HAMAP rule MF_00446
General rule information
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| Accession | MF_00446 |
| Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 41) |
| Name | PanD |
| Scope | Bacteria
Archaea |
| Templates | P0A790 (PAND_ECOLI); P56065 (PAND_HELPY): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. |
| Catalytic activity | RHEA:19497: H(+) + L-aspartate = beta-alanine + CO2
EC 4.1.1.11 |
| Cofactor | pyruvate Note: Binds 1 pyruvoyl group covalently per subunit. |
| Pathway | Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1. |
| Subunit | Heterooctamer of four alpha and four beta subunits. |
| Subcellular location | Cytoplasm. |
| Ptm | Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. |
| Similarity | Belongs to the PanD family. |
Keywords
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Autocatalytic cleavage
Cytoplasm
Decarboxylase
Lyase
Pantothenate biosynthesis
Pyruvate
Schiff base
Zymogen
Cytoplasm
Decarboxylase
Lyase
Pantothenate biosynthesis
Pyruvate
Schiff base
Zymogen
Gene Ontology
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GO:0004068; Molecular function: aspartate 1-decarboxylase activity.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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| From: PAND_ECOLI (P0A790) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| CHAIN | Nter | 24 | Aspartate 1-decarboxylase beta chain | |||||||||
| CHAIN | 25 | Cter | Aspartate 1-decarboxylase alpha chain | |||||||||
| BINDING | 73 | 75 | /ligand="substrate | G-[AGPS]-[AT] | ||||||||
| ACT_SITE | 25 | 25 | Schiff-base intermediate with substrate; via pyruvic acid | S | ||||||||
| ACT_SITE | 58 | 58 | Proton donor | Y | ||||||||
| BINDING | 57 | 57 | /ligand="substrate | T | ||||||||
| MOD_RES | 25 | 25 | Pyruvic acid (Ser) | S | ||||||||
Additional information
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| Size range | 111-180 amino acids |
| Related rules | None |
| Fusion | None |