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HAMAP rule MF_00471

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General rule information [?]

Accession MF_00471
Dates 24-OCT-2001 (Created)
1-JUN-2023 (Last updated, Version 30)
Name RraA
Scope(s) Bacteria
Template(s) P0A8R0 (RRAA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00471 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RRAA
Protein name RecName: Full=Regulator of ribonuclease activity A;
Gene name Name=rraA;

Comments [?]

FUNCTIONGlobally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
SUBUNITHomotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.
SIMILARITYBelongs to the RraA family.

Keywords [?]

Gene Ontology [?]

GO:0060698; Molecular function:endoribonuclease inhibitor activity
GO:0019899; Molecular function:enzyme binding
GO:0060699; Biological process:regulation of endoribonuclease activity
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03737; Methyltransf_6; 1;
NCBIfam TIGR01935; NOT-MenG; 1;
NCBIfam TIGR02998; RraA_entero; 1;

Features [?]

Additional information [?]

Size range 157-173 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Although it was initially thought to be a methyltransferase involved in the last step of the menaquinone pathway, it is not clustered with other enzymes of the menaquinone pathway in most bacteria, and does not have such enzymatic activity. Difficult to separate RRAA and RRAAH entries, but it seems that RRAA entries have [DN]-A-E at E.coli positions 75-77. RRAAH have G-[GD]. See PubMed:24359411

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