HAMAP rule MF_00426
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_00426 |
| Accession | MF_00426 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 38) |
| Name | NqrB |
| Scope(s) |
Bacteria |
| Template(s) | Q56587; A5F5X0; [ Recover all ] |
| Triggered by |
HAMAP; MF_00426 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | NQRB |
| Protein name | RecName: Full=Na(+)-translocating NADH-quinone reductase subunit B; Short=Na(+)-NQR subunit B; Short=Na(+)-translocating NQR subunit B; EC=7.2.1.1; AltName: Full=NQR complex subunit B; AltName: Full=NQR-1 subunit B; |
| Gene name | Name=nqrB; |
Comments
[?]
| FUNCTION | NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. |
| CATALYTIC ACTIVITY | Reaction=a ubiquinone + n Na(+)(in) + NADH + H(+) = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.2.1.1; |
| COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; |
| SUBUNIT | Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the NqrB/RnfD family. |
Keywords
[?]
| Translocase | |
| NAD | |
| Ubiquinone | |
| Transport | |
| Ion transport | |
| Sodium | |
| Sodium transport | |
| Flavoprotein | |
| FMN | |
| Cell membrane | |
| Membrane | |
| Transmembrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| case <FT:1> | |
| Phosphoprotein | |
| end case | |
| Transmembrane helix | |
Gene Ontology
[?]
| GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0006814; Biological process:sodium ion transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
[?]
| Pfam | PF03116; NQR2_RnfD_RnfE; 1; |
| PIRSF | PIRSF016055; NADH-UbQ_OxRdtase_B_su; 1; |
| NCBIfam | TIGR01937; NqrB; 1; |
| General | Transmembrane; -; 8-10; |
Features
[?]
| From: NQRB_VIBAL (Q56587) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 236 | 236 | /note="FMN phosphoryl threonine" | T | ||||||||
Additional information
[?]
| Size range | 380-503 amino acids |
| Related rules |
MF_00462 |
| Fusion | Nter: None Cter: None |