HAMAP rule MF_00471
General rule information
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| Accession | MF_00471 |
| Dates | 24-OCT-2001 (Created) 1-JUN-2023 (Last updated, Version 30) |
| Name | RraA |
| Scope | Bacteria; Gammaproteobacteria |
| Template | P0A8R0 (RRAA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. |
| Subunit | Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the RraA family. |
Keywords
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Gene Ontology
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GO:0060698; Molecular function: endoribonuclease inhibitor activity.
GO:0019899; Molecular function: enzyme binding.
GO:0060699; Biological process: regulation of endoribonuclease activity.
GO:0005737; Cellular component: cytoplasm.
GO:0019899; Molecular function: enzyme binding.
GO:0060699; Biological process: regulation of endoribonuclease activity.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Additional information
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| Size range | 157-173 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Although it was initially thought to be a methyltransferase involved in the last step of the menaquinone pathway, it is not clustered with other enzymes of the menaquinone pathway in most bacteria, and does not have such enzymatic activity. Difficult to separate RRAA and RRAAH entries, but it seems that RRAA entries have [DN]-A-E at E.coli positions 75-77. RRAAH have G-[GD]. See PubMed:24359411 |