VIBC3): [Recover all]

Triggered by

HAMAP; MF_00425 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NQRA

Protein name

RecName:		Full=Na(+)-translocating NADH-quinone reductase subunit A;
		Short=Na(+)-NQR subunit A;
		Short=Na(+)-translocating NQR subunit A;
		EC 7.2.1.1;
AltName:		Full=NQR complex subunit A;
AltName:		Full=NQR-1 subunit A;

Gene name

nqrA

Comments [?]

Function	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Catalytic activity	RHEA:47748: a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+) EC 7.2.1.1
Subunit	Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
Similarity	Belongs to the NqrA family.

Keywords [?]

NAD
Ubiquinone
Transport
Ion transport
Sodium
Sodium transport
Translocase

Gene Ontology [?]

GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0006814; Biological process: sodium ion transport.

Cross-references [?]

Pfam	PF05896; NQRA; 1;
TIGRFAMs	TIGR01936; NqrA; 1;

Additional information [?]

Size range	400-505 amino acids
Related rules	None
Fusion	None

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