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HAMAP rule MF_00428

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General rule information [?]

Accession MF_00428
Dates 16-JUL-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name NqrD
Scope(s) Bacteria
Template(s) Q57095 (NQRD_VIBAL); A5F5Y6 (NQRD_VIBC3); [ Recover all ]
Triggered by HAMAP; MF_00428 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NQRD
Protein name RecName: Full=Na(+)-translocating NADH-quinone reductase subunit D;
                 Short=Na(+)-NQR subunit D;
                 Short=Na(+)-translocating NQR subunit D;
AltName: Full=NQR complex subunit D;
AltName: Full=NQR-1 subunit D;
Gene name Name=nqrD;

Comments [?]

FUNCTIONNQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
CATALYTIC ACTIVITY Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
SUBUNITComposed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the NqrDE/RnfAE family.

Keywords [?]

<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>
Ion transport
Sodium transport
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0006814; Biological process:sodium ion transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02508; Rnf-Nqr; 1;
NCBIfam TIGR01939; NqrD; 1;
General Transmembrane; -; 5-7;

Features [?]

Additional information [?]

Size range 195-254 amino acids
Related rules MF_00429
Fusion Nter: None Cter: None

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