HAMAP rule MF_00446
General rule information
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Accession | MF_00446 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41) |
Name | PanD |
Scope(s) |
Bacteria Archaea |
Template(s) | P0A790 (PAND_ECOLI); P56065 (PAND_HELPY); [ Recover all ] |
Triggered by |
HAMAP; MF_00446 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PAND |
Protein name | RecName: Full=Aspartate 1-decarboxylase; EC=4.1.1.11; AltName: Full=Aspartate alpha-decarboxylase; Contains: RecName: Full=Aspartate 1-decarboxylase beta chain; Contains: RecName: Full=Aspartate 1-decarboxylase alpha chain; Flags: Precursor; |
Gene name | Name=panD; |
Comments
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FUNCTION | Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. |
CATALYTIC ACTIVITY | Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=4.1.1.11; |
COFACTOR | Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.; |
PATHWAY | Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta- alanine from L-aspartate: step 1/1. |
SUBUNIT | Heterooctamer of four alpha and four beta subunits. |
SUBCELLULAR LOCATION | Cytoplasm. |
PTM | Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta- subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. |
SIMILARITY | Belongs to the PanD family. |
Keywords
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Autocatalytic cleavage |
Cytoplasm |
Decarboxylase |
Lyase |
Pantothenate biosynthesis |
Pyruvate |
Schiff base |
Zymogen |
Gene Ontology
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GO:0004068; Molecular function:aspartate 1-decarboxylase activity |
GO:0015940; Biological process:pantothenate biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: PAND_ECOLI (P0A790) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
CHAIN | Nter | 24 | /note="Aspartate 1-decarboxylase beta chain" | |||||||||
CHAIN | 25 | Cter | /note="Aspartate 1-decarboxylase alpha chain" | |||||||||
BINDING | 73 | 75 | /ligand="substrate" | G-[AGPS]-[AT] | ||||||||
ACT_SITE | 25 | 25 | /note="Schiff-base intermediate with substrate; via pyruvic acid" | S | ||||||||
ACT_SITE | 58 | 58 | /note="Proton donor" | Y | ||||||||
BINDING | 57 | 57 | /ligand="substrate" | T | ||||||||
MOD_RES | 25 | 25 | /note="Pyruvic acid (Ser)" | S |
Additional information
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Size range | 111-180 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |