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HAMAP rule MF_00446

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General rule information [?]

Accession MF_00446
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name PanD
Scope(s) Bacteria
Template(s) P0A790 (PAND_ECOLI); P56065 (PAND_HELPY); [ Recover all ]
Triggered by HAMAP; MF_00446 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PAND
Protein name RecName: Full=Aspartate 1-decarboxylase;
AltName: Full=Aspartate alpha-decarboxylase;
RecName: Full=Aspartate 1-decarboxylase beta chain;
RecName: Full=Aspartate 1-decarboxylase alpha chain;
                 Flags: Precursor;
Gene name Name=panD;

Comments [?]

FUNCTIONCatalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
CATALYTIC ACTIVITY Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=;
COFACTOR Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.;
PATHWAYCofactor biosynthesis; (R)-pantothenate biosynthesis; beta- alanine from L-aspartate: step 1/1.
SUBUNITHeterooctamer of four alpha and four beta subunits.
PTMIs synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta- subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.
SIMILARITYBelongs to the PanD family.

Keywords [?]

Gene Ontology [?]

GO:0004068; Molecular function:aspartate 1-decarboxylase activity
GO:0015940; Biological process:pantothenate biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02261; Asp_decarbox; 1;
NCBIfam TIGR00223; PanD; 1;

Features [?]

From: PAND_ECOLI (P0A790)
Key From To Description Tag Condition FTGroup
CHAIN Nter 24 /note="Aspartate 1-decarboxylase beta chain"
CHAIN 25 Cter /note="Aspartate 1-decarboxylase alpha chain"
BINDING 73 75 /ligand="substrate" G-[AGPS]-[AT]
ACT_SITE 25 25 /note="Schiff-base intermediate with substrate; via pyruvic acid" S
ACT_SITE 58 58 /note="Proton donor" Y
BINDING 57 57 /ligand="substrate" T
MOD_RES 25 25 /note="Pyruvic acid (Ser)" S

Additional information [?]

Size range 111-180 amino acids
Related rules None
Fusion Nter: None Cter: None

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