HAMAP rule MF_00442
General rule information
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Accession | MF_00442 |
Dates | 29-AUG-2001 (Created)
13-NOV-2023 (Last updated, Version 33) |
Name | Helicase_Hel308 |
Scope(s) |
Archaea |
Template(s) | O73946 (HELS_PYRFU); O26901 (HELS_METTH); Q974S1 (HELS_SULTO); D0KN27 (HELS_SACS9); [ Recover all ] |
Triggered by |
HAMAP; MF_00442 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | HELS |
RecName: Full=ATP-dependent DNA helicase Hel308;<br /> EC=<a href="https://enzyme.expasy.org/EC/5.6.2.4">5.6.2.4</a>;<br /> AltName: Full=DNA 3'-5' helicase Hel308; | |
Gene name | Name=hel308; |
Comments
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FUNCTION | DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. |
CATALYTIC ACTIVITY | Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.; EC=5.6.2.4; |
CATALYTIC ACTIVITY | Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4; |
SUBUNIT | Monomer. |
SIMILARITY | Belongs to the helicase family. Hel308 subfamily. |
Keywords
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ATP-binding | |
DNA-binding | |
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a> | |
Hydrolase | |
Isomerase | |
Nucleotide-binding | |
DNA damage | |
DNA repair |
Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0003677; Molecular function:DNA binding |
GO:0043138; Molecular function:3'-5' DNA helicase activity |
GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
GO:0006281; Biological process:DNA repair |
Cross-references
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Pfam | PF00270; DEAD; 1; |
Pfam | PF00271; Helicase_C; 1; |
Pfam | PF00633; HHH; 1; |
PROSITE | PS51192; HELICASE_ATP_BIND_1; 1; |
PROSITE | PS51194; HELICASE_CTER; 1; |
Features
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From: HELS_PYRFU (O73946) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 28 | 28 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
Q |
Additional information
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Size range | 639-880 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Intein in some members. |