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Annotation rule MF_00428
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General rule information [?]

Accession MF_00428
Dates 16-JUL-2001 (Created)
18-NOV-2019 (Last updated, Version 39)
Name NqrD
Scope
Bacteria
Templates Q57095 (NQRD_VIBAL); A5F5Y6 (NQRD_VIBC3): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NQRD
Protein name
RecName: Full=Na(+)-translocating NADH-quinone reductase subunit D;
Short=Na(+)-NQR subunit D;
Short=Na(+)-translocating NQR subunit D;
EC 7.2.1.1;
AltName: Full=NQR complex subunit D;
AltName: Full=NQR-1 subunit D;
Gene name
nqrD

Comments [?]

Function NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Catalytic activity RHEA:47748: a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)
EC 7.2.1.1
Subunit Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the NqrDE/RnfAE family.

Keywords [?]

Translocase
NAD
Ubiquinone
Transport
Ion transport
Sodium
Sodium transport
Cell membrane
Membrane
Transmembrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0006814; Biological process: sodium ion transport.
GO:0055114; Biological process: oxidation-reduction process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02508; Rnf-Nqr; 1;
PIRSF PIRSF006102; NQR_DE; 1;
TIGRFAMs TIGR01939; NqrD; 1;

Computed features [?]

General Transmembrane; -; 5-7; trigger=yes;

Additional information [?]

Size range 195-254 amino acids
Related rules MF_00429 (NQRE)
Fusion None


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