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HAMAP rule MF_00471

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General rule information [?]

Accession MF_00471
Dates 24-OCT-2001 (Created)
1-JUN-2023 (Last updated, Version 30)
Name RraA
Bacteria; Gammaproteobacteria
Template P0A8R0 (RRAA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Regulator of ribonuclease activity A;
Gene name

Comments [?]

Function Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
Subunit Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.
Subcellular location Cytoplasm.
Similarity Belongs to the RraA family.

Keywords [?]

Gene Ontology [?]

GO:0060698; Molecular function: endoribonuclease inhibitor activity.
GO:0019899; Molecular function: enzyme binding.
GO:0060699; Biological process: regulation of endoribonuclease activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03737; Methyltransf_6; 1;
NCBIfam TIGR01935; NOT-MenG; 1;
TIGR02998; RraA_entero; 1;

Additional information [?]

Size range 157-173 amino acids
Related rules None
Fusion None
Comments Although it was initially thought to be a methyltransferase involved in the last step of the menaquinone pathway, it is not clustered with other enzymes of the menaquinone pathway in most bacteria, and does not have such enzymatic activity. Difficult to separate RRAA and RRAAH entries, but it seems that RRAA entries have [DN]-A-E at E.coli positions 75-77. RRAAH have G-[GD]. See PubMed:24359411