HAMAP rule MF_00470
General rule information
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| Accession | MF_00470 |
| Dates | 24-OCT-2001 (Created)
1-JUN-2023 (Last updated, Version 34) |
| Name | MenC_1 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P29208 (MENC_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00470 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MENC |
| Protein name | RecName: Full=o-succinylbenzoate synthase; Short=OSB synthase; Short=OSBS; EC=4.2.1.113; AltName: Full=4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; AltName: Full=o-succinylbenzoic acid synthase; |
| Gene name | Name=menC; |
Comments
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| FUNCTION | Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). |
| CATALYTIC ACTIVITY | Reaction=(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O; Xref=Rhea:RHEA:10196, ChEBI:CHEBI:15377, ChEBI:CHEBI:18325, ChEBI:CHEBI:58689; EC=4.2.1.113; |
| COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; |
| PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7. |
| case not <OC:Cyanobacteriota> | |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| else case <OC:Cyanobacteriota> | |
| PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
| end case | |
| SIMILARITY | Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily. |
Keywords
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| case not <OC:Cyanobacteriota> | |
| Menaquinone biosynthesis | |
| end case | |
| Lyase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0016836; Molecular function:hydro-lyase activity | |
| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| case not <OCellular component:Cyanobacteriota> | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0042372; Biological process:phylloquinone biosynthetic process | |
| end case | |
Cross-references
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Features
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| From: MENC_ECOLI (P29208) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 133 | 133 | /note="Proton donor" | K | ||||||||
| ACT_SITE | 235 | 235 | /note="Proton acceptor" | K | ||||||||
| BINDING | 161 | 161 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
| BINDING | 190 | 190 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| BINDING | 213 | 213 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
Additional information
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| Size range | 304-400 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |