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HAMAP rule MF_00446

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General rule information [?]

Accession MF_00446
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name PanD
Templates P0A790 (PAND_ECOLI); P56065 (PAND_HELPY): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Aspartate 1-decarboxylase;
AltName: Full=Aspartate alpha-decarboxylase;
RecName: Full=Aspartate 1-decarboxylase beta chain;
RecName: Full=Aspartate 1-decarboxylase alpha chain;
Flags: Precursor;
Gene name

Comments [?]

Function Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Catalytic activity RHEA:19497: H(+) + L-aspartate = beta-alanine + CO2
Cofactor pyruvate
Note: Binds 1 pyruvoyl group covalently per subunit.
Pathway Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.
Subunit Heterooctamer of four alpha and four beta subunits.
Subcellular location Cytoplasm.
Ptm Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.
Similarity Belongs to the PanD family.

Keywords [?]

Gene Ontology [?]

GO:0004068; Molecular function: aspartate 1-decarboxylase activity.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02261; Asp_decarbox; 1;
NCBIfam TIGR00223; PanD; 1;

Features [?]

From: PAND_ECOLI (P0A790)
Key     From     To       Description   Tag   Condition   FTGroup
CHAIN     Nter     24       Aspartate 1-decarboxylase beta chain        
CHAIN     25     Cter       Aspartate 1-decarboxylase alpha chain        
BINDING     73     75       /ligand="substrate     G-[AGPS]-[AT]  
ACT_SITE     25     25       Schiff-base intermediate with substrate; via pyruvic acid     S  
ACT_SITE     58     58       Proton donor     Y  
BINDING     57     57       /ligand="substrate     T  
MOD_RES     25     25       Pyruvic acid (Ser)     S  

Additional information [?]

Size range 111-180 amino acids
Related rules None
Fusion None