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HAMAP rule MF_00426

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General rule information [?]

Accession MF_00426
Dates 16-JUL-2001 (Created)
1-JUN-2023 (Last updated, Version 45)
Name NqrB
Scope(s) Bacteria
Template(s) Q56587 (NQRB_VIBAL); A5F5X0 (NQRB_VIBC3); [ Recover all ]
Triggered by HAMAP; MF_00426 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NQRB
Protein name RecName: Full=Na(+)-translocating NADH-quinone reductase subunit B;
                 Short=Na(+)-NQR subunit B;
                 Short=Na(+)-translocating NQR subunit B;
AltName: Full=NQR complex subunit B;
AltName: Full=NQR-1 subunit B;
Gene name Name=nqrB;

Comments [?]

FUNCTIONNQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
CATALYTIC ACTIVITY Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
SUBUNITComposed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the NqrB/RnfD family.

Keywords [?]

<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>
Ion transport
Sodium transport
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <FT:1>
end case
Transmembrane helix

Gene Ontology [?]

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0006814; Biological process:sodium ion transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03116; NQR2_RnfD_RnfE; 1;
PIRSF PIRSF016055; NADH-UbQ_OxRdtase_B_su; 1;
NCBIfam TIGR01937; NqrB; 1;
General Transmembrane; -; 8-10;

Features [?]

From: NQRB_VIBAL (Q56587)
Key From To Description Tag Condition FTGroup
MOD_RES 236 236 /note="FMN phosphoryl threonine" T

Additional information [?]

Size range 380-503 amino acids
Related rules MF_00462
Fusion Nter: None Cter: None

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