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HAMAP rule MF_00470

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General rule information [?]

Accession MF_00470
Dates 24-OCT-2001 (Created)
1-JUN-2023 (Last updated, Version 34)
Name MenC_1
Scope(s) Bacteria
Template(s) P29208 (MENC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00470 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MENC
Protein name RecName: Full=o-succinylbenzoate synthase;
                 Short=OSB synthase;
AltName: Full=4-(2'-carboxyphenyl)-4-oxybutyric acid synthase;
AltName: Full=o-succinylbenzoic acid synthase;
Gene name Name=menC;

Comments [?]

FUNCTIONConverts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
CATALYTIC ACTIVITY Reaction=(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O; Xref=Rhea:RHEA:10196, ChEBI:CHEBI:15377, ChEBI:CHEBI:18325, ChEBI:CHEBI:58689; EC=;
COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
PATHWAYQuinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.
case not <OC:Cyanobacteriota>
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteriota>
PATHWAYCofactor biosynthesis; phylloquinone biosynthesis.
end case
SIMILARITYBelongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.

Keywords [?]

case not <OC:Cyanobacteriota>
Menaquinone biosynthesis
end case
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0016836; Molecular function:hydro-lyase activity
case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
case not <OCellular component:Cyanobacteriota>
GO:0009234; Biological process:menaquinone biosynthetic process
else case <OCellular component:Cyanobacteriota>
GO:0042372; Biological process:phylloquinone biosynthetic process
end case

Cross-references [?]

Pfam PF01188; MR_MLE; 1;
NCBIfam TIGR01927; menC_gamma/gm+; 1;

Features [?]

From: MENC_ECOLI (P29208)
Key From To Description Tag Condition FTGroup
ACT_SITE 133 133 /note="Proton donor" K
ACT_SITE 235 235 /note="Proton acceptor" K
BINDING 161 161 /ligand="Mg(2+)"
D 1
BINDING 190 190 /ligand="Mg(2+)"
E 1
BINDING 213 213 /ligand="Mg(2+)"
D 1

Additional information [?]

Size range 304-400 amino acids
Related rules None
Fusion Nter: None Cter: None

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