HAMAP rule MF_00446
General rule information
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| Accession | MF_00446 |
| Dates | 1-JUN-2001 (Created)
3-SEP-2024 (Last updated, Version 42) |
| Name | PanD |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A790 (PAND_ECOLI); P56065 (PAND_HELPY); [ Recover all ] |
| Triggered by |
HAMAP; MF_00446 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PAND |
| Protein name | RecName: Full=Aspartate 1-decarboxylase; EC=4.1.1.11; AltName: Full=Aspartate alpha-decarboxylase; Contains: RecName: Full=Aspartate 1-decarboxylase beta chain; Contains: RecName: Full=Aspartate 1-decarboxylase alpha chain; Flags: Precursor; |
| Gene name | Name=panD; |
Comments
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| FUNCTION | Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. |
| CATALYTIC ACTIVITY | Reaction=L-aspartate + H(+) = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=4.1.1.11; |
| COFACTOR | Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.; |
| PATHWAY | Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta- alanine from L-aspartate: step 1/1. |
| SUBUNIT | Heterooctamer of four alpha and four beta subunits. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| PTM | Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta- subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. |
| SIMILARITY | Belongs to the PanD family. |
Keywords
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| Autocatalytic cleavage |
| Cytoplasm |
| Decarboxylase |
| Lyase |
| Pantothenate biosynthesis |
| Pyruvate |
| Schiff base |
| Zymogen |
Gene Ontology
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| GO:0004068; Molecular function:aspartate 1-decarboxylase activity |
| GO:0015940; Biological process:pantothenate biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: PAND_ECOLI (P0A790) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| CHAIN | Nter | 24 | /note="Aspartate 1-decarboxylase beta chain" | |||||||||
| CHAIN | 25 | Cter | /note="Aspartate 1-decarboxylase alpha chain" | |||||||||
| BINDING | 73 | 75 | /ligand="substrate" | G-[AGPS]-[AT] | ||||||||
| ACT_SITE | 25 | 25 | /note="Schiff-base intermediate with substrate; via pyruvic acid" | S | ||||||||
| ACT_SITE | 58 | 58 | /note="Proton donor" | Y | ||||||||
| BINDING | 57 | 57 | /ligand="substrate" | T | ||||||||
| MOD_RES | 25 | 25 | /note="Pyruvic acid (Ser)" | S | ||||||||
Additional information
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| Size range | 111-180 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |