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HAMAP rule MF_00442

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General rule information [?]

Accession MF_00442
Dates 29-AUG-2001 (Created)
13-NOV-2023 (Last updated, Version 33)
Name Helicase_Hel308
Scope(s) Archaea
Template(s) O73946 (HELS_PYRFU); O26901 (HELS_METTH); Q974S1 (HELS_SULTO); D0KN27 (HELS_SACS9); [ Recover all ]
Triggered by HAMAP; MF_00442 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HELS
RecName: Full=ATP-dependent DNA helicase Hel308;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/5.6.2.4">5.6.2.4</a>;<br /> AltName: Full=DNA 3'-5' helicase Hel308;
Gene name Name=hel308;

Comments [?]

FUNCTIONDNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
CATALYTIC ACTIVITY Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.; EC=5.6.2.4;
CATALYTIC ACTIVITY Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
SUBUNITMonomer.
SIMILARITYBelongs to the helicase family. Hel308 subfamily.

Keywords [?]

ATP-binding
DNA-binding
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Isomerase
Nucleotide-binding
DNA damage
DNA repair

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0043138; Molecular function:3'-5' DNA helicase activity
GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0006281; Biological process:DNA repair

Cross-references [?]

Pfam PF00270; DEAD; 1;
Pfam PF00271; Helicase_C; 1;
Pfam PF00633; HHH; 1;
PROSITE PS51192; HELICASE_ATP_BIND_1; 1;
PROSITE PS51194; HELICASE_CTER; 1;

Features [?]

From: HELS_PYRFU (O73946)
Key From To Description Tag Condition FTGroup
BINDING 28 28 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
Q

Additional information [?]

Size range 639-880 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Intein in some members.



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