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HAMAP rule MF_00472

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General rule information [?]

Accession MF_00472
Dates 24-OCT-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name UbiG
Scope(s) Bacteria
Template(s) P17993 (UBIG_ECOLI); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00472 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UBIG
case <OC:Escherichia>
Protein name RecName: Full=Ubiquinone biosynthesis O-methyltransferase;
AltName: Full=3-demethylubiquinone-8 3-O-methyltransferase;
AltName: Full=2-octaprenyl-6-hydroxyphenol methylase;
Protein name RecName: Full=Ubiquinone biosynthesis O-methyltransferase;
AltName: Full=3-demethylubiquinone 3-O-methyltransferase;
AltName: Full=2-polyprenyl-6-hydroxyphenol methylase;
end case
Gene name Name=ubiG;

Comments [?]

FUNCTIONO-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
CATALYTIC ACTIVITY Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44380, Rhea:RHEA- COMP:9566, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:15378, ChEBI:CHEBI:17976, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84422; EC=;
CATALYTIC ACTIVITY Reaction=a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L- methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:31411, Rhea:RHEA-COMP:9550, Rhea:RHEA-COMP:9551, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:62729, ChEBI:CHEBI:62731; EC=;
PATHWAYCofactor biosynthesis; ubiquinone biosynthesis.
SIMILARITYBelongs to the methyltransferase superfamily. UbiG/COQ3 family.

Keywords [?]

Gene Ontology [?]

GO:0061542; Molecular function:3-demethylubiquinol-n 3-O-methyltransferase activity
GO:0006744; Biological process:ubiquinone biosynthetic process

Cross-references [?]

NCBIfam TIGR01983; UbiG; 1;

Features [?]

From: UBIG_ECOLI (P17993)
Key From To Description Tag Condition FTGroup
BINDING 44 44 /ligand="S-adenosyl-L-methionine"
BINDING 64 64 /ligand="S-adenosyl-L-methionine"
BINDING 85 85 /ligand="S-adenosyl-L-methionine"
BINDING 129 129 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 232-261 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-8 in E.coli, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.

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